SUPERFAMILY 1.75 HMM library and genome assignments server

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Insulin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Insulin-like [ 56993]
Superfamily:   Insulin-like [ 56994]
Families:   Insulin-like [ 56995] (4)

Superfamily statistics
Genomes (142) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 975 0 48
Proteins 966 0 48

Functional annotation
General category Regulation
Detailed category Signal transduction

Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)nervous system disease0.3811Least InformativeInherited
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)artery disease0Moderately InformativeDirect
Disease Ontology (DO)endocrine system disease0.0003794Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.0004425Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.006994Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.01764Moderately InformativeInherited
Disease Ontology (DO)syndrome0.01804Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.1153Moderately InformativeInherited
Disease Ontology (DO)hypertension0InformativeDirect
Disease Ontology (DO)carcinoma0InformativeDirect
Disease Ontology (DO)overnutrition0.00003568InformativeDirect
Disease Ontology (DO)motor neuron disease0.0001125InformativeDirect
Disease Ontology (DO)interstitial lung disease0.0001176InformativeDirect
Disease Ontology (DO)endocrine gland cancer0.001807InformativeInherited
Disease Ontology (DO)liver disease0.005796InformativeInherited
Disease Ontology (DO)pancreas disease0.1587InformativeInherited
Disease Ontology (DO)hyperandrogenism0.00000008552Highly InformativeDirect
Disease Ontology (DO)endocrine pancreas disease0.000003655Highly InformativeDirect
Disease Ontology (DO)in situ carcinoma0.00008841Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.07998Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1432Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.239Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.3576Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.03277Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.03319Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.131Moderately InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0.1524Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of carbohydrate metabolism/homeostasis0.003992InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.0351InformativeInherited
Phenotypic Abnormality (PA)Motor delay0.0006309Highly InformativeDirect
Phenotypic Abnormality (PA)Intrauterine growth retardation0.0007779Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.04044Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1299Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.00005667Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal glucose homeostasis0.02398InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.0506InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.1192InformativeInherited
Mammalian Phenotype (MP)decreased birth weight0.000002498Highly InformativeDirect
Mammalian Phenotype (MP)decreased fetal size0.0007796Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.001211Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.00000002297Least InformativeDirect
Worm Phenotype (WP)cell development variant0.2128Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0000000006892Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.0007743Moderately InformativeDirect
Worm Phenotype (WP)body length variant0.0000000007462InformativeDirect
Worm Phenotype (WP)body width variant0.000000002058InformativeDirect
Worm Phenotype (WP)body posture variant0.0000005295InformativeDirect
Worm Phenotype (WP)localized movement variant0.00000667InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.00005674InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.0001969InformativeDirect
Worm Phenotype (WP)foraging behavior variant0.0002119InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.003095InformativeInherited
Worm Phenotype (WP)locomotion reduced0.8498InformativeInherited
Worm Phenotype (WP)dauer development variant0Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0.000000000002256Highly InformativeDirect
Worm Phenotype (WP)forward point velocity variant0.00000000001225Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.00000000001647Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0.000004372Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.0006494Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)mating defective0.0001391Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Moderately InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processOsteogenesis0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationToxin0.00000000000003044InformativeDirect
Post-translational modificationGrowth factor0Highly InformativeDirect
Post-translational modificationHormone0Highly InformativeDirect
Post-translational modificationMitogen0Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationCleavage on pair of basic residues0Moderately InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect
Post-translational modificationHydroxylation0.000000002104InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0Highly InformativeDirect
Post-translational modificationAmidation0.00000000002731Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Insulin-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the Insulin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]