|
|
LEM domain superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | General |
| Detailed category | Lipid/membrane binding |
Function annotation of SCOP domain superfamilies
InterPro annotation
| Cross references | IPR011015 SSF63451 Protein matches |
| Abstract | The LEM domain is a ~40-residue motif found in nuclear
membrane-associated proteins, including lamino-associated polypeptide 2
(LAP2), emerin, MAN1, otefin and Lem-3 [ 11792821]. Defects
in the emerin gene are a cause of Emery-Dreifuss muscular dystrophy, an
X-linked disorder characterised by early contractures, muscle wasting,
weakness and cardiomyopathy. The N-terminal LEM domain in emerin mediates
binding to BAF (barrier-to-autointegration factor). |
InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
|
Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
|
Alignments of sequences to 3 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
|
|
Browse and view proteins in genomes which have
different domain combinations including a LEM domain domain.
|
Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
|
|
Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
|
There are 3 hidden Markov models representing the LEM domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
|
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]
|
0
