SUPERFAMILY 1.75 HMM library and genome assignments server

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Noncollagenous (NC1) domain of collagen IV family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   C-type lectin-like [ 56435]
Superfamily:   C-type lectin-like [ 56436] (8)
Family:   Noncollagenous (NC1) domain of collagen IV [ 75585]


Family statistics
Genomes (140) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,410 3,768 8
Proteins 737 1,991 4


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)syndrome0Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.000002507Moderately InformativeDirect
Disease Ontology (DO)glomerulonephritis0.0000005921InformativeDirect
Disease Ontology (DO)kidney failure0.05801Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1954Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.2Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.2567Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.3186Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.01175Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.01891Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.02299Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.06201Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.1648Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal urine cytology0.000005379InformativeDirect
Phenotypic Abnormality (PA)Abnormal renal physiology0.001865InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.001905InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lens0.003063InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.007179InformativeInherited
Phenotypic Abnormality (PA)Corneal erosion0.000002837Highly InformativeDirect
Phenotypic Abnormality (PA)Hematuria0.000005379Highly InformativeDirect
Phenotypic Abnormality (PA)Nephritis0.00007861Highly InformativeDirect
Phenotypic Abnormality (PA)Renal insufficiency0.0001344Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of refraction0.000564Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.07877Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1487Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2574Least InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.0007561Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal eye morphology0.004002Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.008185Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.01103Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.027Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.03867Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.00006464InformativeDirect
Mammalian Phenotype (MP)abnormal renal tubule morphology0.0002171InformativeDirect
Mammalian Phenotype (MP)abnormal amino acid level0.000367InformativeDirect
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.000426InformativeDirect
Mammalian Phenotype (MP)abnormal erythrocyte morphology0.0004577InformativeDirect
Mammalian Phenotype (MP)abnormal kidney physiology0.2631InformativeInherited
Mammalian Phenotype (MP)abnormal renal glomerulus basement membrane morphology0.000001002Highly InformativeDirect
Mammalian Phenotype (MP)glomerulosclerosis0.000004524Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating creatinine level0.000005519Highly InformativeDirect
Mammalian Phenotype (MP)abnormal lens morphology0.000007868Highly InformativeDirect
Mammalian Phenotype (MP)increased blood urea nitrogen level0.00004038Highly InformativeDirect
Mammalian Phenotype (MP)decreased myeloid cell number0.0005793Highly InformativeDirect
Mammalian Phenotype (MP)renal/urinary system inflammation0.003355Highly InformativeInherited
Mammalian Phenotype (MP)abnormal erythrocyte cell number0.04314Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hematocrit0.0483Highly InformativeInherited
Mammalian Phenotype (MP)abnormal kidney size0.09553Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)adipose tissue0Highly InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 124 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a C-type lectin-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]