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Insulin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Insulin-like [ 56993]
Superfamily:   Insulin-like [ 56994]
Families:   Insulin-like [ 56995] (4)


Superfamily statistics
Genomes (142) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 975 3,325 48
Proteins 966 3,310 48


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)cardiovascular system disease0Least InformativeDirect
Disease Ontology (DO)nervous system disease0.3812Least InformativeInherited
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)artery disease0Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.0003828Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.0004476Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.007033Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.01775Moderately InformativeInherited
Disease Ontology (DO)syndrome0.01812Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.1154Moderately InformativeInherited
Disease Ontology (DO)hypertension0InformativeDirect
Disease Ontology (DO)carcinoma0InformativeDirect
Disease Ontology (DO)overnutrition0.00003617InformativeDirect
Disease Ontology (DO)motor neuron disease0.0001136InformativeDirect
Disease Ontology (DO)interstitial lung disease0.0001189InformativeDirect
Disease Ontology (DO)endocrine gland cancer0.001824InformativeInherited
Disease Ontology (DO)liver disease0.005824InformativeInherited
Disease Ontology (DO)pancreas disease0.1591InformativeInherited
Disease Ontology (DO)hyperandrogenism0.00000008695Highly InformativeDirect
Disease Ontology (DO)endocrine pancreas disease0.00000371Highly InformativeDirect
Disease Ontology (DO)in situ carcinoma0.00008974Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.09728Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1529Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2419Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.03472Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.03695Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.1555Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal glucose homeostasis0.002868InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.04636InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.04038Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.13Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.00005628Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal glucose homeostasis0.02404InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.05065InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.1193InformativeInherited
Mammalian Phenotype (MP)decreased birth weight0.000002496Highly InformativeDirect
Mammalian Phenotype (MP)decreased fetal size0.0007782Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.00121Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.00000002376Least InformativeDirect
Worm Phenotype (WP)cell development variant0.2169Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0000000006124Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.0006979Moderately InformativeDirect
Worm Phenotype (WP)body length variant0.0000000006577InformativeDirect
Worm Phenotype (WP)body width variant0.000000001625InformativeDirect
Worm Phenotype (WP)body posture variant0.000000514InformativeDirect
Worm Phenotype (WP)localized movement variant0.000007203InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.00008075InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.0001755InformativeDirect
Worm Phenotype (WP)foraging behavior variant0.0002015InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.003237InformativeInherited
Worm Phenotype (WP)locomotion reduced0.8396InformativeInherited
Worm Phenotype (WP)dauer development variant0Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0.000000000002352Highly InformativeDirect
Worm Phenotype (WP)forward point velocity variant0.00000000001212Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.0000000000163Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0.000004347Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.0006077Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)mating defective0.0002402Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Insulin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the Insulin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]