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Tropomyosin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Tropomyosin [ 57997]
Families:   Tropomyosin [ 57998]


Superfamily statistics
Genomes (1,718) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 11,162 45,295 8
Proteins 10,221 42,225 8


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0.04329Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1185Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.1518Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.2567Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.4283Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.4857Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6749Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.0007204Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal muscle morphology0.0007597Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the upper limb0.04415Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.05175Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.08883Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.166Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.3972Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.5612Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal tendon morphology0.003029InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the synovia0.005938InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.007179InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.0087InformativeInherited
Phenotypic Abnormality (PA)Joint dislocation0.01263InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.01809InformativeInherited
Phenotypic Abnormality (PA)Abnormality of joint mobility0.02046InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.03166InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.04651InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.05764InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle fiber morphology0.07172InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.08516InformativeInherited
Phenotypic Abnormality (PA)Gait disturbance0.1611InformativeInherited
Phenotypic Abnormality (PA)Breech presentation0.000001459Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber inclusion bodies0.00001049Highly InformativeDirect
Phenotypic Abnormality (PA)Scapular winging0.0001305Highly InformativeDirect
Phenotypic Abnormality (PA)Narrow face0.0002386Highly InformativeDirect
Phenotypic Abnormality (PA)Neck muscle weakness0.0009452Highly InformativeDirect
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.001219Highly InformativeInherited
Phenotypic Abnormality (PA)Cardiomyopathy0.004743Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating protein level0.006228Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.02202Highly InformativeInherited
Phenotypic Abnormality (PA)Limitation of joint mobility0.02776Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of upper limb joint0.07302Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the knee0.201Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00005243Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0004517Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.002929Least InformativeInherited
Worm Phenotype (WP)movement variant0.000117Moderately InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00006952InformativeDirect
Worm Phenotype (WP)locomotion reduced0.0001823InformativeDirect
Worm Phenotype (WP)sluggish0.000002258Highly InformativeDirect
Worm Phenotype (WP)embryonic arrest0.000476Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.5261Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.7562Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.1821Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.5221Moderately InformativeInherited
Zebrafish Anatomy (ZA)pericardial region0.1043InformativeInherited
Zebrafish Anatomy (ZA)heart0.02015Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.1838Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.3451Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.6363Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.7544Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.06344Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.07743Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.3249Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.003555InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.01802InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.08444InformativeInherited
Xenopus ANatomical entity (XAN)cardiovascular system0.1103InformativeInherited
Xenopus ANatomical entity (XAN)somite0.004494Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.6695Least InformativeInherited
Xenopus DEvelopment stage (XDE)adult frog stage0.0001295Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details) Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tropomyosin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Tropomyosin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]