SUPERFAMILY 1.75 HMM library and genome assignments server

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Ngr ectodomain-like family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   L domain-like [ 52058] (8)
Family:   Ngr ectodomain-like [ 75142] (6)


Family statistics
Genomes (94) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 803 2,482 14
Proteins 802 2,479 14


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.01216Least InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Peroxidases0.000000000001504InformativeDirect
Enzyme Commission (EC)Peroxidase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.05548Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1655Moderately InformativeInherited
Disease Ontology (DO)inherited blood coagulation disease0.0003166InformativeDirect
Disease Ontology (DO)eye disease0.002218InformativeInherited
Disease Ontology (DO)myopia0.0000692Highly InformativeDirect
Disease Ontology (DO)corneal disease0.0008107Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.6297Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.9245Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.952Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.9652Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.9798Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.153Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.3743Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.5712Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.6603Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.662Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.8297Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.8439Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.9638Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal urine cytology0.007266InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the menstrual cycle0.008457InformativeInherited
Phenotypic Abnormality (PA)Abnormality of coagulation0.05614InformativeInherited
Phenotypic Abnormality (PA)Abnormal platelet count0.2005InformativeInherited
Phenotypic Abnormality (PA)Internal hemorrhage0.2613InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.3037InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.3759InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.3844InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.5486InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.9388InformativeInherited
Phenotypic Abnormality (PA)Prolonged bleeding following procedure0.00006118Highly InformativeDirect
Phenotypic Abnormality (PA)Spontaneous hematomas0.0000991Highly InformativeDirect
Phenotypic Abnormality (PA)Menorrhagia0.000558Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal platelet function0.00183Highly InformativeInherited
Phenotypic Abnormality (PA)Hematuria0.007266Highly InformativeInherited
Phenotypic Abnormality (PA)Epistaxis0.008539Highly InformativeInherited
Phenotypic Abnormality (PA)Gastrointestinal hemorrhage0.03436Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1199Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.6563Least InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.1842Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.2399Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.2736Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.5505Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.6298Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.6974Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.8046Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.873Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.9821Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.01704InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.03826InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system tract morphology0.06454InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.1057InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.1137InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.1651InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.2818InformativeInherited
Mammalian Phenotype (MP)abnormal tendon morphology0.00001683Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord ventral commissure morphology0.00001833Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord white matter morphology0.004794Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epididymis morphology0.005982Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cornea morphology0.008666Highly InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.02029Highly InformativeInherited
Mammalian Phenotype (MP)arthritis0.03288Highly InformativeInherited
Mammalian Phenotype (MP)decreased bone mass0.05968Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.05818Least InformativeInherited
Fly Anatomy (FA)tagma0.1891Least InformativeInherited
Fly Anatomy (FA)segment0.2447Least InformativeInherited
Fly Anatomy (FA)larva0.369Least InformativeInherited
Fly Anatomy (FA)nervous system0.6931Least InformativeInherited
Fly Anatomy (FA)larval tagma0.05084Moderately InformativeInherited
Fly Anatomy (FA)abdomen0.1152Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.1864Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.629Moderately InformativeInherited
Fly Anatomy (FA)nerve0.01447InformativeInherited
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.04938InformativeInherited
Fly Anatomy (FA)larval abdominal segment0.173InformativeInherited
Fly Anatomy (FA)intersegmental nerve0.001378Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.007932Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.2477InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.0002176Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.009024Least InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Peroxidases0.0000000000013Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 50 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a L domain-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]