SUPERFAMILY 1.75 HMM library and genome assignments server

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Fibronectin type II module family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Kringle-like [ 57439]
Superfamily:   Kringle-like [ 57440] (2)
Family:   Fibronectin type II module [ 57459] (4)


Family statistics
Genomes (59) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 384 1,059 16
Proteins 187 508 9


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.3704Moderately InformativeInherited
Enzyme Commission (EC)Metalloendopeptidases0.0000000000116InformativeDirect
Enzyme Commission (EC)Gelatinase A0.000000000174Highly InformativeDirect
Enzyme Commission (EC)Gelatinase B0.000000000174Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.01527Least InformativeInherited
Disease Ontology (DO)genetic disease0.008847Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.01722Moderately InformativeInherited
Disease Ontology (DO)artery disease0.02292Moderately InformativeInherited
Disease Ontology (DO)osteosarcoma0.00008702InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.0003377InformativeDirect
Disease Ontology (DO)atherosclerosis0.0005936InformativeDirect
Disease Ontology (DO)coronary artery disease0.0006371InformativeDirect
Disease Ontology (DO)myeloid neoplasm0.0007153InformativeDirect
Disease Ontology (DO)head and neck carcinoma0.001747InformativeInherited
Disease Ontology (DO)lymphoma0.005317InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.03937InformativeInherited
Disease Ontology (DO)acute myocardial infarction0.000002239Highly InformativeDirect
Disease Ontology (DO)Hodgkin's lymphoma0.00002977Highly InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0.00005199Highly InformativeDirect
Disease Ontology (DO)thyroid carcinoma0.000731Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.1831Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.421Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.0777Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.006887InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.05847Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.2307Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2323Least InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.001644Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.01621Moderately InformativeInherited
Mammalian Phenotype (MP)increased sensitivity to induced morbidity/mortality0.0004934InformativeDirect
Mammalian Phenotype (MP)abnormal response to injury0.01031InformativeInherited
Mammalian Phenotype (MP)altered response to CNS ischemic injury0.0000482Highly InformativeDirect
Mammalian Phenotype (MP)decreased susceptibility to infection0.0006249Highly InformativeDirect

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)anatomical cluster0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.6295Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.0008028InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.0008108InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.3855InformativeInherited
Enzyme Commission (EC)Metalloendopeptidases0.000000000003376Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 30 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Kringle-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]