SUPERFAMILY 1.75 HMM library and genome assignments server

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SNARE fusion complex superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   SNARE fusion complex [ 58038]
Families:   SNARE fusion complex [ 58039] (11)


Superfamily statistics
Genomes (515) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 11,593 30,487 29
Proteins 10,536 27,745 29


Functional annotation
General category coiled coil
Detailed category The code refers to 4-helix bundles. These are a type of structure which frequently contain coiled-coils.

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)benign neoplasm0.0422Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.002863InformativeInherited
Disease Ontology (DO)endocrine organ benign neoplasm0.00009375Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the head0.199Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.2156Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of higher mental function0.07558Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.1091Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.3657Moderately InformativeInherited
Phenotypic Abnormality (PA)Seizures0InformativeDirect
Phenotypic Abnormality (PA)Abnormal nervous system electrophysiology0.001307InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the synovia0.00141InformativeInherited
Phenotypic Abnormality (PA)Joint dislocation0.002641InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.003525InformativeInherited
Phenotypic Abnormality (PA)Neurological speech impairment0.005108InformativeInherited
Phenotypic Abnormality (PA)Abnormality of pelvic girdle bone morphology0.007142InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.00873InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.01789InformativeInherited
Phenotypic Abnormality (PA)Abnormal reflex0.1871InformativeInherited
Phenotypic Abnormality (PA)Areflexia0.00001264Highly InformativeDirect
Phenotypic Abnormality (PA)EEG with generalized epileptiform discharges0.0001458Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased fetal movement0.0002672Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1909Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.8688Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.04961Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3801Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.4498Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.06478InformativeInherited
Mammalian Phenotype (MP)enhanced paired-pulse facilitation0.00006396Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.0003986Least InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.00373Least InformativeInherited
Fly Phenotype (FP)behavior defective0.4402Moderately InformativeInherited
Fly Phenotype (FP)neurophysiology defective0.0005633InformativeDirect
Fly Phenotype (FP)locomotor behavior defective0.1613InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell0.0000001036InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.00000189Moderately InformativeDirect

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 25 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SNARE fusion complex domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 25 hidden Markov models representing the SNARE fusion complex superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]