SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Insulin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Insulin-like [ 56993]
Superfamily:   Insulin-like [ 56994]
Families:   Insulin-like [ 56995] (4)


Superfamily statistics
Genomes (142) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 975 2,885 48
Proteins 966 2,872 48


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.000000000024830Least InformativeDirect
Biological Process (BP)biological regulation0.00000046460.000000000009485Least InformativeDirect
Biological Process (BP)response to endogenous stimulus0.0000000017250Moderately InformativeDirect
Biological Process (BP)response to organic substance00.00000000000003429Moderately InformativeDirect
Biological Process (BP)regulation of cell communication0.000036930.0000000001442Moderately InformativeDirect
Biological Process (BP)regulation of signaling0.000018520.0000000001589Moderately InformativeDirect
Biological Process (BP)regulation of localization0.000070940.000000000000007296Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.00000017160.0000000007475Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.026450.01987Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.071080.0002272Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.025350.04056Moderately InformativeInherited
Biological Process (BP)regulation of molecular function0.10930.2494Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.51250.00002997Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.0030570.000002108Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.069710.441Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.15350.02419Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.0013210.0000000004204Moderately InformativeInherited
Biological Process (BP)single-organism transport0.0072650.4727Moderately InformativeInherited
Biological Process (BP)organic substance transport0.0021850.4301Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.8941Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.31840.08387Moderately InformativeInherited
Biological Process (BP)cell communication0.0098060.000003118Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.64611Moderately InformativeInherited
Biological Process (BP)single organism signaling0.056780.0003931Moderately InformativeInherited
Biological Process (BP)cell surface receptor signaling pathway0.000024440.0000001805InformativeDirect
Biological Process (BP)behavior0.0000079540.0002188InformativeDirect
Biological Process (BP)response to extracellular stimulus0.000007390.000000000007901InformativeDirect
Biological Process (BP)regulation of hormone levels0.000015750.0000000000004774InformativeDirect
Biological Process (BP)regulation of apoptotic process0.0000000099650InformativeDirect
Biological Process (BP)positive regulation of catalytic activity0.0000072180.0003347InformativeDirect
Biological Process (BP)positive regulation of transport0.00023930InformativeDirect
Biological Process (BP)negative regulation of transport0.00022360.0000000000007685InformativeDirect
Biological Process (BP)response to nitrogen compound0.0000000000012430InformativeDirect
Biological Process (BP)response to acid chemical0.02930.0775InformativeInherited
Biological Process (BP)regulation of peptide transport0.026020.02877InformativeInherited
Biological Process (BP)regulation of protein localization0.017480.004832InformativeInherited
Biological Process (BP)regulation of phosphorylation0.51590.956InformativeInherited
Biological Process (BP)positive regulation of cellular protein metabolic process0.281InformativeInherited
Biological Process (BP)positive regulation of phosphate metabolic process0.000070980.02081InformativeInherited
Biological Process (BP)regulation of protein modification process0.0027130.00003226InformativeInherited
Biological Process (BP)regulation of secretion0.11660.05031InformativeInherited
Biological Process (BP)negative regulation of cell death0.0015080.000000000005542InformativeInherited
Biological Process (BP)regulation of transmembrane transport0.18550.4737InformativeInherited
Biological Process (BP)response to temperature stimulus0.000000078950.004223InformativeInherited
Biological Process (BP)cellular response to hormone stimulus0.11460.08845InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.11290.1681InformativeInherited
Biological Process (BP)enzyme linked receptor protein signaling pathway0.0000000050210Highly InformativeDirect
Biological Process (BP)cell proliferation0.0000023980.0000000002522Highly InformativeDirect
Biological Process (BP)response to heat0.00034490.00000284Highly InformativeDirect
Biological Process (BP)regulation of cellular carbohydrate metabolic process0.0000091180Highly InformativeDirect
Biological Process (BP)regulation of transmembrane transporter activity0.0000022730.00000000371Highly InformativeDirect
Biological Process (BP)response to nutrient levels0.0000026440.0000000000009447Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic process0.00000000021960.00000002229Highly InformativeDirect
Biological Process (BP)response to amino acid0.00024950.00000327Highly InformativeDirect
Biological Process (BP)regulation of carbohydrate biosynthetic process0.000057190Highly InformativeDirect
Biological Process (BP)response to peptide hormone0.0000029480.0000005935Highly InformativeDirect
Biological Process (BP)regulation of hormone secretion0.0000092820.000000000005482Highly InformativeDirect
Biological Process (BP)positive regulation of secretion by cell0.00077380.000000000000007296Highly InformativeDirect
Biological Process (BP)positive regulation of peptide secretion0.033920.0000004517Highly InformativeInherited
Biological Process (BP)cellular response to organonitrogen compound0.031640.007336Highly InformativeInherited
Molecular Function (MF)binding0.000093190.00000002925Least InformativeDirect
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)macromolecular complex binding0.0000000059510.000000003035InformativeDirect
Cellular Component (CC)intracellular organelle part0.68651Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.28560.9682Least InformativeInherited
Cellular Component (CC)vesicle0.00013560.0000008834Moderately InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)intracellular organelle lumen0.11311Moderately InformativeInherited
Cellular Component (CC)endomembrane system0.0031780.0005522Moderately InformativeInherited
Cellular Component (CC)extracellular space00InformativeDirect
Cellular Component (CC)secretory granule0.000033370.0001996InformativeDirect
Cellular Component (CC)cytoplasmic vesicle part0.00085420.01727InformativeInherited
Cellular Component (CC)cytoplasmic vesicle lumen0.0000061370.000001827Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00003949 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0.000000000009485 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.8535 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) reproduction 0.000009043 Moderately Informative Direct
Biological Process (BP) cell communication 0.000003118 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.000002108 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00000000000003429 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.0000000001442 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.0000000001589 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.0004453 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000000000000007296 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.0003931 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0002272 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0000000004204 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000094 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00002997 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.0000000007475 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.01987 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.04056 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.104 Moderately Informative Inherited
