SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Growth factor receptor domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   Growth factor receptor domain [ 57184]
Family:   Growth factor receptor domain [ 57185] (8)


Family statistics
Genomes (130) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,418 4,221 21
Proteins 1,035 2,959 14


Enzyme Commission (EC)

(
show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.0007136Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000002121Moderately InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Furin0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.005651Least InformativeInherited
Disease Ontology (DO)cell type cancer0.0004214Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.005034Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.03909Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.0516Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system cancer0.05413Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.06108Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.09088Moderately InformativeInherited
Disease Ontology (DO)liver carcinoma0.00001976InformativeDirect
Disease Ontology (DO)urinary system cancer0.00003346InformativeDirect
Disease Ontology (DO)physical disorder0.0001152InformativeDirect
Disease Ontology (DO)large intestine cancer0.0001715InformativeDirect
Disease Ontology (DO)osteosarcoma0.000173InformativeDirect
Disease Ontology (DO)interstitial lung disease0.0003726InformativeDirect
Disease Ontology (DO)glomerulonephritis0.0006389InformativeDirect
Disease Ontology (DO)lung carcinoma0.00064InformativeDirect
Disease Ontology (DO)malignant glioma0.000755InformativeDirect
Disease Ontology (DO)female reproductive organ cancer0.1419InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.1612InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.2181InformativeInherited
Disease Ontology (DO)neurofibroma0.00000002208Highly InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.000005917Highly InformativeDirect
Disease Ontology (DO)skin hemangioma0.00001083Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.0002157Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Incomplete penetrance0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.02753Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.00005749Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal vascular morphology0.0008085Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0.006264Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.2832Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac septum morphology0.00595InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac ventricle morphology0.05615InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve morphology0.2347InformativeInherited
Phenotypic Abnormality (PA)Abnormal adipose tissue morphology0.2451InformativeInherited
Phenotypic Abnormality (PA)Bicuspid aortic valve0.0004112Highly InformativeDirect
Phenotypic Abnormality (PA)Ventricular septal defect0.0009996Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.000004227Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.002724Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.08648Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.1873Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.3949Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4467Least InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.000001361Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.00001056Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.0003852Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.0006097Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.001216Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.002156Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.002377Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.004634Moderately InformativeInherited
Mammalian Phenotype (MP)adipose tissue phenotype0.0281Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.08347Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.1471Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.2828Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2851Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.2973Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3122Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.3253Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4328Moderately InformativeInherited
Mammalian Phenotype (MP)perinatal lethality0.000074InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.0007594InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0.01224InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.02988InformativeInherited
Mammalian Phenotype (MP)abnormal fat pad morphology0.07701InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.08816InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa physiology0.1094InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.1775InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.2137InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.2372InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.3416InformativeInherited
Mammalian Phenotype (MP)abnormal primary sex determination0.3571InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas physiology0.6165InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland physiology0.8426InformativeInherited
Mammalian Phenotype (MP)abnormal atrioventricular cushion morphology0.000004534Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0001174Highly InformativeDirect
Mammalian Phenotype (MP)impaired lung alveolus development0.0001174Highly InformativeDirect
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.0003059Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.0005977Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0006579Highly InformativeDirect
Mammalian Phenotype (MP)sex reversal0.0007109Highly InformativeDirect
Mammalian Phenotype (MP)abnormal insulin secretion0.02805Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.1946Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.4109Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.0006368Least InformativeDirect
Worm Phenotype (WP)cell development variant0.007612Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.02054Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.08735Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.08735Least InformativeInherited
Worm Phenotype (WP)larval lethal0.3727Least InformativeInherited
Worm Phenotype (WP)body region morphology variant0.0004877Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0004877Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.000491Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.0004942Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0.0005461Moderately InformativeDirect
Worm Phenotype (WP)cell type morphology variant0.9275Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.00002795InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.00009965InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.001512InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.01695InformativeInherited
Worm Phenotype (WP)loss of left right asymmetry0.0000009527Highly InformativeDirect
Worm Phenotype (WP)molt variant0.000002816Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.000004331Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.000004936Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0002704Highly InformativeDirect
Worm Phenotype (WP)myopodia present0.0004648Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective0.0002744InformativeDirect
Fly Phenotype (FP)planar polarity defective0.0003084InformativeDirect
Fly Phenotype (FP)immune response defective0.0008332InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.1191Least InformativeInherited
Fly Anatomy (FA)anatomical group0.2034Least InformativeInherited
Fly Anatomy (FA)segment0.2932Least InformativeInherited
Fly Anatomy (FA)tagma0.4295Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.4621Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.4762Least InformativeInherited
Fly Anatomy (FA)somatic cell0.6517Least InformativeInherited
Fly Anatomy (FA)adult0.7229Least InformativeInherited
Fly Anatomy (FA)cell cluster organ0.02942Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.06016Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.1307Moderately InformativeInherited
Fly Anatomy (FA)adult mesothoracic segment0.1618Moderately InformativeInherited
Fly Anatomy (FA)gonad0.1795Moderately InformativeInherited
Fly Anatomy (FA)appendage0.187Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.1973Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.2043Moderately InformativeInherited
Fly Anatomy (FA)adult head0.3811Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval tracheal system0.00003821InformativeDirect
Fly Anatomy (FA)chaeta0.00197InformativeInherited
Fly Anatomy (FA)adult external head0.003708InformativeInherited
Fly Anatomy (FA)anatomical space0.004906InformativeInherited
Fly Anatomy (FA)leg0.007945InformativeInherited
Fly Anatomy (FA)mesothoracic tergum0.01646InformativeInherited
Fly Anatomy (FA)appendage segment0.0195InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.04352InformativeInherited
Fly Anatomy (FA)embryonic/larval circulatory system0.06234InformativeInherited
Fly Anatomy (FA)mechanosensory system0.06356InformativeInherited
Fly Anatomy (FA)male organism0.08363InformativeInherited
Fly Anatomy (FA)adult head sensillum0.1001InformativeInherited
Fly Anatomy (FA)proventriculus0.00005455Highly InformativeDirect
Fly Anatomy (FA)integumentary specialisation0.000123Highly InformativeDirect
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0001666Highly InformativeDirect
Fly Anatomy (FA)primary lobe of embryonic/larval lymph gland0.0003161Highly InformativeDirect
Fly Anatomy (FA)hindgut0.0004873Highly InformativeDirect
Fly Anatomy (FA)germinal proliferation center0.0005561Highly InformativeDirect
Fly Anatomy (FA)dorsocentral bristle0.000751Highly InformativeDirect
Fly Anatomy (FA)stage 7 embryo0.0008005Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)anatomical cluster0.02049Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.3227Least InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.1625Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical conduit0.001442Highly InformativeInherited
Zebrafish Anatomy (ZA)inner ear0.1937Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0.04007Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.06427Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.126Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.1989Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.342Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.9431Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.000007426Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0003629Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.472Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.0000004476InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.00003171InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.00003984InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.00007016InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.00008471InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.0002771InformativeDirect
Xenopus ANatomical entity (XAN)animal hemisphere0.0006721InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.1754InformativeInherited
Xenopus ANatomical entity (XAN)fin0.0002278Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.00000000000535Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.001339Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.1255Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0.000000495InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.0007148InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 16 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Growth factor receptor domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]