SUPERFAMILY 1.75 HMM library and genome assignments server

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Erythroid transcription factor GATA-1 family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Glucocorticoid receptor-like (DNA-binding domain) [ 57715]
Superfamily:   Glucocorticoid receptor-like (DNA-binding domain) [ 57716] (18)
Family:   Erythroid transcription factor GATA-1 [ 57717]

Family statistics
Genomes (81) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 81 407 4
Proteins 81 406 4

Disease Ontology (DO)

show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)hematopoietic system disease0.008961Moderately InformativeInherited
Disease Ontology (DO)anemia0.0003483Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.01012Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.06545Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.001361Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.001459Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.1633Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.1821Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.3403Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.363Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.0007806InformativeDirect
Phenotypic Abnormality (PA)Arrhythmia0.0009644InformativeDirect
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.0119InformativeInherited
Phenotypic Abnormality (PA)Abnormal morphology of the great vessels0.01639InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve morphology0.04528InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve physiology0.05472InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac septum morphology0.05646InformativeInherited
Phenotypic Abnormality (PA)Atrial arrhythmia0.00003721Highly InformativeDirect
Phenotypic Abnormality (PA)Bicuspid aortic valve0.00004019Highly InformativeDirect
Phenotypic Abnormality (PA)Aortic valve stenosis0.00005387Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of periauricular region0.00006578Highly InformativeDirect
Phenotypic Abnormality (PA)Hypoplastic heart0.0001294Highly InformativeDirect
Phenotypic Abnormality (PA)Skin pit0.0004379Highly InformativeDirect
Phenotypic Abnormality (PA)Congenital malformation of the great arteries0.005606Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal 5th finger morphology0.01324Highly InformativeInherited
Phenotypic Abnormality (PA)Clinodactyly0.07519Highly InformativeInherited
Phenotypic Abnormality (PA)Deviation of finger0.08766Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.004738Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.006191Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.02733Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.08777Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.000208Moderately InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.0003515Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.001528Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.002824Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.004203Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.00648Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.009244Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.01248Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.01975Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.03787Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1722Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.3441Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal erythrocyte morphology0.0002098InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle wall thickness0.0002406InformativeDirect
Mammalian Phenotype (MP)abnormal systemic artery morphology0.0007725InformativeDirect
Mammalian Phenotype (MP)hemorrhage0.0009125InformativeDirect
Mammalian Phenotype (MP)abnormal heart development0.05409InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.07146InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.1242InformativeInherited
Mammalian Phenotype (MP)small liver0.00001303Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart tube morphology0.00003112Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thoracic aorta morphology0.00009077Highly InformativeDirect
Mammalian Phenotype (MP)embryonic lethality during organogenesis, complete penetrance0.0001702Highly InformativeDirect
Mammalian Phenotype (MP)abnormal visceral yolk sac morphology0.0004568Highly InformativeDirect
Mammalian Phenotype (MP)ventricular septal defect0.0005147Highly InformativeDirect
Mammalian Phenotype (MP)decreased myeloid cell number0.04446Highly InformativeInherited
Mammalian Phenotype (MP)abnormal erythrocyte cell number0.1117Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.002611Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.0467Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.0467Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.0001368Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.02792Moderately InformativeInherited
Worm Phenotype (WP)extended life span0.000000004612InformativeDirect
Worm Phenotype (WP)cell stress response variant0.00006522InformativeDirect
Worm Phenotype (WP)brood size variant0.0005406InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.0009624InformativeDirect
Worm Phenotype (WP)organism stress response variant0.03081InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.1791InformativeInherited
Worm Phenotype (WP)epithelial development variant0.000002199Highly InformativeDirect
Worm Phenotype (WP)lineage variant0.00001592Highly InformativeDirect
Worm Phenotype (WP)paraquat response variant0.00002497Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.288Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.006129Moderately InformativeInherited
Fly Phenotype (FP)lethal - all die before end of first instar larval stage0.0004346InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)anatomical cluster0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Moderately InformativeDirect
Zebrafish Anatomy (ZA)electrically active cell0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.2577Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.3074Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.3145Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.4665Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.591Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.02461Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.1951Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.2058Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.3689Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0.0000001781InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.000004139InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.00005595InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0005082InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.0009028InformativeDirect
Xenopus ANatomical entity (XAN)muscle0.1368InformativeInherited
Xenopus ANatomical entity (XAN)ventral blood island0.0000000004339Highly InformativeDirect
Xenopus ANatomical entity (XAN)lateral plate mesoderm0.000002024Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0001655Highly InformativeDirect
Xenopus ANatomical entity (XAN)archenteron0.0001688Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.001805Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 127 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Glucocorticoid receptor-like (DNA-binding domain) domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]