SUPERFAMILY 1.75 HMM library and genome assignments server

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Integrin domains family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Integrin domains [ 69179]
Family:   Integrin domains [ 69180] (2)


Family statistics
Genomes (68) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 997 2,361 5
Proteins 487 1,168 3


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2441Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.00004246Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.01108Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.12Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.4724Moderately InformativeInherited
Disease Ontology (DO)hemorrhagic disease0.0005409InformativeDirect
Disease Ontology (DO)autoimmune disease of skin and connective tissue0.001873InformativeInherited
Disease Ontology (DO)inherited blood coagulation disease0.00317InformativeInherited
Disease Ontology (DO)myeloid neoplasm0.003709InformativeInherited
Disease Ontology (DO)infertility0.000001774Highly InformativeDirect
Disease Ontology (DO)thrombocytopenia0.000006413Highly InformativeDirect
Disease Ontology (DO)multiple myeloma0.0005397Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.06318Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.09592Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1943Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.5156Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.7865Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.0652Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.07986Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.1678Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.2352Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.3737Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.5181Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.5218Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.00005263InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.01167InformativeInherited
Phenotypic Abnormality (PA)Internal hemorrhage0.01219InformativeInherited
Phenotypic Abnormality (PA)Abnormal platelet count0.0167InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.03574InformativeInherited
Phenotypic Abnormality (PA)Hearing impairment0.1552InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.4148InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the inner ear0.5324InformativeInherited
Phenotypic Abnormality (PA)Spontaneous hematomas0.000001946Highly InformativeDirect
Phenotypic Abnormality (PA)Gastrointestinal hemorrhage0.001633Highly InformativeInherited
Phenotypic Abnormality (PA)Diarrhea0.004423Highly InformativeInherited
Phenotypic Abnormality (PA)Sensorineural hearing impairment0.2183Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.0006223Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.0009517Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.006672Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.008418Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.2425Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.4368Least InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.002146Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.01794Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.08021Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.09584Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1048Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.1075Moderately InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.2483Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.3106Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.3126Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.3735Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.483Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.5798Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.6683Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.8207Moderately InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.0002204InformativeDirect
Mammalian Phenotype (MP)abnormal cell migration0.0002774InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.0007084InformativeDirect
Mammalian Phenotype (MP)abnormal response to injury0.0007645InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.004051InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.007543InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.03738InformativeInherited
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.05378InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.05574InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.07249InformativeInherited
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.1061InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1499InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte morphology0.2986InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.3018InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0.3951InformativeInherited
Mammalian Phenotype (MP)abnormal cell adhesion0.0000000006701Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0001234Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch size0.0002312Highly InformativeDirect
Mammalian Phenotype (MP)decreased CD4-positive, alpha beta T cell number0.0002631Highly InformativeDirect
Mammalian Phenotype (MP)blistering0.0003054Highly InformativeDirect
Mammalian Phenotype (MP)abnormal renal glomerulus basement membrane morphology0.0003632Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.0006008Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cellular extravasation0.0007514Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal nerve morphology0.004483Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hair growth0.01064Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb development0.01597Highly InformativeInherited
Mammalian Phenotype (MP)abnormal keratinocyte physiology0.0405Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.04701Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.2639Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)protein expression variant0Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0Moderately InformativeDirect
Worm Phenotype (WP)movement variant0Moderately InformativeDirect
Worm Phenotype (WP)cell type morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)level of protein expression variant0InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0InformativeDirect
Worm Phenotype (WP)protein metabolism variant0InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0InformativeDirect
Worm Phenotype (WP)protein expression reduced0Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0Highly InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)visible0Moderately InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect
Fly Phenotype (FP)lethal - all die before end of P-stage0Moderately InformativeDirect
Fly Phenotype (FP)decreased cell number0InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0InformativeDirect
Fly Phenotype (FP)partially lethal0Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)adult head0Moderately InformativeDirect
Fly Anatomy (FA)adult mesothoracic segment0Moderately InformativeDirect
Fly Anatomy (FA)gonad0Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0Moderately InformativeDirect
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)sense organ0Moderately InformativeDirect
Fly Anatomy (FA)late embryo0Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0Moderately InformativeDirect
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)epithelium0Moderately InformativeDirect
Fly Anatomy (FA)female organism0Moderately InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0Moderately InformativeDirect
Fly Anatomy (FA)embryonic/larval tracheal system0InformativeDirect
Fly Anatomy (FA)embryonic/larval neuron0InformativeDirect
Fly Anatomy (FA)embryonic/larval digestive system0InformativeDirect
Fly Anatomy (FA)eye0InformativeDirect
Fly Anatomy (FA)germline cell0InformativeDirect
Fly Anatomy (FA)cuticle0InformativeDirect
Fly Anatomy (FA)nerve0InformativeDirect
Fly Anatomy (FA)extended germ band embryo0InformativeDirect
Fly Anatomy (FA)dorsal closure embryo0InformativeDirect
Fly Anatomy (FA)midgut0InformativeDirect
Fly Anatomy (FA)primordium0InformativeDirect
Fly Anatomy (FA)adult peripheral nervous system0InformativeDirect
Fly Anatomy (FA)wing blade0InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval system0InformativeDirect
Fly Anatomy (FA)female germline cyst0InformativeDirect
Fly Anatomy (FA)epithelial tube0InformativeDirect
Fly Anatomy (FA)embryonic/larval trachea0Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval salivary gland0Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval midgut0Highly InformativeDirect
Fly Anatomy (FA)oocyte0Highly InformativeDirect
Fly Anatomy (FA)endocuticle0Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0Highly InformativeDirect
Fly Anatomy (FA)stage 7 embryo0Highly InformativeDirect
Fly Anatomy (FA)integumentary specialisation0Highly InformativeDirect
Fly Anatomy (FA)primary trachea0Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.8375Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.843Least InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.2604InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Integrin domains domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]