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Intermediate filament protein, coiled coil region superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Intermediate filament protein, coiled coil region [ 64593]
Families:   Intermediate filament protein, coiled coil region [ 64594] (2)


Superfamily statistics
Genomes (160) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 10,439 24,274 4
Proteins 5,423 12,807 4


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4422Least InformativeInherited
Disease Ontology (DO)cell type cancer0.06978Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.1066Moderately InformativeInherited
Disease Ontology (DO)skin disease0.6968Moderately InformativeInherited
Disease Ontology (DO)autosomal dominant disease0.0561InformativeInherited
Disease Ontology (DO)respiratory system cancer0.06571InformativeInherited
Disease Ontology (DO)carcinoma0.128InformativeInherited
Disease Ontology (DO)pulmonary large cell neuroendocrine carcinoma0.000000002344Highly InformativeDirect
Disease Ontology (DO)neuroendocrine carcinoma0.0000001139Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.00000000002466Least InformativeDirect
Mode of Inheritance (MI)Heterogeneous0.0006009InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0.01937Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.3697Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.3852Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.6201Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.7864Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.8441Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.008512Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.02953Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.04885Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.239Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.2755Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.2846Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.6173Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.7703Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.8396Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.9456Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.9757Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palm0.0003829InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness0.0007118InformativeDirect
Phenotypic Abnormality (PA)Regional abnormality of skin0.0106InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.04312InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.2075InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.4605InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.7872InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.8685InformativeInherited
Phenotypic Abnormality (PA)Neurological speech impairment0.9647InformativeInherited
Phenotypic Abnormality (PA)Epidermal thickening0.000000001203Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the plantar skin of foot0.00000002982Highly InformativeDirect
Phenotypic Abnormality (PA)Slow-growing hair0.00000113Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal blistering of the skin0.000002111Highly InformativeDirect
Phenotypic Abnormality (PA)Skin plaque0.000005522Highly InformativeDirect
Phenotypic Abnormality (PA)Hypohidrosis or hyperhidrosis0.000008804Highly InformativeDirect
Phenotypic Abnormality (PA)Nail dystrophy0.00002448Highly InformativeDirect
Phenotypic Abnormality (PA)Corneal dystrophy0.00009535Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skin0.001284Highly InformativeInherited
Phenotypic Abnormality (PA)Paralysis0.02735Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skin of the palm0.0316Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal larynx morphology0.4093Highly InformativeInherited
Phenotypic Abnormality (PA)Dysarthria0.5075Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin pigmentation0.8788Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.3645Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.7144Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8777Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.000007105Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.005048Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.02961Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.07893Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.565Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.8035Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.0002456InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.001121InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.255InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.3564InformativeInherited
Mammalian Phenotype (MP)abnormal fluid regulation0.4241InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.7067InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.9509InformativeInherited
Mammalian Phenotype (MP)hyperkeratosis0.00000192Highly InformativeDirect
Mammalian Phenotype (MP)abnormal holocrine gland morphology0.00000816Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tongue morphology0.00001309Highly InformativeDirect
Mammalian Phenotype (MP)abnormal esophagus morphology0.00006442Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal nerve morphology0.0002438Highly InformativeDirect
Mammalian Phenotype (MP)impaired skin barrier function0.0006463Highly InformativeDirect
Mammalian Phenotype (MP)increased skin tumor incidence0.1584Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epidermis stratum spinosum morphology0.3249Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.0005953Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.003705Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.003715Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.003961Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.0128Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.03219Least InformativeInherited
Worm Phenotype (WP)larval development variant0.5262Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.000001102Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.00005198Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.00005198Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.00005226Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.00005255Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0.00005983Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.01288Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.1244Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.2266Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.6325Moderately InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0.00001137InformativeDirect
Worm Phenotype (WP)locomotion reduced0.002603InformativeInherited
Worm Phenotype (WP)antibody staining variant0.000000000005639Highly InformativeDirect
Worm Phenotype (WP)somatic cell death variant0.000000001908Highly InformativeDirect
Worm Phenotype (WP)muscle attachment variant0.00000008818Highly InformativeDirect
Worm Phenotype (WP)cell corpse number decreased0.0000001646Highly InformativeDirect
Worm Phenotype (WP)paralyzed0.0000187Highly InformativeDirect
Worm Phenotype (WP)molt variant0.0001802Highly InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.3972Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.5746Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.8924Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.000008503Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.02869Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.1942Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.6692Moderately InformativeInherited
Xenopus ANatomical entity (XAN)dermal system0.0000009947InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.000002204InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0001541InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.0002147InformativeDirect
Xenopus ANatomical entity (XAN)tail0.0002227InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.007427InformativeInherited
Xenopus ANatomical entity (XAN)eye0.04714InformativeInherited
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0000000029Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial nerve0.00000002668Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural nucleus0.00000007894Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0000006381Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.000002498Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal inner nuclear layer0.0002259Highly InformativeDirect
Xenopus ANatomical entity (XAN)ventricular zone0.0007035Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.09366Highly InformativeInherited
Xenopus ANatomical entity (XAN)midbrain0.2641Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.05088Least InformativeInherited
Xenopus DEvelopment stage (XDE)adult frog stage0.000003333Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Intermediate filament protein, coiled coil region domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Intermediate filament protein, coiled coil region superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]