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FnI-like domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   FnI-like domain [ 57602]
Superfamily:   FnI-like domain [ 57603] (2)
Families:   Fibronectin type I module [ 57604] (2)
  VWC domain [ 118264]


Superfamily statistics
Genomes (147) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 10,295 27,002 13
Proteins 3,823 10,540 9


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.00000000009655Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.007355Least InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0.000000000000004396Moderately InformativeDirect
Enzyme Commission (EC)Peroxidases0.0000000001346InformativeDirect
Enzyme Commission (EC)T-plasminogen activator0Highly InformativeDirect
Enzyme Commission (EC)Peroxidase0.000000000000001637Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1039Least InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.003425Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.2757Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.3437Moderately InformativeInherited
Disease Ontology (DO)arthritis0.00001555InformativeDirect
Disease Ontology (DO)collagen disease0.05242InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.06883InformativeInherited
Disease Ontology (DO)neurofibroma0.000002421Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.05577Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1757Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.3049Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.3955Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.4568Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.682Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.747Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.04871Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.06501Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.1104Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.2259Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.3206Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal posterior eye segment morphology0.3342Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.3794Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.3858Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.4284Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.5533Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.6173Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.04792InformativeInherited
Phenotypic Abnormality (PA)Hernia0.05708InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.07271InformativeInherited
Phenotypic Abnormality (PA)Abnormal retinal morphology0.1091InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lens0.1188InformativeInherited
Phenotypic Abnormality (PA)Short stature0.2015InformativeInherited
Phenotypic Abnormality (PA)Abnormal lower limb bone morphology0.209InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.3109InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.34InformativeInherited
Phenotypic Abnormality (PA)Mitral valve prolapse0.000006425Highly InformativeDirect
Phenotypic Abnormality (PA)Ectopia lentis0.0002251Highly InformativeDirect
Phenotypic Abnormality (PA)Dermal atrophy0.002166Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal wall0.01563Highly InformativeInherited
Phenotypic Abnormality (PA)Proportionate short stature0.0211Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of femur morphology0.04767Highly InformativeInherited
Phenotypic Abnormality (PA)Dilatation0.09899Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal aortic morphology0.1459Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of epiphysis morphology0.2236Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.0007124Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.1053Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1864Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.00002233Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.0007717Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.004566Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.005419Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.009127Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.01535Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.23Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.2439Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.5465Moderately InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.000001183InformativeDirect
Mammalian Phenotype (MP)abnormal angiogenesis0.00002815InformativeDirect
Mammalian Phenotype (MP)abnormal response to injury0.0002906InformativeDirect
Mammalian Phenotype (MP)abnormal head morphology0.009241InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.01366InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.03064InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.1082InformativeInherited
Mammalian Phenotype (MP)abnormal bone ossification0.1235InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.1341InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.2468InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.396InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.6452InformativeInherited
Mammalian Phenotype (MP)abnormal kidney corticomedullary boundary morphology0.000001603Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib morphology0.00007385Highly InformativeDirect
Mammalian Phenotype (MP)microphthalmia0.0003315Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development0.0004084Highly InformativeDirect
Mammalian Phenotype (MP)abnormal compact bone thickness0.0004258Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.0009894Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pulmonary alveolus morphology0.004163Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skin tensile strength0.004922Highly InformativeInherited
Mammalian Phenotype (MP)abnormal kidney size0.05505Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pulmonary circulation0.06079Highly InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory epithelium morphology0.106Highly InformativeInherited
Mammalian Phenotype (MP)internal hemorrhage0.5946Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.1868Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.2864Least InformativeInherited
Zebrafish Anatomy (ZA)head0.1546Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.1743Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal system0.000003835InformativeDirect
Zebrafish Anatomy (ZA)pharyngeal arch0.02004InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.09739InformativeInherited
Zebrafish Anatomy (ZA)pectoral fin0.0003063Highly InformativeDirect
Zebrafish Anatomy (ZA)suspensorium0.001157Highly InformativeInherited
Zebrafish Anatomy (ZA)mandibular arch skeleton0.001659Highly InformativeInherited
Zebrafish Anatomy (ZA)median fin fold0.009473Highly InformativeInherited
Zebrafish Anatomy (ZA)oral region0.01647Highly InformativeInherited
Zebrafish Anatomy (ZA)bone element0.1888Highly InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch cartilage0.3125Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.5767Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.7072Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.2754Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.3632Moderately InformativeInherited
Xenopus ANatomical entity (XAN)endoderm0.00001444InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.0001372InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.001938InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.0211InformativeInherited
Xenopus ANatomical entity (XAN)hypochord0.00000006505Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.00007409Highly InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.0004172Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.0007356Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelial cell0.0008832Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.0009729Highly InformativeDirect
Xenopus ANatomical entity (XAN)axial mesoderm0.005831Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0002459Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.00587Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.00000000006655Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0.000000000000003004InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.0000000001241InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a FnI-like domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the FnI-like domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]