SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Complement control module/SCR domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Complement control module/SCR domain [ 57534]
Superfamily:   Complement control module/SCR domain [ 57535]
Family:   Complement control module/SCR domain [ 57536] (14)


Family statistics
Genomes (50) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,106 3,251 81
Proteins 579 1,581 40


Enzyme Commission (EC)

(
show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.4674Least InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0.0000000000000109Moderately InformativeDirect
Enzyme Commission (EC)Peroxidases0.0000001529InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s0.00000000001395Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r0.00000000001395Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.05548Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.00000007488Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.0005859Moderately InformativeDirect
Disease Ontology (DO)syndrome0.0005945Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.02564Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.06968Moderately InformativeInherited
Disease Ontology (DO)glomerulonephritis0.00004655InformativeDirect
Disease Ontology (DO)eye disease0.0004115InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.01074InformativeInherited
Disease Ontology (DO)hemorrhagic disease0.9339InformativeInherited
Disease Ontology (DO)anemia0.1636Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.002736Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1789Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.1898Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.4158Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.7284Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.9758Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.9935Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.008204Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.1338Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.1401Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.1946Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.3511Moderately InformativeInherited
Phenotypic Abnormality (PA)Unusual infection0.3973Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.4755Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.8585Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of complement system0.00001057InformativeDirect
Phenotypic Abnormality (PA)Abnormal platelet count0.0001516InformativeDirect
Phenotypic Abnormality (PA)Azotemia0.0001615InformativeDirect
Phenotypic Abnormality (PA)Abnormal urine cytology0.0007202InformativeDirect
Phenotypic Abnormality (PA)Anemia0.0008926InformativeDirect
Phenotypic Abnormality (PA)Recurrent infections0.003214InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.01861InformativeInherited
Phenotypic Abnormality (PA)Edema0.05512InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.5678InformativeInherited
Phenotypic Abnormality (PA)Neurological speech impairment0.5959InformativeInherited
Phenotypic Abnormality (PA)Abnormal fundus morphology0.6581InformativeInherited
Phenotypic Abnormality (PA)Recurrent Neisserial infections0.000001824Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal urine output0.000002423Highly InformativeDirect
Phenotypic Abnormality (PA)Yellow/white lesions of the retina0.0004488Highly InformativeDirect
Phenotypic Abnormality (PA)Renal insufficiency0.0006134Highly InformativeDirect
Phenotypic Abnormality (PA)Diarrhea0.0007277Highly InformativeDirect
Phenotypic Abnormality (PA)Poikilocytosis0.03125Highly InformativeInherited
Phenotypic Abnormality (PA)Hemolytic anemia1Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.0647Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.2484Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.7463Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.01549Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic transmission0.08106Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.9461Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal innate immunity0.000184InformativeDirect
Mammalian Phenotype (MP)abnormal innervation0.01974InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.05164InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.08743InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.1282InformativeInherited
Mammalian Phenotype (MP)abnormal cell migration0.1528InformativeInherited
Mammalian Phenotype (MP)abnormal cervical lymph node morphology0.00006162Highly InformativeDirect
Mammalian Phenotype (MP)decreased excitatory postsynaptic current amplitude0.0001139Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cellular extravasation0.03288Highly InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte adhesion0.04054Highly InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte physiology0.07984Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Least InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)post-embryonic stage0.5755Least InformativeInherited
Xenopus DEvelopment stage (XDE)premetamorphosis stage0.01696Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.4141Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.0000000000000162InformativeDirect
Enzyme Commission (EC)Peroxidases0.0000001366Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 44 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Complement control module/SCR domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]