SUPERFAMILY 1.75 HMM library and genome assignments server

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YWTD domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   6-bladed beta-propeller [ 50938] (11)
Superfamily:   YWTD domain [ 63825]
Families:   YWTD domain [ 63826] (2)


Superfamily statistics
Genomes (969) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 8,598 38,459 3
Proteins 4,662 25,238 3


Functional annotation
General category Metabolism
Detailed category Lipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.2681Least InformativeInherited
Disease Ontology (DO)artery disease0.00009003Moderately InformativeDirect
Disease Ontology (DO)neurodegenerative disease0.01836Moderately InformativeInherited
Disease Ontology (DO)Alzheimer's disease0.0005198Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.01318Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.0817Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1124Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5381Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.007398Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.0107Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.06918Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.07607Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.1185Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.2363Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.3945Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.000595InformativeDirect
Mammalian Phenotype (MP)abnormal cerebellum morphology0.0007737InformativeDirect
Mammalian Phenotype (MP)abnormal systemic artery morphology0.0009349InformativeDirect
Mammalian Phenotype (MP)abnormal circulating lipid level0.02053InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.1919InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.2738InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.4824InformativeInherited
Mammalian Phenotype (MP)abnormal cholesterol level0.908InformativeInherited
Mammalian Phenotype (MP)amyloid beta deposits0.00005087Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating triglyceride level0.0001336Highly InformativeDirect
Mammalian Phenotype (MP)abnormal liver triglyceride level0.004287Highly InformativeInherited
Mammalian Phenotype (MP)abnormal energy expenditure0.00459Highly InformativeInherited
Mammalian Phenotype (MP)abnormal digit morphology0.01Highly InformativeInherited
Mammalian Phenotype (MP)abnormal susceptibility to weight gain0.01731Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb long bone morphology0.02473Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fat pad morphology0.05056Highly InformativeInherited
Mammalian Phenotype (MP)decreased triglyceride level0.2762Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.03107Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.03111Least InformativeInherited
Worm Phenotype (WP)cell secretion variant0.0001714Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.00001833Least InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a YWTD domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the YWTD domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]