|
|
Methylamine dehydrogenase, L chain superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Metabolism |
| Detailed category | E- transfer |
Function annotation of SCOP domain superfamilies
InterPro annotation
| Cross references | IPR013504 SSF57561 Protein matches |
| Abstract | Methylamine dehydrogenase is a periplasmic quinoprotein found in several methylotrophic bacteria [ 8021187]. It is induced when grown on methylamine as a carbon source MADH and catalyses the oxidative deamination of amines to their corresponding aldehydes. The redox cofactor of this enzyme is tryptophan tryptophylquinone (TTQ). Electrons derived from the oxidation of methylamine are passed to an electron acceptor, which is usually the blue-copper protein amicyanin .
RCH2NH2 + H2O + acceptor = RCHO + NH3 + reduced acceptor
MADH is a hetero-tetramer, comprised of two heavy subunits and two light subunits. The light subunit forms two antiparallel beta sheets, and contains the active site of this enzyme which is accessible via a hydrophobic channel between the heavy and light subunits. The redox cofactor TTQ is formed from two posttranlationally modified tryptophan residues within this subunit [9514722]. |
InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
|
Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
|
Alignments of sequences to 2 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
|
|
Browse and view proteins in genomes which have
different domain combinations including a Methylamine dehydrogenase, L chain domain.
|
Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
|
|
Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
|
There are 2 hidden Markov models representing the Methylamine dehydrogenase, L chain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
|
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]
|
0
