SUPERFAMILY 1.75 HMM library and genome assignments server

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Classic zinc finger, C2H2 family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   beta-beta-alpha zinc fingers [ 57666]
Superfamily:   beta-beta-alpha zinc fingers [ 57667] (7)
Family:   Classic zinc finger, C2H2 [ 57668] (30)


Family statistics
Genomes (54) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 138 348 3
Proteins 138 348 3


Human Phenotype (HP)

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show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0.09394Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.1123Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.326Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.03583Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.08336Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal finger phalanx morphology0.2746InformativeInherited
Phenotypic Abnormality (PA)Polydactyly0.006743Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of salivation0.1621Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.8999Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.005625Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.02921Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.5019Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.0008422InformativeDirect
Mammalian Phenotype (MP)abnormal long bone morphology0.001737InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.06583InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.007639Least InformativeInherited
Worm Phenotype (WP)body region morphology variant0.03756Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.03756Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.03778Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.038Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.0413Moderately InformativeInherited
Worm Phenotype (WP)tail morphology variant0.0001388InformativeDirect
Worm Phenotype (WP)cell number increased0.0005455InformativeDirect
Worm Phenotype (WP)multiple anchor cells0.0001448Highly InformativeDirect
Worm Phenotype (WP)lineage variant0.000488Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.0000000959InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.00001621Least InformativeDirect
Fly Anatomy (FA)segment0.00009433Least InformativeDirect
Fly Anatomy (FA)tagma0.002653Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.00551Least InformativeInherited
Fly Anatomy (FA)anatomical group0.7356Least InformativeInherited
Fly Anatomy (FA)embryo0.8593Least InformativeInherited
Fly Anatomy (FA)larva1Least InformativeInherited
Fly Anatomy (FA)somatic cell1Least InformativeInherited
Fly Anatomy (FA)adult mesothoracic segment0.00000000003917Moderately InformativeDirect
Fly Anatomy (FA)appendage0.0000005297Moderately InformativeDirect
Fly Anatomy (FA)sense organ0.3374Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.396Moderately InformativeInherited
Fly Anatomy (FA)larval tagma0.5098Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.5288Moderately InformativeInherited
Fly Anatomy (FA)head1Moderately InformativeInherited
Fly Anatomy (FA)ganglion mother cell0.5588InformativeInherited
Fly Anatomy (FA)embryonic/larval sensillum0.001891Highly InformativeInherited
Fly Anatomy (FA)embryonic/larval head sense organ0.001891Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.7688Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.8352Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.858Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.9238Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.5677Moderately InformativeInherited
Zebrafish Anatomy (ZA)diencephalon0.1381InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.574Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.5842Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.8764Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.8827Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.01703Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.1115Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.1527Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.6641Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.0006234InformativeDirect
Xenopus ANatomical entity (XAN)neuroectoderm0.0009977InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.02624InformativeInherited
Xenopus ANatomical entity (XAN)anterior neural ridge0.00001365Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.00001971Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.000027Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.0002222Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.0003227Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.0004124Highly InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.0004252Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)gastrula stage0.000006485Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Acyltransferases0.00000000002139Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.3019Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.00002338InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0.000000000004296Highly InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000003071Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 99 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a beta-beta-alpha zinc fingers domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]