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Riboflavin synthase domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Reductase/isomerase/elongation factor common domain [ 50412] (4)
Superfamily:   Riboflavin synthase domain-like [ 63380] (3)
Families:   Riboflavin synthase [ 63783]
  Ferredoxin reductase FAD-binding domain-like [ 63381] (9)
  NADPH-cytochrome p450 reductase FAD-binding domain-like [ 50438] (3)


Superfamily statistics
Genomes (3,025) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 25,880 172,269 62
Proteins 23,267 151,979 60


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.000000000000007826Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.00000000001461InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.06286InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Sulfite reductase (NADPH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADH)0Highly InformativeDirect
Enzyme Commission (EC)Nitric oxide dioxygenase0.000000000001117Highly InformativeDirect
Enzyme Commission (EC)Nitrate reductase (NADPH)0.0000000004944Highly InformativeDirect
Enzyme Commission (EC)With a oxygen as acceptor0.000000004206Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.6875Least InformativeInherited
Disease Ontology (DO)artery disease0.006925Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.01808Moderately InformativeInherited
Disease Ontology (DO)brain disease0.1507Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.2257Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.8563Moderately InformativeInherited
Disease Ontology (DO)allergic rhinitis0.00002284InformativeDirect
Disease Ontology (DO)parasitic protozoa infectious disease0.00005774InformativeDirect
Disease Ontology (DO)migraine0.0001922InformativeDirect
Disease Ontology (DO)hypertension0.0006238InformativeDirect
Disease Ontology (DO)primary immunodeficiency disease0.06464InformativeInherited
Disease Ontology (DO)phagocyte bactericidal dysfunction0.000000456Highly InformativeDirect
Disease Ontology (DO)hypothyroidism0.00003278Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.01362Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.0192Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.06751Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.2207Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.3367Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4219Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.4996Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5295Least InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.0008775Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.001742Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.002188Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.01747Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.02349Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.02574Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.05305Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.05634Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.09976Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.1232Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.1421Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.1835Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.2275Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.2625Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.2845Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.2877Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3452Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3785Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.4685Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.4751Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.4861Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.7423Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal stomach morphology0.000055InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0.000129InformativeDirect
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.0002844InformativeDirect
Mammalian Phenotype (MP)abnormal amino acid level0.0005688InformativeDirect
Mammalian Phenotype (MP)impaired muscle contractility0.000629InformativeDirect
Mammalian Phenotype (MP)abnormal lung morphology0.0007085InformativeDirect
Mammalian Phenotype (MP)abnormal bone ossification0.001253InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.001456InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule morphology0.003379InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.003641InformativeInherited
Mammalian Phenotype (MP)abnormal cholesterol level0.003944InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.005606InformativeInherited
Mammalian Phenotype (MP)abnormal renal corpuscle morphology0.007618InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.01157InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.01652InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.02054InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle contractility0.02216InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipoprotein level0.02324InformativeInherited
Mammalian Phenotype (MP)abnormal smooth muscle morphology0.02592InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.03162InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.03923InformativeInherited
Mammalian Phenotype (MP)abnormal gas homeostasis0.04034InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.04536InformativeInherited
Mammalian Phenotype (MP)abnormal phagocyte morphology0.06418InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.07167InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary hormone level0.09793InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.1016InformativeInherited
Mammalian Phenotype (MP)abnormal circulating enzyme level0.1065InformativeInherited
Mammalian Phenotype (MP)increased leukocyte cell number0.1231InformativeInherited
Mammalian Phenotype (MP)abnormal intestine physiology0.1682InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.2134InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.25InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.3495InformativeInherited
Mammalian Phenotype (MP)pyloric sphincter hypertrophy0.000000001841Highly InformativeDirect
Mammalian Phenotype (MP)glomerular capillary thrombosis0.000000009002Highly InformativeDirect
Mammalian Phenotype (MP)decreased urine sodium level0.00000001225Highly InformativeDirect
Mammalian Phenotype (MP)perivascular fibrosis0.0000000775Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nitric oxide homeostasis0.0000001162Highly InformativeDirect
Mammalian Phenotype (MP)decreased systemic arterial blood pressure0.0000001356Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality0.0000002309Highly InformativeDirect
Mammalian Phenotype (MP)increased renal tubule apoptosis0.0000007336Highly InformativeDirect
Mammalian Phenotype (MP)renal tubular necrosis0.0000007336Highly InformativeDirect
Mammalian Phenotype (MP)increased prostaglandin level0.0000007336Highly InformativeDirect
Mammalian Phenotype (MP)liver vascular congestion0.000002688Highly InformativeDirect
Mammalian Phenotype (MP)polydipsia0.000005531Highly InformativeDirect
Mammalian Phenotype (MP)pulmonary vascular congestion0.000007494Highly InformativeDirect
Mammalian Phenotype (MP)decreased adiponectin level0.000009955Highly InformativeDirect
Mammalian Phenotype (MP)increased white adipose tissue amount0.00002256Highly InformativeDirect
Mammalian Phenotype (MP)thick ventricular wall0.00002589Highly InformativeDirect
Mammalian Phenotype (MP)hypertension0.00003592Highly InformativeDirect
Mammalian Phenotype (MP)abnormal blood-brain barrier function0.00003653Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating LDL cholesterol level0.00004056Highly InformativeDirect
Mammalian Phenotype (MP)cardiac interstitial fibrosis0.00004056Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone mineralization0.00005045Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating alkaline phosphatase level0.00005045Highly InformativeDirect
Mammalian Phenotype (MP)increased systemic arterial systolic blood pressure0.00005997Highly InformativeDirect
Mammalian Phenotype (MP)increased osteoclast cell number0.00006647Highly InformativeDirect
Mammalian Phenotype (MP)cardiac hypertrophy0.00008664Highly InformativeDirect
Mammalian Phenotype (MP)glomerulosclerosis0.00009729Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart ventricle pressure0.00009798Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating creatinine level0.0001344Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating pituitary hormone level0.0002419Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart left ventricle size0.0003903Highly InformativeDirect
Mammalian Phenotype (MP)abnormal blood flow velocity0.0004929Highly InformativeDirect
Mammalian Phenotype (MP)reduced long term potentiation0.0006105Highly InformativeDirect
Mammalian Phenotype (MP)decreased heart rate0.0006105Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level0.0007994Highly InformativeDirect
Mammalian Phenotype (MP)altered response to CNS ischemic injury0.001364Highly InformativeInherited
Mammalian Phenotype (MP)increased heart ventricle size0.111Highly InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to injury0.1167Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.002938Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.008168Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.1052Moderately InformativeInherited
Worm Phenotype (WP)vesicle morphology variant0.000002648InformativeDirect
Worm Phenotype (WP)pattern protein expression variant0.0002862InformativeDirect
Worm Phenotype (WP)lysosome-related organelle morphology variant0.0001923Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)central nervous system0.3325Moderately InformativeInherited
Zebrafish Anatomy (ZA)optic tectum0.0001905InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0InformativeDirect
Enzyme Commission (EC)Catalysing the translocation of inorganic cations0InformativeDirect
Enzyme Commission (EC)Acting on a sulfur group of donors0.0000000000002559InformativeDirect
Enzyme Commission (EC)Acting on other nitrogenous compounds as donors0.00005734InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor0Highly InformativeDirect
Enzyme Commission (EC)Acting on iron-sulfur proteins as donors0Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Oxidizing metal ions0.00000000000001285Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.00002283Highly InformativeDirect
Enzyme Commission (EC)With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen0.6487Highly InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 47 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Riboflavin synthase domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 47 hidden Markov models representing the Riboflavin synthase domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]