SUPERFAMILY 1.75 HMM library and genome assignments server

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Nuclear receptor family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Glucocorticoid receptor-like (DNA-binding domain) [ 57715]
Superfamily:   Glucocorticoid receptor-like (DNA-binding domain) [ 57716] (18)
Family:   Nuclear receptor [ 57721] (12)


Family statistics
Genomes (141) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,484 10,977 26
Proteins 3,481 10,975 26


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.02782Least InformativeInherited
Disease Ontology (DO)disease of metabolism0.000000237Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.005285Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.006763Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.007756Moderately InformativeInherited
Disease Ontology (DO)integumentary system disease0.04678Moderately InformativeInherited
Disease Ontology (DO)overnutrition0.0000001805InformativeDirect
Disease Ontology (DO)familial hyperlipidemia0.0001014InformativeDirect
Disease Ontology (DO)hypotrichosis0.0001851InformativeDirect
Disease Ontology (DO)cell type benign neoplasm0.0001928InformativeDirect
Disease Ontology (DO)physical disorder0.01014InformativeInherited
Disease Ontology (DO)breast carcinoma0.02248InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.06693InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.1134InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.3331InformativeInherited
Disease Ontology (DO)pancreas disease0.6241InformativeInherited
Disease Ontology (DO)hypospadias0.000004021Highly InformativeDirect
Disease Ontology (DO)gallbladder disease0.00004269Highly InformativeDirect
Disease Ontology (DO)rubella0.00006087Highly InformativeDirect
Disease Ontology (DO)lipid storage disease0.00008531Highly InformativeDirect
Disease Ontology (DO)uterine benign neoplasm0.0002876Highly InformativeDirect
Disease Ontology (DO)breast lobular carcinoma0.0003575Highly InformativeDirect
Disease Ontology (DO)endocrine pancreas disease0.0004603Highly InformativeDirect
Disease Ontology (DO)thyroid carcinoma0.0007795Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3665Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.983Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.002289Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.4232Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating hormone level0.0008683InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the menstrual cycle0.04313InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.731InformativeInherited
Phenotypic Abnormality (PA)Hyperpituitarism0.000104Highly InformativeDirect
Phenotypic Abnormality (PA)Primary amenorrhea0.0003622Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.000003114Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.00001785Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.00001921Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.00002717Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.00006478Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.0005638Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.004289Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.007265Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.04726Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.00000007888Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.000000578Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.000004793Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.00002145Moderately InformativeDirect
Mammalian Phenotype (MP)adipose tissue phenotype0.00402Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.006883Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.009402Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.01298Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.01558Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.02499Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.02705Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.05459Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.05486Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.06395Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.06411Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.06625Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.09975Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.1251Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1279Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.14Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2272Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2814Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.3697Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.3749Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4273Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.481Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.5767Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.5967Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.7369Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)increased sensitivity to induced morbidity/mortality0.00007233InformativeDirect
Mammalian Phenotype (MP)abnormal metabolism0.0001337InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.0003431InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0004012InformativeDirect
Mammalian Phenotype (MP)decreased litter size0.0005397InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage morphology0.001147InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.00214InformativeInherited
Mammalian Phenotype (MP)abnormal fat pad morphology0.002398InformativeInherited
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.002866InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.003641InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.004427InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.004852InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.01365InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.03772InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.05677InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.08047InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.1172InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.133InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.2096InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.2315InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.2469InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.5917InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.6094InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.6267InformativeInherited
Mammalian Phenotype (MP)abnormal testis morphology0.6387InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.8046InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.9802InformativeInherited
Mammalian Phenotype (MP)abnormal abdominal fat pad morphology0.000005027Highly InformativeDirect
