SUPERFAMILY 1.75 HMM library and genome assignments server

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TNF receptor-like family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   TNF receptor-like [ 57585]
Superfamily:   TNF receptor-like [ 57586] (2)
Family:   TNF receptor-like [ 57587] (5)


Family statistics
Genomes (32) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 156 393 19
Proteins 120 285 10


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.006323Least InformativeInherited
Disease Ontology (DO)nervous system disease0.5745Least InformativeInherited
Disease Ontology (DO)connective tissue disease0.00000000000101Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.0000007239Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.0000009591Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.000005252Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.00004813Moderately InformativeDirect
Disease Ontology (DO)integumentary system disease0.000161Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.004173Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.008729Moderately InformativeInherited
Disease Ontology (DO)artery disease0.6807Moderately InformativeInherited
Disease Ontology (DO)arthritis0.0000000000009404InformativeDirect
Disease Ontology (DO)lupus erythematosus0.0000000006775InformativeDirect
Disease Ontology (DO)breast carcinoma0.00002527InformativeDirect
Disease Ontology (DO)multiple sclerosis0.0001273InformativeDirect
Disease Ontology (DO)hypotrichosis0.0001443InformativeDirect
Disease Ontology (DO)atherosclerosis0.0002617InformativeDirect
Disease Ontology (DO)myeloid neoplasm0.0003402InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.0009399InformativeDirect
Disease Ontology (DO)endocrine gland cancer0.02862InformativeInherited
Disease Ontology (DO)arthropathy0.1112InformativeInherited
Disease Ontology (DO)Graves' disease0.0007054Highly InformativeDirect
Disease Ontology (DO)primary immunodeficiency disease0.05408Highly InformativeInherited
Disease Ontology (DO)bone remodeling disease0.1381Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.0285Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.06198Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.07917Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.09031Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.5028Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.0001813Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.03097Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.03199Moderately InformativeInherited
Phenotypic Abnormality (PA)Splenomegaly0.000104InformativeDirect
Phenotypic Abnormality (PA)Abnormal cellular physiology0.0009087InformativeDirect
Phenotypic Abnormality (PA)Subcutaneous nodule0.0009755Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.000002439Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.000003246Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.01049Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3479Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.5112Least InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.000000005837Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.000000006597Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.00000004028Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal bone structure0.00007264Moderately InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to infection0.0005267Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.002492Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.002705Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.01426Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.0199Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.02001Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.03481Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.05277Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.06454Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.07045Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.08697Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.1589Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.2615Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.3059Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.3473Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.6023Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.6322Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.7859Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interferon-gamma secretion0.00001102InformativeDirect
Mammalian Phenotype (MP)abnormal jaw morphology0.000991InformativeDirect
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.002478InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.006527InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.008998InformativeInherited
Mammalian Phenotype (MP)increased lymphocyte cell number0.009305InformativeInherited
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.01132InformativeInherited
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.01398InformativeInherited
Mammalian Phenotype (MP)abnormal immunoglobulin level0.01736InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.02685InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.05308InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.1329InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.1422InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to autoimmune disorder0.3364InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.3615InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.3628InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.3864InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.4635InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.6148InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0.7305InformativeInherited
Mammalian Phenotype (MP)abnormal spleen germinal center morphology0.0000000000001332Highly InformativeDirect
Mammalian Phenotype (MP)decreased acute inflammation0.00000006586Highly InformativeDirect
Mammalian Phenotype (MP)decreased susceptibility to experimental autoimmune encephalomyelitis0.00002358Highly InformativeDirect
Mammalian Phenotype (MP)abnormal IgG2b level0.00002744Highly InformativeDirect
Mammalian Phenotype (MP)enlarged spleen0.00003164Highly InformativeDirect
Mammalian Phenotype (MP)abnormal T cell proliferation0.00003584Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.00004897Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.00007748Highly InformativeDirect
Mammalian Phenotype (MP)skin lesions0.00008466Highly InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to bacterial infection0.0001358Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cytotoxic T cell physiology0.0003015Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body temperature homeostasis0.0003234Highly InformativeDirect
Mammalian Phenotype (MP)altered response to CNS ischemic injury0.0004648Highly InformativeDirect
Mammalian Phenotype (MP)enlarged lymph nodes0.0004792Highly InformativeDirect
Mammalian Phenotype (MP)lung inflammation0.0005972Highly InformativeDirect
Mammalian Phenotype (MP)abnormal myelination0.000613Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus size0.617Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 22 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a TNF receptor-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]