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Intermediate filament protein, coiled coil region superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Intermediate filament protein, coiled coil region [ 64593]
Families:   Intermediate filament protein, coiled coil region [ 64594] (2)


Superfamily statistics
Genomes (160) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 10,439 24,274 4
Proteins 5,423 12,807 4


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4422Least InformativeInherited
Disease Ontology (DO)cell type cancer0.06978Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.1066Moderately InformativeInherited
Disease Ontology (DO)skin disease0.6968Moderately InformativeInherited
Disease Ontology (DO)autosomal dominant disease0.0561InformativeInherited
Disease Ontology (DO)respiratory system cancer0.06571InformativeInherited
Disease Ontology (DO)carcinoma0.128InformativeInherited
Disease Ontology (DO)pulmonary large cell neuroendocrine carcinoma0.000000002344Highly InformativeDirect
Disease Ontology (DO)neuroendocrine carcinoma0.0000001139Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.0000000002913Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0.02352Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.3617Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.3951Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.5972Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.8397Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.01002Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.04707Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.2139Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.2613Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.2842Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye morphology0.6363Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.7398Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palm0.0004341InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness0.0006324InformativeDirect
Phenotypic Abnormality (PA)Abnormal oral mucosa morphology0.008495InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.01075InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.04028InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.462InformativeInherited
Phenotypic Abnormality (PA)Abnormal hair morphology0.5429InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.7623InformativeInherited
Phenotypic Abnormality (PA)Epidermal thickening0.000000001963Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the plantar skin of foot0.00000003322Highly InformativeDirect
Phenotypic Abnormality (PA)Slow-growing hair0.000001404Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal blistering of the skin0.000002527Highly InformativeDirect
Phenotypic Abnormality (PA)Skin plaque0.000004213Highly InformativeDirect
Phenotypic Abnormality (PA)Corneal dystrophy0.00000717Highly InformativeDirect
Phenotypic Abnormality (PA)Hypohidrosis or hyperhidrosis0.00001146Highly InformativeDirect
Phenotypic Abnormality (PA)Nail dystrophy0.00003019Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skin0.001433Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skin of the palm0.03044Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal larynx morphology0.4143Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin pigmentation0.8827Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.3644Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.7137Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8781Least InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.000007142Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.005061Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.02965Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.07856Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.5653Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.8037Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.0002462InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.001122InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.255InformativeInherited
Mammalian Phenotype (MP)abnormal limb morphology0.3564InformativeInherited
Mammalian Phenotype (MP)abnormal fluid regulation0.4244InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.7066InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.951InformativeInherited
Mammalian Phenotype (MP)hyperkeratosis0.000001924Highly InformativeDirect
Mammalian Phenotype (MP)abnormal holocrine gland morphology0.000008191Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tongue morphology0.00001311Highly InformativeDirect
Mammalian Phenotype (MP)abnormal esophagus morphology0.00006444Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal nerve morphology0.0002454Highly InformativeDirect
Mammalian Phenotype (MP)impaired skin barrier function0.0006479Highly InformativeDirect
Mammalian Phenotype (MP)increased skin tumor incidence0.1585Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epidermis stratum spinosum morphology0.3248Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.0006032Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.003301Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.00331Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.003588Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.01178Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.01643Least InformativeInherited
Worm Phenotype (WP)larval development variant0.523Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.000001002Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0001876Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0001876Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0001886Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.0001896Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0.0002163Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.01268Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.1184Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.643Moderately InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0.00001112InformativeDirect
Worm Phenotype (WP)locomotion reduced0.00253InformativeInherited
Worm Phenotype (WP)antibody staining variant0.000000000005224Highly InformativeDirect
Worm Phenotype (WP)somatic cell death variant0.000000001867Highly InformativeDirect
Worm Phenotype (WP)muscle attachment variant0.00000008624Highly InformativeDirect
Worm Phenotype (WP)cell corpse number decreased0.0000001803Highly InformativeDirect
Worm Phenotype (WP)paralyzed0.00001823Highly InformativeDirect
Worm Phenotype (WP)molt variant0.0001728Highly InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.4446Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.6137Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.781Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00001775Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.02119Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.2373Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.5813Moderately InformativeInherited
Xenopus ANatomical entity (XAN)peripheral nervous system0.000001539InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.000003429InformativeDirect
Xenopus ANatomical entity (XAN)tail0.000108InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0003217InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.0009029InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.005448InformativeInherited
Xenopus ANatomical entity (XAN)eye0.03732InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system1InformativeInherited
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.000000002344Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial nerve0.00000002032Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural nucleus0.00000005745Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0000005029Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.000001723Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal inner nuclear layer0.0001894Highly InformativeDirect
Xenopus ANatomical entity (XAN)ventricular zone0.0006769Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.07192Highly InformativeInherited
Xenopus ANatomical entity (XAN)midbrain0.2223Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.06211Least InformativeInherited
Xenopus DEvelopment stage (XDE)adult frog stage0.00005652Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Intermediate filament protein, coiled coil region domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Intermediate filament protein, coiled coil region superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]