SUPERFAMILY 1.75 HMM library and genome assignments server

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Gonadodropin/Follitropin family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cystine-knot cytokines [ 57500]
Superfamily:   Cystine-knot cytokines [ 57501] (7)
Family:   Gonadodropin/Follitropin [ 57528] (3)


Family statistics
Genomes (60) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 224 880 5
Proteins 224 880 5


Human Phenotype (HP)

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show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the endocrine system0Moderately InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.05449Least InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.001668Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2963Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal ovary morphology0.0001171InformativeDirect
Mammalian Phenotype (MP)abnormal male reproductive system physiology0.0001386InformativeDirect
Mammalian Phenotype (MP)abnormal primary sex determination0.0007909InformativeDirect
Mammalian Phenotype (MP)abnormal spermatogenesis0.0009042InformativeDirect
Mammalian Phenotype (MP)abnormal testis morphology0.001322InformativeInherited
Mammalian Phenotype (MP)abnormal corpus luteum morphology0.000004129Highly InformativeDirect
Mammalian Phenotype (MP)abnormal uterus morphology0.00002874Highly InformativeDirect
Mammalian Phenotype (MP)abnormal seminiferous tubule morphology0.0001916Highly InformativeDirect
Mammalian Phenotype (MP)small testis0.0005464Highly InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Cystine-knot cytokines domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Internal database links ]