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Intermediate filament protein, coiled coil region family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Intermediate filament protein, coiled coil region [ 64593]
Family:   Intermediate filament protein, coiled coil region [ 64594] (2)


Family statistics
Genomes (68) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 797 1,949 3
Proteins 797 1,947 3


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.437Least InformativeInherited
Disease Ontology (DO)integumentary system disease0.000003652Moderately InformativeDirect
Disease Ontology (DO)cell type cancer0.06599Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.0938Moderately InformativeInherited
Disease Ontology (DO)lung carcinoma0.0451InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.00000000006229Least InformativeDirect
Mode of Inheritance (MI)Heterogeneous0.0006988InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0.01535Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.2469Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.334Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.5548Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.7779Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.8046Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.9608Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.01939Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.03306Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.1868Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.2446Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.2678Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.454Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.5794Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.762Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.805Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.9383Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.9555Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Epidermal thickening0.0000000006267InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the palm0.0001709InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness0.0004334InformativeDirect
Phenotypic Abnormality (PA)Regional abnormality of skin0.005625InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.01912InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.03189InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.187InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.7502InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.8607InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin pigmentation0.8672InformativeInherited
Phenotypic Abnormality (PA)Neurological speech impairment0.9413InformativeInherited
Phenotypic Abnormality (PA)Slow-growing hair0.0000009166Highly InformativeDirect
Phenotypic Abnormality (PA)Skin plaque0.0000015Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal blistering of the skin0.000001809Highly InformativeDirect
Phenotypic Abnormality (PA)Hypohidrosis or hyperhidrosis0.000003996Highly InformativeDirect
Phenotypic Abnormality (PA)Palmar hyperkeratosis0.000008171Highly InformativeDirect
Phenotypic Abnormality (PA)Corneal dystrophy0.00002625Highly InformativeDirect
Phenotypic Abnormality (PA)Squamous cell carcinoma of the skin0.0002335Highly InformativeDirect
Phenotypic Abnormality (PA)Plantar hyperkeratosis0.000561Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the nail0.0007055Highly InformativeDirect
Phenotypic Abnormality (PA)Paralysis0.02075Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal larynx morphology0.3925Highly InformativeInherited
Phenotypic Abnormality (PA)Dysarthria0.4571Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of esophagus physiology0.5478Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.3613Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.723Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.8718Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8829Least InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.0002018Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.004457Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.02877Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.04317Moderately InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.141Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.1831Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.574Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.001105InformativeInherited
Mammalian Phenotype (MP)abnormal autopod morphology0.007042InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.04051InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.236InformativeInherited
Mammalian Phenotype (MP)abnormal mouth morphology0.3946InformativeInherited
Mammalian Phenotype (MP)abnormal fluid regulation0.425InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.7073InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.9202InformativeInherited
Mammalian Phenotype (MP)abnormal spinal nerve morphology0.00013Highly InformativeDirect
Mammalian Phenotype (MP)impaired skin barrier function0.0004813Highly InformativeDirect
Mammalian Phenotype (MP)blistering0.0008164Highly InformativeDirect
Mammalian Phenotype (MP)increased skin tumor incidence0.1275Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00151Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.009003Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.009003Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.03206Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.06555Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.000003716Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0001619Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0001619Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0001629Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.0001639Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0.0001803Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.0008654Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.1124Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.2082Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.2218Moderately InformativeInherited
Worm Phenotype (WP)locomotion reduced0.004614InformativeInherited
Worm Phenotype (WP)antibody staining variant0.0000000000159Highly InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.00001917Highly InformativeDirect
Worm Phenotype (WP)paralyzed0.00003029Highly InformativeDirect
Worm Phenotype (WP)molt variant0.0002717Highly InformativeDirect
Worm Phenotype (WP)muscle system development variant0.0005245Highly InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.4102Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.5337Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.6045Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.8727Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.8964Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00002213Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.03639Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.1994Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.6556Moderately InformativeInherited
Xenopus ANatomical entity (XAN)dermal system0.000001236InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.00000304InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0001992InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.0002695InformativeDirect
Xenopus ANatomical entity (XAN)tail0.0002927InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.01007InformativeInherited
Xenopus ANatomical entity (XAN)eye0.05451InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system1InformativeInherited
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.000000004229Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial nerve0.00000004062Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.000000974Highly InformativeDirect
Xenopus ANatomical entity (XAN)epidermis0.000001443Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.000002791Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal inner nuclear layer0.0002065Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.1022Highly InformativeInherited
Xenopus ANatomical entity (XAN)midbrain0.2819Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.05211Least InformativeInherited
Xenopus DEvelopment stage (XDE)adult frog stage0.000004113Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Intermediate filament protein, coiled coil region domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]