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Frizzled cysteine-rich domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Frizzled cysteine-rich domain [ 63500]
Superfamily:   Frizzled cysteine-rich domain [ 63501]
Families:   Frizzled cysteine-rich domain [ 63502] (2)


Superfamily statistics
Genomes (180) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,267 6,209 2
Proteins 2,126 5,769 2


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.07348Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.009234Moderately InformativeInherited
Disease Ontology (DO)myeloid neoplasm0.0002053InformativeDirect
Disease Ontology (DO)multiple myeloma0.00001925Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0005289Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.01235Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.09357Least InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.0006947Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.004808Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.04468Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.1932Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2706Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3627Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.00004749InformativeDirect
Mammalian Phenotype (MP)abnormal neural tube morphology0.005856InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.03817InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.04466InformativeInherited
Mammalian Phenotype (MP)abnormal embryo development0.4199InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.6044InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube closure0.00000007672Highly InformativeDirect
Mammalian Phenotype (MP)fused somites0.000002312Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cochlear outer hair cell morphology0.00001588Highly InformativeDirect
Mammalian Phenotype (MP)decreased somite size0.0000434Highly InformativeDirect
Mammalian Phenotype (MP)incomplete somite formation0.0001674Highly InformativeDirect
Mammalian Phenotype (MP)abnormal coat/hair pigmentation0.04741Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell stereociliary bundle morphology0.1058Highly InformativeInherited
Mammalian Phenotype (MP)abnormal gastrulation0.4164Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0007502Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.002936Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.00294Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.01183Least InformativeInherited
Worm Phenotype (WP)locomotion variant0Moderately InformativeDirect
Worm Phenotype (WP)movement variant0Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.00003767Moderately InformativeDirect
Worm Phenotype (WP)neuron development variant0.000638Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.00438Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.00438Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.00439Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.0044Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.004691Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.0145Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.02774Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.1699Moderately InformativeInherited
Worm Phenotype (WP)neuron migration variant0InformativeDirect
Worm Phenotype (WP)male morphology variant0.000001615InformativeDirect
Worm Phenotype (WP)cell number increased0.00001604InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.00003405InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.0005275InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.09814InformativeInherited
Worm Phenotype (WP)neuropil development variant0Highly InformativeDirect
Worm Phenotype (WP)anterior neuron migration defective0Highly InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.0000000000001708Highly InformativeDirect
Worm Phenotype (WP)cell division polarity variant0.00000000008471Highly InformativeDirect
Worm Phenotype (WP)multiple anchor cells0.00000003657Highly InformativeDirect
Worm Phenotype (WP)epithelial development variant0.00000006066Highly InformativeDirect
Worm Phenotype (WP)cell polarity variant0.0000001243Highly InformativeDirect
Worm Phenotype (WP)cell number decreased0.0000008777Highly InformativeDirect
Worm Phenotype (WP)antibody staining variant0.000001652Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)head0Moderately InformativeDirect
Fly Anatomy (FA)thorax0Moderately InformativeDirect
Fly Anatomy (FA)embryo0Moderately InformativeDirect
Fly Anatomy (FA)adult segment0Moderately InformativeDirect
Fly Anatomy (FA)gonad0Moderately InformativeDirect
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0Moderately InformativeDirect
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)epithelium0Moderately InformativeDirect
Fly Anatomy (FA)region of integument0Moderately InformativeDirect
Fly Anatomy (FA)sensory system0Moderately InformativeDirect
Fly Anatomy (FA)epithelial cell0InformativeDirect
Fly Anatomy (FA)adult procephalic segment0InformativeDirect
Fly Anatomy (FA)leg0InformativeDirect
Fly Anatomy (FA)germline cyst0InformativeDirect
Fly Anatomy (FA)ovariole0InformativeDirect
Fly Anatomy (FA)chaeta0InformativeDirect
Fly Anatomy (FA)eye photoreceptor cell0InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval system0InformativeDirect
Fly Anatomy (FA)mechanosensory system0InformativeDirect
Fly Anatomy (FA)imaginal disc0Highly InformativeDirect
Fly Anatomy (FA)follicle cell0Highly InformativeDirect
Fly Anatomy (FA)mechanosensory chaeta0Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.6749Least InformativeInherited
Zebrafish Anatomy (ZA)stromal cell0.0002261Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.01446Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.06449Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.3587Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.0000002642Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.000000306Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.00000105Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.002308Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.02089Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.03595Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.2188Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neural plate0.00000000003985InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0000000000616InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00000003044InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.00000004531InformativeDirect
Xenopus ANatomical entity (XAN)eye0.000006875InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.000007454InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.00002427InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.00003869InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0001573InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.000427InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.001169InformativeInherited
Xenopus ANatomical entity (XAN)cranial placode0.00302InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.03118InformativeInherited
Xenopus ANatomical entity (XAN)urinary system0.2174InformativeInherited
Xenopus ANatomical entity (XAN)tail0.3556InformativeInherited
Xenopus ANatomical entity (XAN)intestine1InformativeInherited
Xenopus ANatomical entity (XAN)otic vesicle0.0000000003037Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.0000000233Highly InformativeDirect
Xenopus ANatomical entity (XAN)axial mesoderm0.0000002966Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0000004618Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field0.000001557Highly InformativeDirect
Xenopus ANatomical entity (XAN)anatomical line0.00001426Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.00001809Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail tip0.00003331Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.00006171Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.0001336Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0001728Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.0001864Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.0002409Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.0002744Highly InformativeDirect
Xenopus ANatomical entity (XAN)presomitic mesoderm0.0005212Highly InformativeDirect

Document: XA annotation of SCOP domains

InterPro annotation
Cross references IPR000024 SSF63501 Protein matches
Abstract The Frizzled CRD (cysteine rich domain) is conserved in diverse proteins including several receptor tyrosine kinases [PubMed9637908, PubMed9684897, PubMed9852758]. In Drosophila melanogaster, members of the Frizzled family of tissue-polarity genes encode proteins that appear to function as cell-surface receptors for Wnts. The Frizzled genes belong to the seven transmembrane class of receptors (7TMR) and have in their extracellular region a cysteine-rich domain that has been implicated as the Wnt binding domain. Sequence similarity between the cysteine-rich domain of Frizzled and several receptor tyrosine kinases, which have roles in development include the muscle-specific receptor tyrosine kinase (MuSK), the neuronal specific kinase (NSK2), and ROR1 and ROR2. The structure of this domain is known and is composed mainly of alpha helices. This domain contains ten conserved cysteines that form five disulphide bridges. These are shown in schematic form below:
        +--------------+
        |              |
--C--C--C--C--C--C--C--C--C--C--
  |  |     |  |  |  |     |  |
  |  +-----+  |  |  +-----+  |
  +-----------+  +-----------+

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Frizzled cysteine-rich domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Frizzled cysteine-rich domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]