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Tropomyosin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Tropomyosin [ 57997]
Families:   Tropomyosin [ 57998]


Superfamily statistics
Genomes (1,718) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 11,162 45,295 8
Proteins 10,221 42,225 8


Functional annotation
General category Processes_IC
Detailed category Cell motility

Document:
Function annotation of SCOP domain superfamilies

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0.04336Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1183Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.1517Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.2567Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.4271Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.4851Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6749Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.0007124Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal muscle morphology0.0007638Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the upper limb0.04396Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.05163Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.08904Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.166Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.3988Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.5617Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal tendon morphology0.003025InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the synovia0.005938InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.007174InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.00869InformativeInherited
Phenotypic Abnormality (PA)Joint dislocation0.01262InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.01802InformativeInherited
Phenotypic Abnormality (PA)Abnormality of joint mobility0.02041InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.03177InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.04648InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.05809InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle fiber morphology0.07151InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.08503InformativeInherited
Phenotypic Abnormality (PA)Gait disturbance0.1616InformativeInherited
Phenotypic Abnormality (PA)Breech presentation0.000001457Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber inclusion bodies0.00001047Highly InformativeDirect
Phenotypic Abnormality (PA)Scapular winging0.0001304Highly InformativeDirect
Phenotypic Abnormality (PA)Narrow face0.0002381Highly InformativeDirect
Phenotypic Abnormality (PA)Neck muscle weakness0.0009385Highly InformativeDirect
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.001216Highly InformativeInherited
Phenotypic Abnormality (PA)Cardiomyopathy0.004799Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating protein level0.006221Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.022Highly InformativeInherited
Phenotypic Abnormality (PA)Limitation of joint mobility0.02773Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of upper limb joint0.07311Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the knee0.2009Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.0002965Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0004392Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.002482Least InformativeInherited
Worm Phenotype (WP)movement variant0.0001137Moderately InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0000673InformativeDirect
Worm Phenotype (WP)locomotion reduced0.0001763InformativeDirect
Worm Phenotype (WP)sluggish0.000002174Highly InformativeDirect
Worm Phenotype (WP)embryonic arrest0.0004844Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0.5026Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.742Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.1836Moderately InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.4959Moderately InformativeInherited
Zebrafish Anatomy (ZA)pericardial region0.1054InformativeInherited
Zebrafish Anatomy (ZA)heart0.02061Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.183Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.3454Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.6275Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.7522Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.06138Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.0692Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.3069Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.002818InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.01732InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.07131InformativeInherited
Xenopus ANatomical entity (XAN)cardiovascular system0.1006InformativeInherited
Xenopus ANatomical entity (XAN)somite0.003579Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.6697Least InformativeInherited
Xenopus DEvelopment stage (XDE)adult frog stage0.0001297Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details) Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tropomyosin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Tropomyosin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]