SUPERFAMILY 1.75 HMM library and genome assignments server

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STAT DNA-binding domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   p53-like transcription factors [ 49417] (7)
Family:   STAT DNA-binding domain [ 81317] (3)


Family statistics
Genomes (103) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 513 1,608 3
Proteins 495 1,579 3


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.07959Least InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.00006965Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.001217Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.002007Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.0139Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.01554Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.7121Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.0000009297InformativeDirect
Disease Ontology (DO)head and neck carcinoma0.000015InformativeDirect
Disease Ontology (DO)glomerulonephritis0.00009105InformativeDirect
Disease Ontology (DO)asthma0.0001006InformativeDirect
Disease Ontology (DO)myeloid leukemia0.106InformativeInherited
Disease Ontology (DO)mumps0.000000001967Highly InformativeDirect
Disease Ontology (DO)colitis0.0000001245Highly InformativeDirect
Disease Ontology (DO)chronic leukemia0.000008105Highly InformativeDirect
Disease Ontology (DO)Sjogren's syndrome0.000009032Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.04788Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.04961Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.08194Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.0859Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2195Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.002219Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.005369Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.01078Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.01094Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.03352Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.1384Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.2234Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.3062Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Weight loss0.00009388InformativeDirect
Phenotypic Abnormality (PA)Fever0.0001033InformativeDirect
Phenotypic Abnormality (PA)Abnormal platelet count0.0001905InformativeDirect
Phenotypic Abnormality (PA)Abnormal urine cytology0.0002733InformativeDirect
Phenotypic Abnormality (PA)Fatigue0.0003357InformativeDirect
Phenotypic Abnormality (PA)Stomatitis0.0004097InformativeDirect
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.001288InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the inner ear0.05336InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymph nodes0.06492InformativeInherited
Phenotypic Abnormality (PA)Leukopenia0.00001571Highly InformativeDirect
Phenotypic Abnormality (PA)Vertigo0.0001222Highly InformativeDirect
Phenotypic Abnormality (PA)Neutropenia0.0001976Highly InformativeDirect
Phenotypic Abnormality (PA)Gangrene0.0003254Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.0007276Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.01704Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.06076Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.08954Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal T cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.000005082Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.00001074Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.0002373Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0005998Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.001262Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.01442Moderately InformativeInherited
Mammalian Phenotype (MP)adipose tissue phenotype0.01637Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.01965Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body size0.02033Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.02353Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.02684Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.03288Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.1477Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2964Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.4022Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.6902Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.8058Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interleukin level0.000000001041InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.00000009005InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland morphology0.0000002799InformativeDirect
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.000003607InformativeDirect
Mammalian Phenotype (MP)abnormal interferon-gamma secretion0.00001967InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0001615InformativeDirect
Mammalian Phenotype (MP)decreased cell proliferation0.0002318InformativeDirect
Mammalian Phenotype (MP)abnormal skin adnexa physiology0.0002751InformativeDirect
Mammalian Phenotype (MP)abnormal fat pad morphology0.0004152InformativeDirect
Mammalian Phenotype (MP)abnormal ovary morphology0.00058InformativeDirect
Mammalian Phenotype (MP)altered tumor pathology0.0006117InformativeDirect
Mammalian Phenotype (MP)abnormal antigen presentation0.0006376InformativeDirect
Mammalian Phenotype (MP)abnormal circulating triglyceride level0.000865InformativeDirect
Mammalian Phenotype (MP)abnormal innate immunity0.001375InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.006761InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.008769InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.03488InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.03891InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.1034InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.1184InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland physiology0.1352InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas physiology0.2412InformativeInherited
Mammalian Phenotype (MP)abnormal erythrocyte morphology0.5067InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interferon-gamma level0.00000006295Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.00000008816Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland epithelium physiology0.000000106Highly InformativeDirect
Mammalian Phenotype (MP)increased interferon-gamma secretion0.0000005405Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.0000007297Highly InformativeDirect
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.000002364Highly InformativeDirect
Mammalian Phenotype (MP)increased percent body fat/body weight0.000003607Highly InformativeDirect
Mammalian Phenotype (MP)enlarged liver0.000012Highly InformativeDirect
Mammalian Phenotype (MP)obese0.00001303Highly InformativeDirect
Mammalian Phenotype (MP)abnormal corpus luteum morphology0.00002358Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating leptin level0.0000284Highly InformativeDirect
Mammalian Phenotype (MP)increased lean body mass0.00004147Highly InformativeDirect
Mammalian Phenotype (MP)increased total body fat amount0.00006528Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating triglyceride level0.00007927Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mean corpuscular hemoglobin0.00008139Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating insulin level0.0002029Highly InformativeDirect
Mammalian Phenotype (MP)decreased lean body mass0.0003359Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive T cell differentiation0.0006551Highly InformativeDirect
Mammalian Phenotype (MP)impaired glucose tolerance0.0007526Highly InformativeDirect
Mammalian Phenotype (MP)abnormal food intake0.00176Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a p53-like transcription factors domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]