SUPERFAMILY 1.75 HMM library and genome assignments server

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EGF-type module family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Knottins (small inhibitors, toxins, lectins) [ 57015] (19)
Superfamily:   EGF/Laminin [ 57196] (7)
Family:   EGF-type module [ 57197] (22)


Family statistics
Genomes (2) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3 9 3
Proteins 3 9 3


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.001093Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases1.746e-16Moderately InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s0.00000000008316Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r0.00000000008316Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4452Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.004467Moderately InformativeInherited
Disease Ontology (DO)artery disease0.07266Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.253Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.3154Moderately InformativeInherited
Disease Ontology (DO)pancreas disease0.04101InformativeInherited
Disease Ontology (DO)primary thrombocytopenia0.00003425Highly InformativeDirect
Disease Ontology (DO)gastritis0.0006161Highly InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm0.0009948Highly InformativeDirect
Disease Ontology (DO)pancreatitis0.005763Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.004966Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.1958Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.3523Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.4935Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.0211Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.02488Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.1114Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.2969Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac septum morphology0.0005645InformativeDirect
Phenotypic Abnormality (PA)Hernia0.003011InformativeInherited
Phenotypic Abnormality (PA)Abnormal uvea morphology0.003392InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac ventricle morphology0.01757InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve physiology0.1075InformativeInherited
Phenotypic Abnormality (PA)Abnormal fundus morphology0.9769InformativeInherited
Phenotypic Abnormality (PA)Ventricular septal defect0.00001887Highly InformativeDirect
Phenotypic Abnormality (PA)Hernia of the abdominal wall0.00003583Highly InformativeDirect
Phenotypic Abnormality (PA)Aortic valve stenosis0.0007546Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormally lax or hyperextensible skin0.0009932Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.000001152Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.02568Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.06483Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1276Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1457Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.2536Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.3386Least InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.0001389Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.001083Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.002963Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.01147Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.01219Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.03256Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.08173Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.1061Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.3197Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.3371Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.3603Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.3674Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.3942Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.5281Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.5649Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.6401Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.7684Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.8091Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.0000001188InformativeDirect
Mammalian Phenotype (MP)abnormal coat appearance0.004442InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.01974InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.03556InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system tract morphology0.04248InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.05288InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.06075InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa physiology0.06758InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.1218InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.1339InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.1409InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.1721InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.1744InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.1818InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.2189InformativeInherited
Mammalian Phenotype (MP)abnormal cell migration0.3058InformativeInherited
Mammalian Phenotype (MP)abnormal bone ossification0.3949InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.484InformativeInherited
Mammalian Phenotype (MP)abnormal aorta tunica media morphology0.00001619Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord ventral commissure morphology0.00002994Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pregnancy0.00007089Highly InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte adhesion0.0002172Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tendon morphology0.0003045Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.000579Highly InformativeDirect
Mammalian Phenotype (MP)impaired lung alveolus development0.0005979Highly InformativeDirect
Mammalian Phenotype (MP)increased sensory neuron number0.000633Highly InformativeDirect
Mammalian Phenotype (MP)microphthalmia0.0006503Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord white matter morphology0.0188Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell number0.03074Highly InformativeInherited
Mammalian Phenotype (MP)increased bone mass0.06343Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear inner hair cell morphology0.2561Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle tissue morphology0.2968Highly InformativeInherited
Mammalian Phenotype (MP)skin lesions0.3474Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone mineralization0.3688Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory ganglion morphology0.4327Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.1389Least InformativeInherited
Worm Phenotype (WP)movement variant0.001332Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.02447Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.03516Moderately InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.01781InformativeInherited
Worm Phenotype (WP)intestinal development variant0.0009544Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.1773Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.004184Moderately InformativeInherited
Fly Phenotype (FP)planar polarity defective0.000008555InformativeDirect
Fly Phenotype (FP)cell polarity defective0.0001498InformativeDirect
Fly Phenotype (FP)size defective0.009612InformativeInherited
Fly Phenotype (FP)increased occurrence of cell division0.00003323Highly InformativeDirect
Fly Phenotype (FP)decreased occurrence of cell division0.0003577Highly InformativeDirect
Fly Phenotype (FP)some die during pupal stage0.0007566Highly InformativeDirect
Fly Phenotype (FP)neoplasia0.02911Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)segment0.1075Least InformativeInherited
Fly Anatomy (FA)anatomical group0.2206Least InformativeInherited
Fly Anatomy (FA)larva0.2245Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.2948Least InformativeInherited
Fly Anatomy (FA)tagma0.3598Least InformativeInherited
Fly Anatomy (FA)adult0.4158Least InformativeInherited
Fly Anatomy (FA)somatic cell0.5075Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.5941Least InformativeInherited
Fly Anatomy (FA)nervous system0.637Least InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.00001626Moderately InformativeDirect
Fly Anatomy (FA)late embryo0.0006011Moderately InformativeDirect
Fly Anatomy (FA)epithelium0.005222Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.02857Moderately InformativeInherited
Fly Anatomy (FA)appendage0.02884Moderately InformativeInherited
Fly Anatomy (FA)adult mesothoracic segment0.04927Moderately InformativeInherited
Fly Anatomy (FA)gonad0.07081Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1355Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.2015Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.3257Moderately InformativeInherited
Fly Anatomy (FA)adult head0.3546Moderately InformativeInherited
Fly Anatomy (FA)wing blade0.000143InformativeDirect
Fly Anatomy (FA)adult external head0.0003024InformativeDirect
Fly Anatomy (FA)adult heart0.00039InformativeDirect
Fly Anatomy (FA)embryonic/larval tracheal system0.0003964InformativeDirect
Fly Anatomy (FA)anatomical space0.0004864InformativeDirect
Fly Anatomy (FA)antennal segment0.001326InformativeInherited
Fly Anatomy (FA)embryonic/larval digestive system0.006177InformativeInherited
Fly Anatomy (FA)cuticle0.009686InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.01176InformativeInherited
Fly Anatomy (FA)midgut0.0162InformativeInherited
Fly Anatomy (FA)embryonic/larval circulatory system0.01752InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.02188InformativeInherited
Fly Anatomy (FA)syncytium0.02924InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.03952InformativeInherited
Fly Anatomy (FA)muscle cell0.04243InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.1035InformativeInherited
Fly Anatomy (FA)male organism0.3197InformativeInherited
Fly Anatomy (FA)ventral nervous system0.000009824Highly InformativeDirect
Fly Anatomy (FA)proventriculus0.00004081Highly InformativeDirect
Fly Anatomy (FA)primary lobe of embryonic/larval lymph gland0.0002495Highly InformativeDirect
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0003636Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0.000579Highly InformativeDirect
Fly Anatomy (FA)hindgut0.0006029Highly InformativeDirect
Fly Anatomy (FA)endocuticle0.0007224Highly InformativeDirect
Fly Anatomy (FA)somatic cell of testis0.0007224Highly InformativeDirect
Fly Anatomy (FA)germinal proliferation center0.006977Highly InformativeInherited
Fly Anatomy (FA)acute muscle0.06045Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval midgut0.2557Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.0004529Least InformativeDirect
Zebrafish Anatomy (ZA)anatomical cluster0.4117Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.8119Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.09248Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.9906Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical conduit0.0005786Highly InformativeDirect
Zebrafish Anatomy (ZA)pars superior ear0.00184Highly InformativeInherited
Zebrafish Anatomy (ZA)epithelium0.117Highly InformativeInherited
Zebrafish Anatomy (ZA)cranial ganglion0.5053Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.0004526InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.00009043Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.0003175Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0.1627Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 83 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a EGF/Laminin domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]