SUPERFAMILY 1.75 HMM library and genome assignments server

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Ngr ectodomain-like family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   L domain-like [ 52058] (8)
Family:   Ngr ectodomain-like [ 75142] (6)


Family statistics
Genomes (94) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 803 2,482 14
Proteins 802 2,479 14


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.01216Least InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Peroxidases0.000000000001504InformativeDirect
Enzyme Commission (EC)Peroxidase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.05548Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1655Moderately InformativeInherited
Disease Ontology (DO)inherited blood coagulation disease0.0003166InformativeDirect
Disease Ontology (DO)eye disease0.002218InformativeInherited
Disease Ontology (DO)myopia0.0000692Highly InformativeDirect
Disease Ontology (DO)corneal disease0.0008107Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.6096Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.9183Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.9474Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.9649Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.9769Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.1464Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.3628Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.5591Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.6524Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.6554Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.8223Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.8361Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.9361Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.9605Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal urine cytology0.007276InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the menstrual cycle0.008445InformativeInherited
Phenotypic Abnormality (PA)Abnormality of coagulation0.05558InformativeInherited
Phenotypic Abnormality (PA)Abnormal platelet count0.1934InformativeInherited
Phenotypic Abnormality (PA)Internal hemorrhage0.2624InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.2952InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.3638InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.3766InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.545InformativeInherited
Phenotypic Abnormality (PA)Prolonged bleeding following procedure0.00006357Highly InformativeDirect
Phenotypic Abnormality (PA)Spontaneous hematomas0.000103Highly InformativeDirect
Phenotypic Abnormality (PA)Menorrhagia0.0005778Highly InformativeDirect
Phenotypic Abnormality (PA)Hematuria0.007276Highly InformativeInherited
Phenotypic Abnormality (PA)Epistaxis0.008809Highly InformativeInherited
Phenotypic Abnormality (PA)Gastrointestinal hemorrhage0.03444Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1199Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.6563Least InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.1842Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.2399Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.2736Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.5505Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.6298Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.6974Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.8046Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.873Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.9821Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.01704InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.03826InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system tract morphology0.06454InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1057InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.1137InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.1651InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.2818InformativeInherited
Mammalian Phenotype (MP)abnormal tendon morphology0.00001683Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord ventral commissure morphology0.00001833Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord white matter morphology0.004794Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epididymis morphology0.005982Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cornea morphology0.008666Highly InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.02029Highly InformativeInherited
Mammalian Phenotype (MP)arthritis0.03288Highly InformativeInherited
Mammalian Phenotype (MP)decreased bone mass0.05968Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.06292Least InformativeInherited
Fly Anatomy (FA)tagma0.2015Least InformativeInherited
Fly Anatomy (FA)segment0.2451Least InformativeInherited
Fly Anatomy (FA)larva0.3492Least InformativeInherited
Fly Anatomy (FA)nervous system0.709Least InformativeInherited
Fly Anatomy (FA)larval tagma0.05474Moderately InformativeInherited
Fly Anatomy (FA)abdomen0.1145Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.1897Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.6265Moderately InformativeInherited
Fly Anatomy (FA)nerve0.01468InformativeInherited
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.04865InformativeInherited
Fly Anatomy (FA)larval abdominal segment0.1694InformativeInherited
Fly Anatomy (FA)intersegmental nerve0.001424Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.01056Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.2836InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.0002273Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.009085Least InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Peroxidases0.000000000001292Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 50 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a L domain-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]