SUPERFAMILY 1.75 HMM library and genome assignments server

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NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   E set domains [ 81296] (23)
Family:   NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain [ 81279] (7)


Family statistics
Genomes (130) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 947 2,684 38
Proteins 947 2,684 38


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.04468Least InformativeInherited
Disease Ontology (DO)gastrointestinal system cancer0.04262Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.06045Moderately InformativeInherited
Disease Ontology (DO)cell type benign neoplasm0.02601InformativeInherited
Disease Ontology (DO)large intestine cancer0.1032InformativeInherited
Disease Ontology (DO)hemangioma0.00004836Highly InformativeDirect
Disease Ontology (DO)colon cancer0.0009581Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.0859Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.4691Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.01094Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.1017Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.1349Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.01405InformativeInherited
Phenotypic Abnormality (PA)Abnormal hair quantity0.01564InformativeInherited
Phenotypic Abnormality (PA)Leukopenia0.0005969Highly InformativeDirect
Phenotypic Abnormality (PA)Alopecia0.0006605Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.001807Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.001971Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.003051Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.00449Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.007042Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.01122Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.09717Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.00000006445Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal B cell morphology0.0000002532Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal T cell morphology0.00000568Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.000006668Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.00001422Moderately InformativeDirect
Mammalian Phenotype (MP)increased hematopoietic cell number0.00004379Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.00004739Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle physiology0.00006115Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.0001094Moderately InformativeDirect
Mammalian Phenotype (MP)decreased hematopoietic cell number0.0001868Moderately InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to infection0.0002121Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.0003331Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology0.0007321Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.00213Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.005062Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.008114Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.009755Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.01556Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.01615Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.01744Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.02134Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.05971Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.0788Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.1189Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.249Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.2675Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.3755Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.3803Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.4114Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.5513Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.6448Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.000000009831InformativeDirect
Mammalian Phenotype (MP)abnormal immunoglobulin level0.00000002839InformativeDirect
Mammalian Phenotype (MP)abnormal B cell proliferation0.0000001781InformativeDirect
Mammalian Phenotype (MP)decreased T cell number0.0000003261InformativeDirect
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.00005212InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.00007402InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.0001536InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0003863InformativeDirect
Mammalian Phenotype (MP)abnormal jaw morphology0.0004758InformativeDirect
Mammalian Phenotype (MP)postnatal growth retardation0.0005646InformativeDirect
Mammalian Phenotype (MP)abnormal spleen morphology0.001933InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.00286InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.00574InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.008008InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.009803InformativeInherited
Mammalian Phenotype (MP)abnormal placenta morphology0.01222InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.0158InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage morphology0.02472InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.1019InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.234InformativeInherited
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.5703InformativeInherited
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.5805InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0.6404InformativeInherited
Mammalian Phenotype (MP)decreased B cell proliferation0.000000007752Highly InformativeDirect
Mammalian Phenotype (MP)lung inflammation0.00000002625Highly InformativeDirect
Mammalian Phenotype (MP)abnormal trigeminal nerve morphology0.0000003848Highly InformativeDirect
Mammalian Phenotype (MP)abnormal T cell proliferation0.0000006532Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spleen germinal center morphology0.00002472Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch size0.00002688Highly InformativeDirect
Mammalian Phenotype (MP)decreased dendritic cell number0.00003109Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.00004648Highly InformativeDirect
Mammalian Phenotype (MP)increased IgG2a level0.00008382Highly InformativeDirect
Mammalian Phenotype (MP)abnormal dorsal aorta morphology0.0002838Highly InformativeDirect
Mammalian Phenotype (MP)abnormal IgG2b level0.0003317Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.0005595Highly InformativeDirect
Mammalian Phenotype (MP)decreased CD8-positive, alpha-beta T cell number0.0006292Highly InformativeDirect
Mammalian Phenotype (MP)decreased CD4-positive, alpha beta T cell number0.0009081Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord white matter morphology0.00141Highly InformativeInherited
Mammalian Phenotype (MP)increased bone mass0.00189Highly InformativeInherited
Mammalian Phenotype (MP)abnormal placenta labyrinth morphology0.001992Highly InformativeInherited
Mammalian Phenotype (MP)abnormal anxiety-related response0.01014Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle tissue morphology0.02455Highly InformativeInherited
Mammalian Phenotype (MP)abnormal large intestine morphology0.04985Highly InformativeInherited
Mammalian Phenotype (MP)decreased IgG level0.1623Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)immune response defective0.0008811InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)nervous system0.09938Least InformativeInherited
Fly Anatomy (FA)segment0.3477Least InformativeInherited
Fly Anatomy (FA)sense organ0Moderately InformativeDirect
Fly Anatomy (FA)cell cluster organ0Moderately InformativeDirect
Fly Anatomy (FA)adult mesothoracic segment0.007663Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.01036Moderately InformativeInherited
Fly Anatomy (FA)neuron0.04603Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.06253Moderately InformativeInherited
Fly Anatomy (FA)mesothoracic tergum0.000001176InformativeDirect
Fly Anatomy (FA)anatomical space0.004294InformativeInherited
Fly Anatomy (FA)mechanosensory system0.02056InformativeInherited
Fly Anatomy (FA)embryonic/larval neuron0.05376InformativeInherited
Fly Anatomy (FA)chaeta0.716InformativeInherited
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0002679Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 164 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a E set domains domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]