SUPERFAMILY 1.75 HMM library and genome assignments server

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Nuclear receptor coactivator interlocking domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Nuclear receptor coactivator interlocking domain [ 69124]
Superfamily:   Nuclear receptor coactivator interlocking domain [ 69125]
Family:   Nuclear receptor coactivator interlocking domain [ 69126] (3)


Family statistics
Genomes (59) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 143 362 3
Proteins 143 362 3


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)genetic disease0.0001296Moderately InformativeDirect
Disease Ontology (DO)hereditary breast ovarian cancer syndrome0.0000006901InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.0571Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1439Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1513Least InformativeInherited
Mammalian Phenotype (MP)abnormal body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal T cell morphology0.005384Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.01015Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.01122Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.01151Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.01257Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.02038Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.2007Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.00009797InformativeDirect
Mammalian Phenotype (MP)increased lymphocyte cell number0.002263InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.005302InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.005615InformativeInherited
Mammalian Phenotype (MP)increased circulating leptin level0.000005021Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development0.00001465Highly InformativeDirect
Mammalian Phenotype (MP)enlarged spleen0.0007438Highly InformativeDirect

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)cardiovascular system0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)urogenital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)testis0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Nuclear receptor coactivator interlocking domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]