Mammalian Phenotype (MP)abnormal testis weight0.00002019Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vasodilation0.0001229Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating pituitary hormone level0.0001431Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating gonadotropin level0.0002289Highly InformativeDirect
Mammalian Phenotype (MP)abnormal energy expenditure0.0002772Highly InformativeDirect
Mammalian Phenotype (MP)decreased circulating insulin-like growth factor I level0.0003064Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development0.0003293Highly InformativeDirect
Mammalian Phenotype (MP)abnormal uterus morphology0.00034Highly InformativeDirect
Mammalian Phenotype (MP)abnormal eye development0.0003928Highly InformativeDirect
Mammalian Phenotype (MP)abnormal physiological response to xenobiotic0.0004595Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating leptin level0.0005489Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cellular cholesterol metabolism0.0006546Highly InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to atherosclerosis0.0006702Highly InformativeDirect
Mammalian Phenotype (MP)narrow eye opening0.0006854Highly InformativeDirect
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.0007924Highly InformativeDirect
Mammalian Phenotype (MP)abnormal luteinizing hormone level0.0008558Highly InformativeDirect
Mammalian Phenotype (MP)abnormal optic nerve morphology0.0008751Highly InformativeDirect
Mammalian Phenotype (MP)abnormal respiratory conducting tube morphology0.004184Highly InformativeInherited
Mammalian Phenotype (MP)abnormal social/conspecific interaction0.005786Highly InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.006147Highly InformativeInherited
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.008429Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart tube morphology0.01215Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vas deferens morphology0.0129Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circadian rhythm0.01608Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus development0.02029Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical vertebrae morphology0.02407Highly InformativeInherited
Mammalian Phenotype (MP)abnormal basal ganglion morphology0.02906Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fat cell morphology0.02979Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cornea morphology0.03568Highly InformativeInherited
Mammalian Phenotype (MP)abnormal seminiferous tubule morphology0.03587Highly InformativeInherited
Mammalian Phenotype (MP)decreased bone mass0.04195Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral arch morphology0.05248Highly InformativeInherited
Mammalian Phenotype (MP)abnormal temporal bone morphology0.05924Highly InformativeInherited
Mammalian Phenotype (MP)vertebral transformation0.06024Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.07452Highly InformativeInherited
Mammalian Phenotype (MP)abnormal locomotor activation0.07978Highly InformativeInherited
Mammalian Phenotype (MP)abnormal midbrain morphology0.08801Highly InformativeInherited
Mammalian Phenotype (MP)internal hemorrhage0.09254Highly InformativeInherited
Mammalian Phenotype (MP)vertebral fusion0.1013Highly InformativeInherited
Mammalian Phenotype (MP)abnormal occipital bone morphology0.1069Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone volume0.1331Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thyroid hormone level0.1421Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.1887Highly InformativeInherited
Mammalian Phenotype (MP)abnormal middle ear morphology0.3667Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dorsal aorta morphology0.6164Highly InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.7577Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.01594Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)transgene expression reduced0.000001057InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.2147InformativeInherited
Worm Phenotype (WP)fat content variant0.8759InformativeInherited
Worm Phenotype (WP)fat content increased0.000002712Highly InformativeDirect
Worm Phenotype (WP)hatching variant0.0009706Highly InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.006647Highly InformativeInherited
Worm Phenotype (WP)social behavior variant0.02402Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.04132Least InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)segment0.002192Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.02682Least InformativeInherited
Fly Anatomy (FA)adult0.02892Least InformativeInherited
Fly Anatomy (FA)tagma0.07124Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.2426Least InformativeInherited
Fly Anatomy (FA)anatomical group0.3069Least InformativeInherited
Fly Anatomy (FA)somatic cell0.6307Least InformativeInherited
Fly Anatomy (FA)nervous system0.637Least InformativeInherited
Fly Anatomy (FA)larva0.754Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.005394Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.008285Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1073Moderately InformativeInherited
Fly Anatomy (FA)abdomen0.2563Moderately InformativeInherited
Fly Anatomy (FA)neuron0.3269Moderately InformativeInherited
Fly Anatomy (FA)larval tagma0.4352Moderately InformativeInherited
Fly Anatomy (FA)interneuron0.00006087InformativeDirect
Fly Anatomy (FA)synaptic neuropil block0.0002391InformativeDirect
Fly Anatomy (FA)segmental subdivision of organ system0.00606InformativeInherited
Fly Anatomy (FA)brain0.04436InformativeInherited
Fly Anatomy (FA)larval abdominal segment0.05302InformativeInherited
Fly Anatomy (FA)synaptic neuropil subdomain0.07392InformativeInherited
Fly Anatomy (FA)labral segment0.08636InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.1749InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.3951InformativeInherited
Fly Anatomy (FA)mushroom body intrinsic neuron0.000000523Highly InformativeDirect
Fly Anatomy (FA)mushroom body gamma-lobe0.0000009709Highly InformativeDirect
Fly Anatomy (FA)supraesophageal ganglion neuron0.000007394Highly InformativeDirect
Fly Anatomy (FA)larval neuromere0.003158Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)anatomical cluster0.1456Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.7908Least InformativeInherited
Zebrafish Anatomy (ZA)pleuroperitoneal region0.02863InformativeInherited
Zebrafish Anatomy (ZA)embryonic structure0.08117InformativeInherited
Zebrafish Anatomy (ZA)male organism0.00002285Highly InformativeDirect
Zebrafish Anatomy (ZA)female organism0.00007574Highly InformativeDirect
Zebrafish Anatomy (ZA)gonad0.00008315Highly InformativeDirect
Zebrafish Anatomy (ZA)otic vesicle0.0003745Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 127 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Glucocorticoid receptor-like (DNA-binding domain) domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]