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Rel/Dorsal transcription factors, DNA-binding domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   p53-like transcription factors [ 49417] (7)
Family:   Rel/Dorsal transcription factors, DNA-binding domain [ 81315] (6)


Family statistics
Genomes (126) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,071 3,093 25
Proteins 1,071 3,087 25


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.08532Least InformativeInherited
Disease Ontology (DO)gastrointestinal system cancer0.02076Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.02957Moderately InformativeInherited
Disease Ontology (DO)cell type benign neoplasm0.01462InformativeInherited
Disease Ontology (DO)large intestine cancer0.06141InformativeInherited
Disease Ontology (DO)hemangioma0.00002297Highly InformativeDirect
Disease Ontology (DO)colon cancer0.0004785Highly InformativeDirect
Disease Ontology (DO)nasopharynx carcinoma0.0009468Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.0636Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1811Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0Moderately InformativeDirect
Phenotypic Abnormality (PA)Unusual infection0.005005Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.01007Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.01061Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.03709Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.07983Moderately InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.003833InformativeInherited
Phenotypic Abnormality (PA)Respiratory tract infection0.1683InformativeInherited
Phenotypic Abnormality (PA)Otitis media0.000103Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.0004081Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.0005858Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.007124Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.0976Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal B cell morphology0.00000004278Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0.0000002087Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0000005122Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal T cell morphology0.0000008172Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.0000009516Moderately InformativeDirect
Mammalian Phenotype (MP)increased hematopoietic cell number0.000005808Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.000006265Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00001438Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle physiology0.00001957Moderately InformativeDirect
Mammalian Phenotype (MP)decreased hematopoietic cell number0.00002426Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology0.00009585Moderately InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to infection0.0002271Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.000561Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.001008Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.001491Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.003838Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.003939Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.008975Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.01103Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.01426Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.02407Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.07994Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.1055Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.249Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.3755Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.3803Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.4609Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.6124Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.0000000004419InformativeDirect
Mammalian Phenotype (MP)abnormal immunoglobulin level0.000000005558InformativeDirect
Mammalian Phenotype (MP)abnormal B cell proliferation0.000000007542InformativeDirect
Mammalian Phenotype (MP)decreased T cell number0.00000005418InformativeDirect
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.000003035InformativeDirect
Mammalian Phenotype (MP)abnormal jaw morphology0.000057InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.00009078InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0001056InformativeDirect
Mammalian Phenotype (MP)postnatal growth retardation0.0003057InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.0005371InformativeDirect
Mammalian Phenotype (MP)abnormal prenatal body size0.001237InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic growth/weight/body size0.002166InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.00283InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.003979InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.004193InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.008008InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.009706InformativeInherited
Mammalian Phenotype (MP)abnormal long bone morphology0.01352InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.02204InformativeInherited
Mammalian Phenotype (MP)abnormal macrophage morphology0.04352InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.09443InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.101InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.1612InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton development0.1754InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.2258InformativeInherited
Mammalian Phenotype (MP)abnormal heart size0.3216InformativeInherited
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.4227InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0.483InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to autoimmune disorder0.538InformativeInherited
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.6705InformativeInherited
Mammalian Phenotype (MP)decreased B cell proliferation0.0000000002983Highly InformativeDirect
Mammalian Phenotype (MP)lung inflammation0.0000000004677Highly InformativeDirect
Mammalian Phenotype (MP)abnormal trigeminal nerve morphology0.00000005448Highly InformativeDirect
Mammalian Phenotype (MP)abnormal T cell proliferation0.0000006913Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord white matter morphology0.000002437Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spleen germinal center morphology0.000003967Highly InformativeDirect
Mammalian Phenotype (MP)abnormal Peyer's patch size0.000006695Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.00001184Highly InformativeDirect
Mammalian Phenotype (MP)increased IgG2a level0.00002181Highly InformativeDirect
Mammalian Phenotype (MP)abnormal large intestine morphology0.0000368Highly InformativeDirect
Mammalian Phenotype (MP)abnormal IgG2b level0.00009074Highly InformativeDirect
Mammalian Phenotype (MP)decreased CD8-positive, alpha-beta T cell number0.0001195Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.0001561Highly InformativeDirect
Mammalian Phenotype (MP)decreased CD4-positive, alpha beta T cell number0.0001779Highly InformativeDirect
Mammalian Phenotype (MP)decreased dendritic cell number0.0002779Highly InformativeDirect
Mammalian Phenotype (MP)internal hemorrhage0.0003084Highly InformativeDirect
Mammalian Phenotype (MP)abnormal long bone epiphyseal plate morphology0.000587Highly InformativeDirect
Mammalian Phenotype (MP)increased bone mass0.00189Highly InformativeInherited
Mammalian Phenotype (MP)abnormal anxiety-related response0.003265Highly InformativeInherited
Mammalian Phenotype (MP)enlarged heart0.01206Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus size0.03002Highly InformativeInherited
Mammalian Phenotype (MP)decreased IgG level0.05931Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)immune response defective0.00007518InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)adult mesothoracic segment0Moderately InformativeDirect
Fly Anatomy (FA)sense organ0Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0Moderately InformativeDirect
Fly Anatomy (FA)cell cluster organ0Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0Moderately InformativeDirect
Fly Anatomy (FA)mesothoracic tergum0InformativeDirect
Fly Anatomy (FA)chaeta0InformativeDirect
Fly Anatomy (FA)mechanosensory system0InformativeDirect
Fly Anatomy (FA)dorsocentral bristle0.000751Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a p53-like transcription factors domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]