SUPERFAMILY 1.75 HMM library and genome assignments server

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Extracellular domain of cell surface receptors family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Snake toxin-like [ 57301]
Superfamily:   Snake toxin-like [ 57302] (3)
Family:   Extracellular domain of cell surface receptors [ 57354] (6)


Family statistics
Genomes (66) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 442 1,240 32
Proteins 410 1,130 24


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)artery disease0.00001349Moderately InformativeDirect
Disease Ontology (DO)nervous system cancer0.00005036Moderately InformativeDirect
Disease Ontology (DO)retinal cell cancer0.0000005128InformativeDirect
Disease Ontology (DO)lung carcinoma0.0002943InformativeDirect
Disease Ontology (DO)urinary system cancer0.03151InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.5184InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.2Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2195Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.004145Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.02119Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.1238Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the uterus0.0005808InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac ventricle morphology0.0005992InformativeDirect
Phenotypic Abnormality (PA)Abnormal morphology of the great vessels0.0006984InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0009707Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.01057Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.01829Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.01854Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.02989Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.00001438Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal embryo morphology0.0001544Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system morphology0.0009289Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.001097Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.003999Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.01089Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.02062Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.05933Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.09147Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.09796Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1118Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.4218Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.4587Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.00006349InformativeDirect
Mammalian Phenotype (MP)abnormal ovary morphology0.002351InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.003265InformativeInherited
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0.003662InformativeInherited
Mammalian Phenotype (MP)abnormal jaw morphology0.00735InformativeInherited
Mammalian Phenotype (MP)lethality throughout fetal growth and development0.009565InformativeInherited
Mammalian Phenotype (MP)abnormal bone ossification0.2612InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.2734InformativeInherited
Mammalian Phenotype (MP)abnormal mouth morphology0.4229InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology0.0000003032Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal ganglion cell morphology0.00007387Highly InformativeDirect
Mammalian Phenotype (MP)embryonic lethality between implantation and somite formation, complete penetrance0.0001085Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rostral-caudal axis patterning0.0002083Highly InformativeDirect
Mammalian Phenotype (MP)lethality throughout fetal growth and development, complete penetrance0.0002949Highly InformativeDirect
Mammalian Phenotype (MP)abnormal uterus morphology0.0006518Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tooth morphology0.0007488Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gastrulation0.00401Highly InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic tissue physiology0.01441Highly InformativeInherited
Mammalian Phenotype (MP)abnormal germ layer morphology0.01496Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0Moderately InformativeDirect
Fly Phenotype (FP)wild-type0InformativeDirect
Fly Phenotype (FP)size defective0InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0InformativeDirect
Fly Phenotype (FP)decreased cell number0.0002036InformativeDirect
Fly Phenotype (FP)decreased occurrence of cell division0.000125Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)larval tagma0Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0Moderately InformativeDirect
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)ganglion0Moderately InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0Moderately InformativeDirect
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0.006622Moderately InformativeInherited
Fly Anatomy (FA)adult head0.2333Moderately InformativeInherited
Fly Anatomy (FA)leg0InformativeDirect
Fly Anatomy (FA)embryonic/larval peripheral nervous system0InformativeDirect
Fly Anatomy (FA)cell component0InformativeDirect
Fly Anatomy (FA)segmental subdivision of organ system0InformativeDirect
Fly Anatomy (FA)embryonic/larval tracheal system0.0009015InformativeDirect
Fly Anatomy (FA)appendage segment0.001245InformativeInherited
Fly Anatomy (FA)labral segment0.001312InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.001894InformativeInherited
Fly Anatomy (FA)synaptic neuropil block0.005059InformativeInherited
Fly Anatomy (FA)adult central nervous system0.02368InformativeInherited
Fly Anatomy (FA)brain0.04863InformativeInherited
Fly Anatomy (FA)embryonic/larval neuromuscular junction0Highly InformativeDirect
Fly Anatomy (FA)adult protocerebrum0.0003578Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0.6656Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.08728Moderately InformativeInherited
Zebrafish Anatomy (ZA)vasculature0.08263InformativeInherited
Zebrafish Anatomy (ZA)post-vent region0.1055InformativeInherited
Zebrafish Anatomy (ZA)endothelial cell0.0001957Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0.5099Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.5294Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.001629Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.2989Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neuroectoderm0InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.0000002922InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.00003732InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.000042InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0001164InformativeDirect
Xenopus ANatomical entity (XAN)animal hemisphere0.0002137InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0009379InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.0009883InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0.07046InformativeInherited
Xenopus ANatomical entity (XAN)head mesoderm0.000000006253Highly InformativeDirect
Xenopus ANatomical entity (XAN)head mesenchyme0.0000001228Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.000001058Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.000008038Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.00003554Highly InformativeDirect
Xenopus ANatomical entity (XAN)splanchnocranium0.0001523Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 57 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Snake toxin-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]