SUPERFAMILY 1.75 HMM library and genome assignments server

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Clathrin adaptor core protein family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   ARM repeat [ 48371] (23)
Family:   Clathrin adaptor core protein [ 74771] (2)


Family statistics
Genomes (506) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,809 11,413 5
Proteins 3,794 11,396 5


Human Phenotype (HP)

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show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.04195Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.114Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skull size0Moderately InformativeDirect
Phenotypic Abnormality (PA)Behavioral abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cerebrum0Moderately InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of movement0.1411Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1613Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.4328Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Microcephaly0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the hip joint0.0007028InformativeDirect
Phenotypic Abnormality (PA)Abnormal lip morphology0.07864InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.1419InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the philtrum0.0002335Highly InformativeDirect
Phenotypic Abnormality (PA)Coarse facial features0.0003074Highly InformativeDirect
Phenotypic Abnormality (PA)Cerebellar atrophy0.0007287Highly InformativeDirect
Phenotypic Abnormality (PA)Atrophy/Degeneration affecting the cerebrum0.01963Highly InformativeInherited
Phenotypic Abnormality (PA)Gait disturbance0.1394Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.0004789Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.000582InformativeDirect
Mammalian Phenotype (MP)abnormal hearing electrophysiology0.0002774Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.02197Least InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.00008195Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.0006959Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.001435Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.001457Moderately InformativeInherited
Worm Phenotype (WP)germ cell differentiation variant0.002347Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.0032Moderately InformativeInherited
Worm Phenotype (WP)germ cell development variant0.01084Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.06693Moderately InformativeInherited
Worm Phenotype (WP)cell cycle variant0.1401Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.3667Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.3989Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.4736Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.7008Moderately InformativeInherited
Worm Phenotype (WP)diplotene progression during oogenesis variant0.00004946InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.00009649InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.000167InformativeDirect
Worm Phenotype (WP)rachis morphology variant0.0001767InformativeDirect
Worm Phenotype (WP)gonad development variant0.0003622InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0.0007872InformativeDirect
Worm Phenotype (WP)oocyte septum formation variant0.000004962Highly InformativeDirect
Worm Phenotype (WP)diplotene region organization variant0.000009073Highly InformativeDirect
Worm Phenotype (WP)rachis narrow0.00003714Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.00005351Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 75 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a ARM repeat domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]