Biological Process (BP) tissue development 0.8623 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.2369 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.218 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.441 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.02419 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.9861 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.2494 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.08387 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.4727 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.4301 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.3662 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.1648 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.02745 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.0000001805 Informative Direct
Biological Process (BP) behavior 0.0002188 Informative Direct
Biological Process (BP) embryo development 0.0003877 Informative Direct
Biological Process (BP) regulation of catabolic process 0.000000002894 Informative Direct
Biological Process (BP) response to extracellular stimulus 0.000000000007901 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0000000000005978 Informative Direct
Biological Process (BP) regulation of hormone levels 0.0000000000004774 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000000000001059 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.00000125 Informative Direct
Biological Process (BP) regulation of protein modification process 0.00003226 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0000001555 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0001745 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.0003347 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0007024 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0004577 Informative Direct
Biological Process (BP) positive regulation of transport 0 Informative Direct
Biological Process (BP) negative regulation of transport 0.0000000000007685 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.000005456 Informative Direct
Biological Process (BP) negative regulation of cell death 0.000000000005542 Informative Direct
Biological Process (BP) reproductive system development 0.0002356 Informative Direct
Biological Process (BP) response to nitrogen compound 0 Informative Direct
Biological Process (BP) regulation of protein localization 0.004832 Informative Inherited
Biological Process (BP) response to acid chemical 0.0775 Informative Inherited
Biological Process (BP) regulation of ion transport 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.02213 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.4737 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.02081 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.1475 Informative Inherited
Biological Process (BP) single organism reproductive process 0.005416 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.4236 Informative Inherited
Biological Process (BP) regulation of secretion 0.05031 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.956 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.9158 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.1603 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.4655 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.03132 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.1086 Informative Inherited
Biological Process (BP) response to temperature stimulus 0.004223 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.08845 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1681 Informative Inherited
Biological Process (BP) generation of neurons 0.678 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.02877 Informative Inherited
Biological Process (BP) post-embryonic development 0.2765 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.01524 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.009612 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.5422 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.03268 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.4454 Informative Inherited
Biological Process (BP) negative regulation of peptide secretion 0.000009898 Highly Informative Direct
Biological Process (BP) positive regulation of peptide secretion 0.0000004517 Highly Informative Direct
Biological Process (BP) response to osmotic stress 0.00001632 Highly Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0000000002522 Highly Informative Direct
Biological Process (BP) glycoprotein metabolic process 0.0001094 Highly Informative Direct
Biological Process (BP) response to heat 0.00000284 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of mitochondrion organization 0.0000000000001694 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.00000000371 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0.0000000000009447 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0.0005229 Highly Informative Direct
Biological Process (BP) negative regulation of ion transmembrane transport 0.00000000004101 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.000000002827 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.00000002229 Highly Informative Direct
Biological Process (BP) response to amino acid 0.00000327 Highly Informative Direct
Biological Process (BP) regulation of carbohydrate biosynthetic process 0 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.0000005935 Highly Informative Direct
Biological Process (BP) regulation of generation of precursor metabolites and energy 0 Highly Informative Direct
Biological Process (BP) positive regulation of nucleotide metabolic process 0.00002398 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.000000000005482 Highly Informative Direct
Biological Process (BP) embryonic organ development 0.000000002547 Highly Informative Direct
Biological Process (BP) anatomical structure maturation 0.00006161 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.00000000003456 Highly Informative Direct
Biological Process (BP) positive regulation of secretion by cell 0.000000000000007296 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.0000004943 Highly Informative Direct
Biological Process (BP) negative regulation of establishment of protein localization 0.000000000179 Highly Informative Direct
Biological Process (BP) regulation of apoptotic signaling pathway 0.00000000000001079 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.1577 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.1309 Highly Informative Inherited
Biological Process (BP) regulation of chromosome organization 0.7264 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.2594 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.002688 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.6193 Highly Informative Inherited
Biological Process (BP) germ cell development 0.0313 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 0.007336 Highly Informative Inherited
Biological Process (BP) cell maturation 0.001409 Highly Informative Inherited
Biological Process (BP) negative regulation of RNA metabolic process 0.007578 Highly Informative Inherited
Molecular Function (MF) binding 0.00000002925 Least Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.000000003035 Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.08801 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.9682 Least Informative Inherited
Cellular Component (CC) endomembrane system 0.0005522 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0000008834 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.00000006684 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.271 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) secretory granule 0.0001996 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0.00000000000001728 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.01727 Informative Inherited
Cellular Component (CC) cytoplasmic vesicle lumen 0.000001827 Highly Informative Direct
Cellular Component (CC) exocytic vesicle 0.00009064 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processOsteogenesis0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationToxin0.00000000000006824InformativeDirect
Post-translational modificationGrowth factor0Highly InformativeDirect
Post-translational modificationHormone0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect
Post-translational modificationHydroxylation0.0000000002781InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0Highly InformativeDirect
Post-translational modificationAmidation0.00000000003395Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Insulin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the Insulin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]