SUPERFAMILY 1.75 HMM library and genome assignments server

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T-box family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   p53-like transcription factors [ 49417] (7)
Family:   T-box [ 81316] (2)


Family statistics
Genomes (149) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,006 5,179 2
Proteins 2,003 5,158 2


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)physical disorder0.00003327InformativeDirect
Disease Ontology (DO)heart disease0.0302InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1819Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.196Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.286Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3141Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.07415Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.2595Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.5567Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.6676Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiac septum morphology0.000374InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the neck0.008811InformativeInherited
Phenotypic Abnormality (PA)Abnormal palate morphology0.02335InformativeInherited
Phenotypic Abnormality (PA)Atrial septal defect0.0001725Highly InformativeDirect
Phenotypic Abnormality (PA)Cleft palate0.0004224Highly InformativeDirect
Phenotypic Abnormality (PA)Short neck0.0008531Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.001955Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.002889Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.01165Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3478Least InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.0003392Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.0007522Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system morphology0.0007701Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular development0.001415Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.02477Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.09564Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.1324Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.1678Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.4149Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.00006928InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0.00258InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.03125InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.03705InformativeInherited
Mammalian Phenotype (MP)abnormal autopod morphology0.0433InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.1641InformativeInherited
Mammalian Phenotype (MP)abnormal mouth morphology0.2731InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.2817InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.3227InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral arch morphology0.0000006432Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate morphology0.00001977Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development0.00005173Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.00007596Highly InformativeDirect
Mammalian Phenotype (MP)cleft palate0.0001474Highly InformativeDirect
Mammalian Phenotype (MP)abnormal occipital bone morphology0.0002821Highly InformativeDirect
Mammalian Phenotype (MP)abnormal atrioventricular valve morphology0.0003937Highly InformativeDirect
Mammalian Phenotype (MP)embryonic lethality during organogenesis, complete penetrance0.0005296Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart atrium morphology0.03404Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical vertebrae morphology0.07135Highly InformativeInherited
Mammalian Phenotype (MP)abnormal rib morphology0.6931Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0.3477Least InformativeInherited
Fly Anatomy (FA)embryo0.6231Least InformativeInherited
Fly Anatomy (FA)embryonic/larval circulatory system0.01099InformativeInherited
Fly Anatomy (FA)embryonic/larval dorsal vessel0.0001045Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.02469Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.03732Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.2336Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.3547Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.001544Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.01975Moderately InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.0002385InformativeDirect
Zebrafish Anatomy (ZA)pleuroperitoneal region0.02186InformativeInherited
Zebrafish Anatomy (ZA)pericardial region0.03566InformativeInherited
Zebrafish Anatomy (ZA)mesenchyme0.000004708Highly InformativeDirect
Zebrafish Anatomy (ZA)heart primordium0.0002713Highly InformativeDirect
Zebrafish Anatomy (ZA)pronephros0.0008207Highly InformativeDirect
Zebrafish Anatomy (ZA)embryonic structure0.0008207Highly InformativeDirect
Zebrafish Anatomy (ZA)heart0.001348Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.02847Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.04797Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.1486Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.3189Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.6635Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.6916Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.0001784Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.0004149Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.0004227Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.02181Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.8826Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.898Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.9826Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.000002194InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.00002329InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00002708InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.00003605InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.00005059InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0004847InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.005844InformativeInherited
Xenopus ANatomical entity (XAN)neuroectoderm0.01677InformativeInherited
Xenopus ANatomical entity (XAN)limb0.4763InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.4766InformativeInherited
Xenopus ANatomical entity (XAN)foregut0.00001478Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.0000248Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.00006625Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.0001339Highly InformativeDirect
Xenopus ANatomical entity (XAN)neurogenic placode0.0006439Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.01004Highly InformativeInherited
Xenopus ANatomical entity (XAN)blastopore lip0.7974Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.7382Least InformativeInherited
Xenopus DEvelopment stage (XDE)premetamorphosis stage0.000775Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a p53-like transcription factors domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]