SUPERFAMILY 1.75 HMM library and genome assignments server

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Caspase recruitment domain, CARD family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DEATH domain [ 47985]
Superfamily:   DEATH domain [ 47986] (4)
Family:   Caspase recruitment domain, CARD [ 81313] (5)


Family statistics
Genomes (65) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 251 693 9
Proteins 251 693 9


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)gastrointestinal system disease0.06356Moderately InformativeInherited
Disease Ontology (DO)syndrome0.4755Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.002896InformativeInherited
Disease Ontology (DO)irritable bowel syndrome0.0002962Highly InformativeDirect
Disease Ontology (DO)Crohn's disease0.0004658Highly InformativeDirect
Disease Ontology (DO)colitis0.0007418Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0.147Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.1528Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.2953Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.3233Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.01009Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.06867Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.0841Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.09204Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymph nodes0.0003902InformativeDirect
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.0005052InformativeDirect
Phenotypic Abnormality (PA)Fever0.0009659InformativeDirect
Phenotypic Abnormality (PA)Abnormal uvea morphology0.004378InformativeInherited
Phenotypic Abnormality (PA)Uveitis0.000001551Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.001261Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.003275Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.01123Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.06425Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.1773Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8309Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.000005262Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.00001052Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.0006151Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.01274Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.06151Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.08788Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.1086Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.1491Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.8516Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.000001651InformativeDirect
Mammalian Phenotype (MP)abnormal interferon-gamma secretion0.000011InformativeDirect
Mammalian Phenotype (MP)abnormal circulating interleukin level0.001027InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland physiology0.02407InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.07318InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.297InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.000000005777Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating interferon-gamma level0.0002268Highly InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to induced colitis0.0004265Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating interleukin-18 level0.0005232Highly InformativeDirect
Mammalian Phenotype (MP)abnormal immune organ physiology0.05038Highly InformativeInherited
Mammalian Phenotype (MP)abnormal T cell apoptosis0.06137Highly InformativeInherited
Mammalian Phenotype (MP)decreased acute inflammation0.08657Highly InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to infection0.4106Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.00000000002198Least InformativeDirect
Enzyme Commission (EC)Transferases0.964Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.03579Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.0001912InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.002337InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.00000007266Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a DEATH domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]