SUPERFAMILY 1.75 HMM library and genome assignments server

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TNF receptor-like family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   TNF receptor-like [ 57585]
Superfamily:   TNF receptor-like [ 57586] (2)
Family:   TNF receptor-like [ 57587] (5)


Family statistics
Genomes (32) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 156 393 19
Proteins 120 285 10


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.006323Least InformativeInherited
Disease Ontology (DO)nervous system disease0.5745Least InformativeInherited
Disease Ontology (DO)connective tissue disease0.00000000000101Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.0000007239Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.0000009591Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.000005252Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.00004813Moderately InformativeDirect
Disease Ontology (DO)integumentary system disease0.000161Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.004173Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.008729Moderately InformativeInherited
Disease Ontology (DO)artery disease0.6807Moderately InformativeInherited
Disease Ontology (DO)arthritis0.0000000000009404InformativeDirect
Disease Ontology (DO)lupus erythematosus0.0000000006775InformativeDirect
Disease Ontology (DO)breast carcinoma0.00002527InformativeDirect
Disease Ontology (DO)multiple sclerosis0.0001273InformativeDirect
Disease Ontology (DO)hypotrichosis0.0001443InformativeDirect
Disease Ontology (DO)atherosclerosis0.0002617InformativeDirect
Disease Ontology (DO)myeloid neoplasm0.0003402InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.0009399InformativeDirect
Disease Ontology (DO)endocrine gland cancer0.02862InformativeInherited
Disease Ontology (DO)arthropathy0.1112InformativeInherited
Disease Ontology (DO)Graves' disease0.0007054Highly InformativeDirect
Disease Ontology (DO)primary immunodeficiency disease0.05408Highly InformativeInherited
Disease Ontology (DO)bone remodeling disease0.1381Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.03001Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.06209Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.08287Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.09639Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.509Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.0001996Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.0191Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.03304Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.03361Moderately InformativeInherited
Phenotypic Abnormality (PA)Splenomegaly0.0001123InformativeDirect
Phenotypic Abnormality (PA)Abnormal cellular physiology0.0009945InformativeDirect
Phenotypic Abnormality (PA)Subcutaneous nodule0.0009902Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.000002446Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.000003257Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.01048Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3481Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.5111Least InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.00000000591Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.000000006679Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.00000004073Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal bone structure0.00007259Moderately InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to infection0.0005267Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.002491Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.002723Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.01426Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.02Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.02Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.03479Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.05298Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.06477Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.07029Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.08697Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.1589Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.2621Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.3064Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.3463Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.6031Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.6316Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.7851Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interferon-gamma secretion0.000011InformativeDirect
Mammalian Phenotype (MP)abnormal jaw morphology0.0009907InformativeDirect
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.002479InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.00649InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.008982InformativeInherited
Mammalian Phenotype (MP)increased lymphocyte cell number0.009375InformativeInherited
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.01141InformativeInherited
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.01399InformativeInherited
Mammalian Phenotype (MP)abnormal immunoglobulin level0.01754InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.027InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.0534InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.1329InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.1423InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to autoimmune disorder0.3365InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.3606InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.3635InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.3865InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.4634InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.6126InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0.7315InformativeInherited
Mammalian Phenotype (MP)abnormal spleen germinal center morphology0.000000000000149Highly InformativeDirect
Mammalian Phenotype (MP)decreased acute inflammation0.00000006578Highly InformativeDirect
Mammalian Phenotype (MP)decreased susceptibility to experimental autoimmune encephalomyelitis0.00002355Highly InformativeDirect
Mammalian Phenotype (MP)abnormal IgG2b level0.00002741Highly InformativeDirect
Mammalian Phenotype (MP)enlarged spleen0.0000321Highly InformativeDirect
Mammalian Phenotype (MP)abnormal T cell proliferation0.0000358Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.00004892Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.00007747Highly InformativeDirect
Mammalian Phenotype (MP)skin lesions0.00008467Highly InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to bacterial infection0.0001357Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cytotoxic T cell physiology0.0003016Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body temperature homeostasis0.0003232Highly InformativeDirect
Mammalian Phenotype (MP)altered response to CNS ischemic injury0.0004643Highly InformativeDirect
Mammalian Phenotype (MP)enlarged lymph nodes0.000479Highly InformativeDirect
Mammalian Phenotype (MP)lung inflammation0.000597Highly InformativeDirect
Mammalian Phenotype (MP)abnormal myelination0.0006132Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus size0.616Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 22 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a TNF receptor-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]