SUPERFAMILY 1.75 HMM library and genome assignments server

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Apolipoprotein A-I family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Apolipoprotein A-I [ 58112]
Superfamily:   Apolipoprotein A-I [ 58113]
Family:   Apolipoprotein A-I [ 58114]


Family statistics
Genomes (42) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 51 169 1
Proteins 51 169 1


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0Moderately InformativeDirect
Disease Ontology (DO)artery disease0Moderately InformativeDirect
Disease Ontology (DO)syndrome0Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.001663Moderately InformativeInherited
Disease Ontology (DO)heart disease0InformativeDirect
Disease Ontology (DO)familial hyperlipidemia0InformativeDirect
Disease Ontology (DO)atherosclerosis0InformativeDirect
Disease Ontology (DO)coronary artery disease0InformativeDirect
Disease Ontology (DO)overnutrition0InformativeDirect
Disease Ontology (DO)glucose metabolism disease1InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Localized skin lesion0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal homeostasis0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal vascular morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0InformativeDirect
Phenotypic Abnormality (PA)Atherosclerosis0Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal triglyceride level0InformativeDirect
Mammalian Phenotype (MP)abnormal cholesterol homeostasis0InformativeDirect
Mammalian Phenotype (MP)abnormal lipoprotein level0InformativeDirect
Mammalian Phenotype (MP)abnormal circulating triglyceride level0InformativeDirect
Mammalian Phenotype (MP)abnormal sterol level0InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)urinary system0InformativeDirect
Xenopus ANatomical entity (XAN)solid compound organ0InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)unspecified stage0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Apolipoprotein A-I domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Internal database links ]