SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Caspase recruitment domain, CARD family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DEATH domain [ 47985]
Superfamily:   DEATH domain [ 47986] (4)
Family:   Caspase recruitment domain, CARD [ 81313] (5)


Family statistics
Genomes (65) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 251 693 9
Proteins 251 693 9


Enzyme Commission (EC)

(
show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)gastrointestinal system disease0.06356Moderately InformativeInherited
Disease Ontology (DO)syndrome0.4755Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.002896InformativeInherited
Disease Ontology (DO)irritable bowel syndrome0.0002962Highly InformativeDirect
Disease Ontology (DO)Crohn's disease0.0004658Highly InformativeDirect
Disease Ontology (DO)colitis0.0007418Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0.1446Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.1525Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.2884Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.3169Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.00967Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.03146Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.06609Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.08897Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymph nodes0.000396InformativeDirect
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.0005248InformativeDirect
Phenotypic Abnormality (PA)Fever0.00095InformativeDirect
Phenotypic Abnormality (PA)Abnormal uvea morphology0.00443InformativeInherited
Phenotypic Abnormality (PA)Uveitis0.000001608Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.001262Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.003267Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.0112Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.06431Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.1773Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8307Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.00000527Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.00001043Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.000615Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.01267Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.06149Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.08754Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.1083Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.1487Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.8522Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.000001655InformativeDirect
Mammalian Phenotype (MP)abnormal interferon-gamma secretion0.00001102InformativeDirect
Mammalian Phenotype (MP)abnormal circulating interleukin level0.001027InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland physiology0.02407InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.07315InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.2969InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.000000005781Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating interferon-gamma level0.0002267Highly InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to induced colitis0.0004264Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating interleukin-18 level0.000523Highly InformativeDirect
Mammalian Phenotype (MP)abnormal immune organ physiology0.05045Highly InformativeInherited
Mammalian Phenotype (MP)abnormal T cell apoptosis0.06134Highly InformativeInherited
Mammalian Phenotype (MP)decreased acute inflammation0.08653Highly InformativeInherited
Mammalian Phenotype (MP)decreased susceptibility to infection0.4106Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.00000000002227Least InformativeDirect
Enzyme Commission (EC)Transferases0.9661Least InformativeInherited
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.03584Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.0001902InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00232InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.00000007298Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a DEATH domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]