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C-terminal domain of adenylylcyclase associated protein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Single-stranded right-handed beta-helix [ 51125] (8)
Superfamily:   C-terminal domain of adenylylcyclase associated protein [ 69340]
Families:   C-terminal domain of adenylylcyclase associated protein [ 69341]


Superfamily statistics
Genomes (491) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,039 2,392 3
Proteins 1,036 2,389 3


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.04596 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.02085 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.2496 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.00809 Least Informative Inherited
Biological Process (BP) organelle organization 0.04632 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.02303 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.003958 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.01771 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.005683 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.04833 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.03713 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.001278 Moderately Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00001207 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0.00000002449 Informative Direct
Biological Process (BP) locomotion 0.0005051 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.001848 Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.0000004357 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.000000001741 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.00000000001915 Highly Informative Direct
Molecular Function (MF) binding 0.3909 Least Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.00004247 Informative Direct
Molecular Function (MF) enzyme binding 0.0003327 Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0047 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1203 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.00001256 Moderately Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0.000001273Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCell membrane0.000000000000009647Moderately InformativeDirect
Cellular componentCytoskeleton0.000000004832Moderately InformativeDirect
Molecular functionNucleotide-binding0.8537Least InformativeInherited
Molecular functionGTP-binding0.0003039InformativeDirect
Post-translational modificationActin-binding0InformativeDirect
Post-translational modificationGTPase activation0.0000000000324InformativeDirect
Post-translational modificationAcetylation0.0003775Least InformativeDirect
Post-translational modificationPalmitate0.0000002352Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.0000158Moderately InformativeDirect
Post-translational modificationMethylation0.00006531Moderately InformativeDirect
Post-translational modificationUbl conjugation0.0001989Moderately InformativeDirect
Post-translational modificationMyristate0.000000001218InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR013912 SSF69340 Protein matches
Abstract

Cyclase-associated protein (CAP) is a conserved two-domain protein that helps to activate the catalytic activity of adenylyl cyclase in the cyclase-bound state through interaction with Ras, which binds to the cyclase in a different region. With its other domain, CAP can bind monomeric actin and therefore also carries a cytoskeletal function. The protein is thus involved in Ras/cAMP-dependent signal transduction and most likely serves as an adapter protein translocating the adenylyl cyclase complex to the actin cytoskeleton. [PubMed1550959, PubMed7962207].

Structurally, CAP is a protein of 474 to 551 residues. The N- and C-terminal domains of CAP are connected by an intermediate section which contains a proline-rich region. In the yeast protein, this domain has been further divided into the P1 and P2 regions. While the P1 region is constituted by a 14 amino-acid sequence of unknown function, the P2 region exhibits a consensus SH3-binding motif (PXXP) and is necessary to target CAP to cortical actin patches. Dictyostelium CAP is a phosphatidylinositol 4,5-biphosphate (PIP2) regulated G-actin sequestering protein, which is present in the cytosol and shows enrichment at plasma-membrane regions. The cortical translocation is mediated by the N-terminal domain [PubMed12351838].

The CARP domain has been found as a tandem repeat in the C-terminal of many CAPs and also in the X-linked retinitis pigmentosa 2 gene product.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C-terminal domain of adenylylcyclase associated protein domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the C-terminal domain of adenylylcyclase associated protein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]