SUPERFAMILY 1.75 HMM library and genome assignments server

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Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cysteine-rich domain [ 57888]
Superfamily:   Cysteine-rich domain [ 57889] (3)
Family:   Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) [ 57890] (6)


Family statistics
Genomes (80) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 437 1,390 5
Proteins 437 1,389 5


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.6992Moderately InformativeInherited
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)cell type cancer0.1158Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.2895Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3378Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3959Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.4171Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.07787Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.115Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.2841Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.3578Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.3671Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.5941Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.02116InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.187InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the inner ear0.2572InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.3426InformativeInherited
Phenotypic Abnormality (PA)Nephritis0.0002829Highly InformativeDirect
Phenotypic Abnormality (PA)Morphological abnormality of the inner ear0.0006175Highly InformativeDirect
Phenotypic Abnormality (PA)Spina bifida occulta0.0007331Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the hairline0.2585Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.0106Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.03859Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.1742Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.2158Least InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.002326Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic transmission0.008499Moderately InformativeInherited
Mammalian Phenotype (MP)adipose tissue phenotype0.0134Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.04601Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.1161Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.1232Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.1621Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.2934Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.3563Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.5112Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.724Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.01365InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.03076InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.5605InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.7618InformativeInherited
Mammalian Phenotype (MP)decreased thymocyte number0.000771Highly InformativeDirect
Mammalian Phenotype (MP)increased skin tumor incidence0.004002Highly InformativeInherited
Mammalian Phenotype (MP)abnormal long term potentiation0.088Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.001302Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.02151Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.2839Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.2839Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.005334Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.01511Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.03284Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.03289Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.03393Moderately InformativeInherited
Worm Phenotype (WP)protein subcellular localization variant0.000002984InformativeDirect
Worm Phenotype (WP)drug resistant0.00009688InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.0001627InformativeDirect
Worm Phenotype (WP)acetylcholinesterase inhibitor response variant0.005939InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.04996InformativeInherited
Worm Phenotype (WP)cell stress response variant0.2079InformativeInherited
Worm Phenotype (WP)drug induced gene expression variant0.000000000198Highly InformativeDirect
Worm Phenotype (WP)response to injury variant0.0000001758Highly InformativeDirect
Worm Phenotype (WP)thermotaxis variant0.000003838Highly InformativeDirect
Worm Phenotype (WP)odorant positive chemotaxis variant0.0001848Highly InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.01125Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.8426Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.00004009Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Cysteine-rich domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]