SUPERFAMILY 1.75 HMM library and genome assignments server

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Lamin A/C globular tail domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Lamin A/C globular tail domain [ 74853]
Family:   Lamin A/C globular tail domain [ 74854]


Family statistics
Genomes (88) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 298 813 3
Proteins 298 809 3


Disease Ontology (DO)

(
show details) Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the ear0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of central motor function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of higher mental function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Neurodevelopmental delay0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of movement0Moderately InformativeDirect
Phenotypic Abnormality (PA)Hearing impairment0InformativeDirect
Phenotypic Abnormality (PA)Intellectual disability0InformativeDirect
Phenotypic Abnormality (PA)Gait disturbance0Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal head morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skin morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal neuron morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal spinal nerve morphology0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.05447Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1104Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.000175Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0009845Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.001002Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.003167Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.06783Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.1482Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0008018InformativeDirect
Worm Phenotype (WP)locomotion reduced0.002161InformativeInherited
Worm Phenotype (WP)antibody staining variant0.00000001961Highly InformativeDirect
Worm Phenotype (WP)muscle system development variant0.000002935Highly InformativeDirect
Worm Phenotype (WP)paralyzed0.00001258Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Lamin A/C globular tail domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Internal database links ]