SUPERFAMILY 1.75 HMM library and genome assignments server

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Tandem AAA-ATPase domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   P-loop containing nucleoside triphosphate hydrolases [ 52539]
Superfamily:   P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
Family:   Tandem AAA-ATPase domain [ 81268] (23)


Family statistics
Genomes (3,247) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 64,959 411,162 69
Proteins 44,571 273,120 50


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red1Moderately InformativeInherited
Enzyme Commission (EC)RNA helicase0InformativeDirect
Enzyme Commission (EC)Exodeoxyribonucleases producing 5'-phosphomonoeste0.000000000001566Highly InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0.0001972Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0.2328Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.004609Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.1107Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal facial shape0.04463InformativeInherited
Phenotypic Abnormality (PA)Hematological neoplasm0.0005311Highly InformativeDirect
Phenotypic Abnormality (PA)Narrow face0.0005417Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.001966Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.01238Least InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.08217Moderately InformativeInherited
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0.0002976InformativeDirect
Mammalian Phenotype (MP)chromosomal instability0.005617Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cell nucleus morphology0.02086Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.002997Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.002997Least InformativeInherited
Worm Phenotype (WP)cell development variant0.007944Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.607Least InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.00005186Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.04482Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1973Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.8106Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.00000000038InformativeDirect
Worm Phenotype (WP)vulva morphology variant0.000001536InformativeDirect
Worm Phenotype (WP)sick0.00002515InformativeDirect
Worm Phenotype (WP)cell stress response variant0.0001623InformativeDirect
Worm Phenotype (WP)organism UV response variant0.000000000001314Highly InformativeDirect
Worm Phenotype (WP)RNAi response variant0.00002235Highly InformativeDirect
Worm Phenotype (WP)neurite development variant0.0000843Highly InformativeDirect
Worm Phenotype (WP)germ cell physiology variant0.0004867Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic appearance variant0.04947Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)radiation resistance0.00009948Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.0001722Least InformativeDirect
Fly Phenotype (FP)stress response defective0.1261Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.02977Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.1443Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.0236Moderately InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0.00007642Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0.0001474Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0.002734Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.004267Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.03864Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.2872Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.5477Least InformativeInherited
Xenopus ANatomical entity (XAN)testis0.000008106Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.06026Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.07758Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.122Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.799Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical entity in vitro0.00001724InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.00002226InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.000002149Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.00001975Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.00002206Highly InformativeDirect
Xenopus ANatomical entity (XAN)ventral blood island0.00003964Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastopore lip0.0006002Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)seed0.00000006578Least InformativeDirect
Plant ANatomical entity (PAN)shoot apex0.00001568Least InformativeDirect
Plant ANatomical entity (PAN)branch0.00005879Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0.008386Least InformativeInherited
Plant structure DEvelopment stage (PDE)D bilateral stage0.0000000004658Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0.0004592Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on ester bonds1Moderately InformativeInherited
Enzyme Commission (EC)Acting on ATP; involved in cellular and subcellular movement0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate1InformativeInherited
Enzyme Commission (EC)Translocases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0.002228Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 512 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a P-loop containing nucleoside triphosphate hydrolases domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]