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Extended AAA-ATPase domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   P-loop containing nucleoside triphosphate hydrolases [ 52539]
Superfamily:   P-loop containing nucleoside triphosphate hydrolases [ 52540] (24)
Family:   Extended AAA-ATPase domain [ 81269] (28)


Family statistics
Genomes (3,262) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 69,729 444,459 60
Proteins 59,159 380,602 56


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)1Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)DNA-directed DNA polymerase0.0000000001761InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0.001117Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.002397Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.03348Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.04907Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.07405Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.1572Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.5701Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.8774Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.0003666Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0.005057Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of central motor function0.009785Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.0179Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle tone0.1177Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.1628Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.1811Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system morphology0.1811Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.4642Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.4929Moderately InformativeInherited
Phenotypic Abnormality (PA)Hearing impairment0.0004091InformativeDirect
Phenotypic Abnormality (PA)Abnormal cerebellum morphology0.0008252InformativeDirect
Phenotypic Abnormality (PA)Abnormal nervous system electrophysiology0.01374InformativeInherited
Phenotypic Abnormality (PA)Hypertonia0.02927InformativeInherited
Phenotypic Abnormality (PA)Peripheral neuropathy0.111InformativeInherited
Phenotypic Abnormality (PA)Abnormal involuntary eye movements0.1207InformativeInherited
Phenotypic Abnormality (PA)Spasticity0.00004083Highly InformativeDirect
Phenotypic Abnormality (PA)Nystagmus0.0002142Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the stomach0.0008294Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of female external genitalia0.004383Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of coordination0.05715Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.005735Least InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.1321Moderately InformativeInherited
Mammalian Phenotype (MP)embryonic lethality prior to organogenesis0.0001696InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.000003375Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.000003375Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0002493Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.005695Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.0327Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.06556Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0000000001612Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.0000008807Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.0000009833Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.001237Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.1156Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.14Moderately InformativeInherited
Worm Phenotype (WP)germ cell differentiation variant0.4726Moderately InformativeInherited
Worm Phenotype (WP)cytokinesis variant emb0.0000006394InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.000001084InformativeDirect
Worm Phenotype (WP)nuclear appearance variant0.000009927InformativeDirect
Worm Phenotype (WP)sick0.0004586InformativeDirect
Worm Phenotype (WP)spindle variant0.122InformativeInherited
Worm Phenotype (WP)nuclear positioning variant0.2001InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.2098InformativeInherited
Worm Phenotype (WP)multiple nuclei0.000000004161Highly InformativeDirect
Worm Phenotype (WP)cell cycle arrest0.0000007619Highly InformativeDirect
Worm Phenotype (WP)endoplasmic reticulum morphology variant0.000009048Highly InformativeDirect
Worm Phenotype (WP)germ cell compartment anucleate0.00002699Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic appearance variant0.0002157Highly InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased0.0007438Highly InformativeDirect
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.01143Highly InformativeInherited
Worm Phenotype (WP)nuclear appearance number defective early emb0.01196Highly InformativeInherited
Worm Phenotype (WP)nucleus defective early emb0.01196Highly InformativeInherited
Worm Phenotype (WP)pronuclear morphology defective early emb0.01196Highly InformativeInherited
Worm Phenotype (WP)pronuclear nuclear appearance defective early emb0.01365Highly InformativeInherited
Worm Phenotype (WP)nuclear morphology variation early emb0.01553Highly InformativeInherited
Worm Phenotype (WP)lineage variant0.01781Highly InformativeInherited
Worm Phenotype (WP)germ cell compartment size variant0.4578Highly InformativeInherited
Worm Phenotype (WP)cleavage furrow defective early emb0.4847Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0.005388Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.0245Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.08648Least InformativeInherited
Xenopus ANatomical entity (XAN)testis0.0001818Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferases1Least InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.1353Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect
Enzyme Commission (EC)Acting on ATP; involved in cellular and subcellular movement0InformativeDirect
Enzyme Commission (EC)DNA-directed DNA polymerase0.0000000003847InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides1InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 512 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a P-loop containing nucleoside triphosphate hydrolases domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]