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Frizzled cysteine-rich domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Frizzled cysteine-rich domain [ 63500]
Superfamily:   Frizzled cysteine-rich domain [ 63501]
Family:   Frizzled cysteine-rich domain [ 63502] (2)


Family statistics
Genomes (143) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,243 3,133 2
Proteins 1,242 3,103 2


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.06379Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.007722Moderately InformativeInherited
Disease Ontology (DO)myeloid neoplasm0.000163InformativeDirect
Disease Ontology (DO)myeloid leukemia0.0009999InformativeDirect
Disease Ontology (DO)multiple myeloma0.00001376Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0004271Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.01029Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.08285Least InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.0001476Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.0008397Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.003339Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.03388Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.08849Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.3157Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.3438Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.4176Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.00002434InformativeDirect
Mammalian Phenotype (MP)abnormal neural tube morphology0.003593InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic growth/weight/body size0.003968InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.02358InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.03014InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube closure0.00000005628Highly InformativeDirect
Mammalian Phenotype (MP)abnormal orientation of cochlear hair cell stereociliary bundles0.000001184Highly InformativeDirect
Mammalian Phenotype (MP)pigmentation phenotype0.000401Highly InformativeDirect
Mammalian Phenotype (MP)impaired somite development0.001171Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vitelline vasculature morphology0.004579Highly InformativeInherited
Mammalian Phenotype (MP)abnormal visceral yolk sac morphology0.05283Highly InformativeInherited
Mammalian Phenotype (MP)abnormal gastrulation0.4019Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.005166Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.005166Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.02122Least InformativeInherited
Worm Phenotype (WP)organ system development variant0Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0Moderately InformativeDirect
Worm Phenotype (WP)movement variant0Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.00006889Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.00708Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.00708Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.007101Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.007121Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.007462Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.01311Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.1567Moderately InformativeInherited
Worm Phenotype (WP)neuron migration variant0InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.00000005121InformativeDirect
Worm Phenotype (WP)male morphology variant0.000002666InformativeDirect
Worm Phenotype (WP)cell number increased0.00002438InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.0008653InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.0249InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.08817InformativeInherited
Worm Phenotype (WP)nervous system development variant0Highly InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.0000000000005789Highly InformativeDirect
Worm Phenotype (WP)multiple anchor cells0.00000004319Highly InformativeDirect
Worm Phenotype (WP)epithelial development variant0.0000000923Highly InformativeDirect
Worm Phenotype (WP)cell polarity variant0.0000001438Highly InformativeDirect
Worm Phenotype (WP)cell number decreased0.000001375Highly InformativeDirect
Worm Phenotype (WP)antibody staining variant0.000002396Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)adult head0Moderately InformativeDirect
Fly Anatomy (FA)adult mesothoracic segment0Moderately InformativeDirect
Fly Anatomy (FA)gonad0Moderately InformativeDirect
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)sense organ0Moderately InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0Moderately InformativeDirect
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)epithelium0Moderately InformativeDirect
Fly Anatomy (FA)female organism0Moderately InformativeDirect
Fly Anatomy (FA)cell cluster organ0Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0Moderately InformativeDirect
Fly Anatomy (FA)epithelial cell0InformativeDirect
Fly Anatomy (FA)imaginal disc0InformativeDirect
Fly Anatomy (FA)adult procephalic segment0InformativeDirect
Fly Anatomy (FA)adult optic lobe neuron0InformativeDirect
Fly Anatomy (FA)photoreceptor cell0InformativeDirect
Fly Anatomy (FA)eye0InformativeDirect
Fly Anatomy (FA)leg0InformativeDirect
Fly Anatomy (FA)sensory organ cell0InformativeDirect
Fly Anatomy (FA)chaeta0InformativeDirect
Fly Anatomy (FA)adult peripheral nervous system0InformativeDirect
Fly Anatomy (FA)somatic cell of ovariole0InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval system0InformativeDirect
Fly Anatomy (FA)female germline cyst0InformativeDirect
Fly Anatomy (FA)adult head sensillum0InformativeDirect
Fly Anatomy (FA)histaminergic neuron0InformativeDirect
Fly Anatomy (FA)mechanosensory system0InformativeDirect
Fly Anatomy (FA)follicle cell0Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.6541Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.04571Moderately InformativeInherited
Zebrafish Anatomy (ZA)mesenchyme0.00098Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.01423Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.01507Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.05634Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.371Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.9332Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system1Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.0000005103Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.0000005909Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.000001441Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.002271Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.01911Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.04239Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.2159Moderately InformativeInherited
Xenopus ANatomical entity (XAN)tail region0.4764Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.9895Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.0000000001404InformativeDirect
Xenopus ANatomical entity (XAN)neuroectoderm0.000000009031InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00000005602InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.00000006929InformativeDirect
Xenopus ANatomical entity (XAN)eye0.000009376InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.00001239InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.00004553InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.0002438InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.0006052InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.00112InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.03243InformativeInherited
Xenopus ANatomical entity (XAN)urinary system0.2069InformativeInherited
Xenopus ANatomical entity (XAN)tail0.3635InformativeInherited
Xenopus ANatomical entity (XAN)liver and biliary system0.7025InformativeInherited
Xenopus ANatomical entity (XAN)primordium0.00000003289Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.000000687Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field0.000001675Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.00002224Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.00008462Highly InformativeDirect
Xenopus ANatomical entity (XAN)neurogenic placode0.00009556Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.0001753Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.000187Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0002044Highly InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0002334Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.0002547Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.0003111Highly InformativeDirect
Xenopus ANatomical entity (XAN)presomitic mesoderm0.0005212Highly InformativeDirect
Xenopus ANatomical entity (XAN)fin0.002985Highly InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Frizzled cysteine-rich domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]