SUPERFAMILY 1.75 HMM library and genome assignments server

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Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Cysteine-rich domain [ 57888]
Superfamily:   Cysteine-rich domain [ 57889] (3)
Family:   Protein kinase cysteine-rich domain (cys2, phorbol-binding domain) [ 57890] (6)


Family statistics
Genomes (80) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 437 1,390 5
Proteins 437 1,389 5


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.6992Moderately InformativeInherited
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)cell type cancer0.1158Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.2915Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3315Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.404Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.08015Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.1191Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.3707Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.3811Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.596Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.02146InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the inner ear0.2528InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.3484InformativeInherited
Phenotypic Abnormality (PA)Nephritis0.0002969Highly InformativeDirect
Phenotypic Abnormality (PA)Morphological abnormality of the inner ear0.0006364Highly InformativeDirect
Phenotypic Abnormality (PA)Spina bifida occulta0.000802Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.01064Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.03869Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.1742Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.2157Least InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.002324Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic transmission0.008505Moderately InformativeInherited
Mammalian Phenotype (MP)adipose tissue phenotype0.01339Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.046Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.1164Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.1235Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.1618Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.2935Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.3569Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.5102Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.7248Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.01362InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.03059InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.5614InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.7619InformativeInherited
Mammalian Phenotype (MP)decreased thymocyte number0.0007655Highly InformativeDirect
Mammalian Phenotype (MP)increased skin tumor incidence0.004002Highly InformativeInherited
Mammalian Phenotype (MP)abnormal long term potentiation0.08803Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.002063Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.005601Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.01274Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.2636Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.00002907Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.007891Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.01231Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.2398Moderately InformativeInherited
Worm Phenotype (WP)drug resistant0.0001163InformativeDirect
Worm Phenotype (WP)organism temperature response variant0.0001195InformativeDirect
Worm Phenotype (WP)chemical resistant0.0008967InformativeDirect
Worm Phenotype (WP)acetylcholinesterase inhibitor response variant0.004331InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.01166InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.03514InformativeInherited
Worm Phenotype (WP)cell stress response variant0.07499InformativeInherited
Worm Phenotype (WP)chemosensory response variant0.0899InformativeInherited
Worm Phenotype (WP)drug induced gene expression variant0.0000000003463Highly InformativeDirect
Worm Phenotype (WP)thermotaxis variant0.0000001353Highly InformativeDirect
Worm Phenotype (WP)odorant positive chemotaxis variant0.0003978Highly InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.01846Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.8398Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.00003996Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Cysteine-rich domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]