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Tropomyosin family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Tropomyosin [ 57997]
Family:   Tropomyosin [ 57998]


Family statistics
Genomes (147) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 975 3,786 7
Proteins 926 3,602 7


Human Phenotype (HP)

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show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.02184Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.0295Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.129Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.2424Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.3592Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.3979Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.0004219Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.001671Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.003069Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.02896Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.03844Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.05438Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.07861Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.1901Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.3385Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.351Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hip joint0.000458InformativeDirect
Phenotypic Abnormality (PA)Joint dislocation0.001333InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating protein level0.003641InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.01781InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.01863InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.0196InformativeInherited
Phenotypic Abnormality (PA)Abnormal morphology of the great vessels0.02706InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.04153InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.07947InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.08516InformativeInherited
Phenotypic Abnormality (PA)Abnormal myocardium morphology0.1064InformativeInherited
Phenotypic Abnormality (PA)Muscle weakness0.1256InformativeInherited
Phenotypic Abnormality (PA)Breech presentation0.000001074Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber inclusion bodies0.000004315Highly InformativeDirect
Phenotypic Abnormality (PA)Scapular winging0.00009038Highly InformativeDirect
Phenotypic Abnormality (PA)Narrow face0.0001695Highly InformativeDirect
Phenotypic Abnormality (PA)Aortic aneurysm0.0003265Highly InformativeDirect
Phenotypic Abnormality (PA)Talipes equinovarus0.0004918Highly InformativeDirect
Phenotypic Abnormality (PA)Neck muscle weakness0.0005076Highly InformativeDirect
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.0007081Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the elbow0.003007Highly InformativeInherited
Phenotypic Abnormality (PA)Contractures of the joints of the upper limbs0.004494Highly InformativeInherited
Phenotypic Abnormality (PA)Limitation of joint mobility0.02235Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the knee0.2036Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.001781Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.008016Least InformativeInherited
Worm Phenotype (WP)movement variant0.04084Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.1335Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.8399Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0001298InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0001715InformativeDirect
Worm Phenotype (WP)locomotion reduced0.0004527InformativeDirect
Worm Phenotype (WP)sluggish0.000004657Highly InformativeDirect
Worm Phenotype (WP)embryonic arrest0.0009852Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)anatomical cluster0.4728Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.6799Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.7418Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.1638Moderately InformativeInherited
Zebrafish Anatomy (ZA)pericardial region0.08595InformativeInherited
Zebrafish Anatomy (ZA)heart0.01564Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.06826Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.3579Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.6041Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.7011Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.7543Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.08136Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.09126Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.2426Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.003032InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.009382InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.07112InformativeInherited
Xenopus ANatomical entity (XAN)cardiovascular system0.1051InformativeInherited
Xenopus ANatomical entity (XAN)somite0.003415Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.7598Least InformativeInherited
Xenopus DEvelopment stage (XDE)adult frog stage0.0001273Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.01804Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0.000005246Moderately InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Tropomyosin domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]