SUPERFAMILY 1.75 HMM library and genome assignments server

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DEATH domain, DD family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DEATH domain [ 47985]
Superfamily:   DEATH domain [ 47986] (4)
Family:   DEATH domain, DD [ 81312] (8)


Family statistics
Genomes (81) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 522 1,398 10
Proteins 522 1,398 10


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)gastrointestinal system disease0.1477Moderately InformativeInherited
Disease Ontology (DO)gastritis0.0007332Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.002402Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.07064Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1347Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.1835Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.196Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.7175Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.003983Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.01669Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.02412Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.02723Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.08773Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.116Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.2149Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.4124Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin physiology0.00002251InformativeDirect
Phenotypic Abnormality (PA)Splenomegaly0.0006739InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lymph nodes0.007047InformativeInherited
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.02856InformativeInherited
Phenotypic Abnormality (PA)Abnormal cellular physiology0.0289InformativeInherited
Phenotypic Abnormality (PA)Abnormal uvea morphology0.04552InformativeInherited
Phenotypic Abnormality (PA)Abnormal platelet count0.06172InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.06542InformativeInherited
Phenotypic Abnormality (PA)Vasculitis0.0001045Highly InformativeDirect
Phenotypic Abnormality (PA)Uveitis0.0005976Highly InformativeDirect
Phenotypic Abnormality (PA)Hematological neoplasm0.003376Highly InformativeInherited
Phenotypic Abnormality (PA)Autoimmunity0.04847Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.0001009Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.01369Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.01661Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.02006Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.336Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7349Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.00002085Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.0001665Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.0007484Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.002495Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.006733Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.01195Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.0209Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.04551Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.07147Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.08121Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.1265Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1615Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.2166Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.2314Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.2434Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.2825Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.5669Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.638Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interleukin level0.000002932InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0004334InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.0006748InformativeDirect
Mammalian Phenotype (MP)abnormal jaw morphology0.01397InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.01527InformativeInherited
Mammalian Phenotype (MP)abnormal mouth morphology0.02502InformativeInherited
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.03036InformativeInherited
Mammalian Phenotype (MP)increased lymphocyte cell number0.03901InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.04693InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.07946InformativeInherited
Mammalian Phenotype (MP)abnormal immunoglobulin level0.144InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.2776InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.8921InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch size0.0000005256Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.00001811Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spleen germinal center morphology0.00005258Highly InformativeDirect
Mammalian Phenotype (MP)abnormal IgG2b level0.0003619Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.0005723Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tooth morphology0.0006054Highly InformativeDirect
Mammalian Phenotype (MP)enlarged lymph nodes0.0007517Highly InformativeDirect
Mammalian Phenotype (MP)increased IgG2a level0.000987Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage B cell morphology0.001288Highly InformativeInherited
Mammalian Phenotype (MP)increased immature B cell number0.01882Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Least InformativeDirect
Worm Phenotype (WP)organ system development variant0.00125Moderately InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.00002127InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a DEATH domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]