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beta-beta-alpha zinc fingers superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   beta-beta-alpha zinc fingers [ 57666]
Superfamily:   beta-beta-alpha zinc fingers [ 57667] (7)
Families:   Classic zinc finger, C2H2 [ 57668] (30)
  Plant C2H2 finger (QALGGH zinc finger) [ 90198]
  C2HC finger [ 57697] (3)
  HkH motif-containing C2H2 finger [ 111436] (4)
  CHHC finger [ 161158]
  variant C2H2 finger [ 118273]
  BED zinc finger [ 144157]


Superfamily statistics
Genomes (573) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 283,318 732,602 212
Proteins 83,479 249,271 173


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.0001316Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.0006257Least InformativeDirect
Enzyme Commission (EC)Methyltransferases0.0000000003713Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000000001404InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase2.368e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.9352Least InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.115Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.666Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.1864InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.000004687Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0006987Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.001176Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.04378Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.4045Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.923Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.9382Moderately InformativeInherited
Worm Phenotype (WP)cell number increased0.000000003306InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.0002272InformativeDirect
Worm Phenotype (WP)protruding vulva0.0005113InformativeDirect
Worm Phenotype (WP)male morphology variant0.0006112InformativeDirect
Worm Phenotype (WP)egg laying variant0.1295InformativeInherited
Worm Phenotype (WP)drug resistant0.2531InformativeInherited
Worm Phenotype (WP)chemical resistant0.4885InformativeInherited
Worm Phenotype (WP)multiple anchor cells0.00004132Highly InformativeDirect
Worm Phenotype (WP)imipramine resistant0.0004139Highly InformativeDirect
Worm Phenotype (WP)sex determination variant0.2004Highly InformativeInherited
Worm Phenotype (WP)postembryonic cell lineage variant0.223Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organism subdivision0.0000000175Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.000001014Least InformativeDirect
Fly Anatomy (FA)adult0.000001208Least InformativeDirect
Fly Anatomy (FA)larva1Least InformativeInherited
Fly Anatomy (FA)nervous system1Least InformativeInherited
Fly Anatomy (FA)cell1Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure1Least InformativeInherited
Fly Anatomy (FA)adult integumentary system0Moderately InformativeDirect
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)region of integument0Moderately InformativeDirect
Fly Anatomy (FA)thorax0.000000000000001905Moderately InformativeDirect
Fly Anatomy (FA)adult segment0.000000000000003801Moderately InformativeDirect
Fly Anatomy (FA)adult tagma0.00000000001968Moderately InformativeDirect
Fly Anatomy (FA)central nervous system1Moderately InformativeInherited
Fly Anatomy (FA)neuron1Moderately InformativeInherited
Fly Anatomy (FA)ganglion1Moderately InformativeInherited
Fly Anatomy (FA)subesophageal ganglion0.01747Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.3357Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.7103Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.821Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.9235Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.3639Moderately InformativeInherited
Zebrafish Anatomy (ZA)forebrain0.2833InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.5657Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.1202Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.2214Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.01187InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.1938InformativeInherited
Xenopus ANatomical entity (XAN)anterior neural ridge0.00006514Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.0002351Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.002993Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0001841Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)late tailbud stage0.03468InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 100.000122Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot axis0.7781Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)root tip0.0003773InformativeDirect
Plant ANatomical entity (PAN)reproductive shoot apex0.0002415Highly InformativeDirect
Plant ANatomical entity (PAN)primary root0.0004596Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.00001814Moderately InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0.003957Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0.00000000003466InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase0.0000000000000222Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 99 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a beta-beta-alpha zinc fingers domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 99 hidden Markov models representing the beta-beta-alpha zinc fingers superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]