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Intermediate filament protein, coiled coil region superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Intermediate filament protein, coiled coil region [ 64593]
Families:   Intermediate filament protein, coiled coil region [ 64594] (2)


Superfamily statistics
Genomes (160) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 10,439 24,274 4
Proteins 5,423 12,807 4


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4412Least InformativeInherited
Disease Ontology (DO)cell type cancer0.06984Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.1066Moderately InformativeInherited
Disease Ontology (DO)skin disease0.6969Moderately InformativeInherited
Disease Ontology (DO)autosomal dominant disease0.05608InformativeInherited
Disease Ontology (DO)respiratory system cancer0.06516InformativeInherited
Disease Ontology (DO)carcinoma0.128InformativeInherited
Disease Ontology (DO)pulmonary large cell neuroendocrine carcinoma0.000000002344Highly InformativeDirect
Disease Ontology (DO)neuroendocrine carcinoma0.0000001139Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0000000002954Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0.02344Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.361Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.3943Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.5967Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.8397Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.009897Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.04766Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.2124Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.2609Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.2849Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye morphology0.6363Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.7378Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palm0.0004329InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness0.0006301InformativeDirect
Phenotypic Abnormality (PA)Abnormal oral mucosa morphology0.008489InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.01079InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.04023InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.4607InformativeInherited
Phenotypic Abnormality (PA)Abnormal hair morphology0.5435InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.7621InformativeInherited
Phenotypic Abnormality (PA)Epidermal thickening0.000000001953Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the plantar skin of foot0.00000003287Highly InformativeDirect
Phenotypic Abnormality (PA)Slow-growing hair0.000001401Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal blistering of the skin0.000002544Highly InformativeDirect
Phenotypic Abnormality (PA)Skin plaque0.000004254Highly InformativeDirect
Phenotypic Abnormality (PA)Corneal dystrophy0.000007152Highly InformativeDirect
Phenotypic Abnormality (PA)Hypohidrosis or hyperhidrosis0.00001142Highly InformativeDirect
Phenotypic Abnormality (PA)Nail dystrophy0.00003018Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skin0.001437Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skin of the palm0.03047Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal larynx morphology0.4144Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin pigmentation0.8831Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.3645Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.7146Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8785Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.000007114Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.005058Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.0296Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.07892Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.5651Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.8039Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.0002456InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.001125InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.255InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.3563InformativeInherited
Mammalian Phenotype (MP)abnormal fluid regulation0.424InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.7068InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.9512InformativeInherited
Mammalian Phenotype (MP)hyperkeratosis0.000001915Highly InformativeDirect
Mammalian Phenotype (MP)abnormal holocrine gland morphology0.000008199Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tongue morphology0.0000131Highly InformativeDirect
Mammalian Phenotype (MP)abnormal esophagus morphology0.00006441Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal nerve morphology0.0002438Highly InformativeDirect
Mammalian Phenotype (MP)impaired skin barrier function0.0006485Highly InformativeDirect
Mammalian Phenotype (MP)increased skin tumor incidence0.1585Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epidermis stratum spinosum morphology0.3249Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.0002965Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.002504Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.003513Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.01088Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.01446Least InformativeInherited
Worm Phenotype (WP)larval development variant0.5272Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.0000009513Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0001384Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.01249Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.1338Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.6482Moderately InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0.00001074InformativeDirect
Worm Phenotype (WP)body width variant0.00001235InformativeDirect
Worm Phenotype (WP)locomotion reduced0.002475InformativeInherited
Worm Phenotype (WP)antibody staining variant0.000000000004548Highly InformativeDirect
Worm Phenotype (WP)somatic cell death variant0.000000001796Highly InformativeDirect
Worm Phenotype (WP)muscle attachment variant0.00000008307Highly InformativeDirect
Worm Phenotype (WP)cell corpse number decreased0.0000001737Highly InformativeDirect
Worm Phenotype (WP)paralyzed0.00001764Highly InformativeDirect
Worm Phenotype (WP)molt variant0.0001673Highly InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.4314Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.6082Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.7789Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00001276Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.04444Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.2284Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.7195Moderately InformativeInherited
Xenopus ANatomical entity (XAN)peripheral nervous system0.000001118InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.00000298InformativeDirect
Xenopus ANatomical entity (XAN)tail0.00009057InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0002272InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.0006602InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.00399InformativeInherited
Xenopus ANatomical entity (XAN)hindbrain0.04479InformativeInherited
Xenopus ANatomical entity (XAN)eye0.0751InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system1InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve0.00000001414Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural nucleus0.00000005674Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0000004767Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.000001322Highly InformativeDirect
Xenopus ANatomical entity (XAN)ventricular zone0.0005931Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal neural layer0.000625Highly InformativeDirect
Xenopus ANatomical entity (XAN)proliferative region0.000764Highly InformativeDirect
Xenopus ANatomical entity (XAN)gustatory system0.0008164Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.1621Highly InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Intermediate filament protein, coiled coil region domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Intermediate filament protein, coiled coil region superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]