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Tropomyosin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Tropomyosin [ 57997]
Families:   Tropomyosin [ 57998]


Superfamily statistics
Genomes (1,718) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 11,162 45,295 8
Proteins 10,221 42,225 8


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0.04129Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1205Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.1587Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.2604Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.4375Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.4913Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6773Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.0007128Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.002761Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.0472Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.04859Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.0661Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.09685Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.1698Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.3808Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.5677Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the synovia0.0009014InformativeDirect
Phenotypic Abnormality (PA)Joint dislocation0.001992InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.006838InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.009254InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.0237InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.02655InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.03469InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle fiber morphology0.04205InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.04739InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.09536InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.1014InformativeInherited
Phenotypic Abnormality (PA)Gait disturbance0.157InformativeInherited
Phenotypic Abnormality (PA)Breech presentation0.000001307Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber inclusion bodies0.00000949Highly InformativeDirect
Phenotypic Abnormality (PA)Scapular winging0.0001275Highly InformativeDirect
Phenotypic Abnormality (PA)Narrow face0.0002267Highly InformativeDirect
Phenotypic Abnormality (PA)Neck muscle weakness0.0008634Highly InformativeDirect
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.001203Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the elbow0.004342Highly InformativeInherited
Phenotypic Abnormality (PA)Cardiomyopathy0.004411Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating protein level0.005919Highly InformativeInherited
Phenotypic Abnormality (PA)Contractures of the joints of the upper limbs0.00692Highly InformativeInherited
Phenotypic Abnormality (PA)Limitation of joint mobility0.02807Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the knee0.2087Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00005154Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0005103Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.006778Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.00072Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.06912Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00007209InformativeDirect
Worm Phenotype (WP)locomotion reduced0.0001892InformativeDirect
Worm Phenotype (WP)sluggish0.00000234Highly InformativeDirect
Worm Phenotype (WP)embryonic arrest0.0005346Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0.7163Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.753Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.1821Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.525Moderately InformativeInherited
Zebrafish Anatomy (ZA)pericardial region0.1042InformativeInherited
Zebrafish Anatomy (ZA)heart0.02005Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.185Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.3434Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.6404Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.7564Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.06511Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.08255Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.3306Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.004075InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.01805InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.08927InformativeInherited
Xenopus ANatomical entity (XAN)cardiovascular system0.1172InformativeInherited
Xenopus ANatomical entity (XAN)somite0.005232Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.6668Least InformativeInherited
Xenopus DEvelopment stage (XDE)adult frog stage0.0001473Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details) Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tropomyosin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Tropomyosin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]