SUPERFAMILY 1.75 HMM library and genome assignments server

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Leucine zipper domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Leucine zipper domain [ 57959]
Families:   Leucine zipper domain [ 57960] (16)


Superfamily statistics
Genomes (480) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 15,938 43,418 97
Proteins 15,887 43,270 97


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.006303Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.0002538Moderately InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.02594Least InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.06506Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.1069Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1077Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal liver physiology0.001322InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.1078InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.2777InformativeInherited
Mammalian Phenotype (MP)abnormal bone ossification0.3098InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.6937InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.8364InformativeInherited
Mammalian Phenotype (MP)thick epidermis0.0006907Highly InformativeDirect
Mammalian Phenotype (MP)hyperkeratosis0.005408Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.002114Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.01918Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.00007095Moderately InformativeDirect
Worm Phenotype (WP)drug response variant0.04497Moderately InformativeInherited
Worm Phenotype (WP)transgene expression reduced0.0000001025InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.005702InformativeInherited
Worm Phenotype (WP)RNA expression variant0.05078InformativeInherited
Worm Phenotype (WP)pathogen susceptibility increased0.0007844Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.0007908Least InformativeDirect
Fly Phenotype (FP)lethal0.5024Moderately InformativeInherited
Fly Phenotype (FP)lethal - all die before end of first instar larval stage0.0006467InformativeDirect
Fly Phenotype (FP)developmental rate defective0.0005997Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.2119Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.5783Least InformativeInherited
Fly Anatomy (FA)epithelium0.3004Moderately InformativeInherited
Fly Anatomy (FA)adult heart0.0007785InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval system0.08502InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.159InformativeInherited
Fly Anatomy (FA)embryonic epidermis0.03027Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.1304Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.4504Least InformativeInherited
Plant ANatomical entity (PAN)root tip0.02467InformativeInherited
Plant ANatomical entity (PAN)primary root0.0007691Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 48 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Leucine zipper domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 48 hidden Markov models representing the Leucine zipper domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]