SUPERFAMILY 1.75 HMM library and genome assignments server

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STAT DNA-binding domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   p53-like transcription factors [ 49417] (7)
Family:   STAT DNA-binding domain [ 81317] (3)


Family statistics
Genomes (103) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 513 1,608 3
Proteins 495 1,579 3


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.07959Least InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.00006965Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.001217Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.002007Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.0139Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.01554Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.7121Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.0000009297InformativeDirect
Disease Ontology (DO)head and neck carcinoma0.000015InformativeDirect
Disease Ontology (DO)glomerulonephritis0.00009105InformativeDirect
Disease Ontology (DO)asthma0.0001006InformativeDirect
Disease Ontology (DO)myeloid leukemia0.106InformativeInherited
Disease Ontology (DO)mumps0.000000001967Highly InformativeDirect
Disease Ontology (DO)colitis0.0000001245Highly InformativeDirect
Disease Ontology (DO)chronic leukemia0.000008105Highly InformativeDirect
Disease Ontology (DO)Sjogren's syndrome0.000009032Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.0498Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.05109Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.08579Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.08626Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.225Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.001527Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.002353Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.0057Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.03468Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.03935Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.1388Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.23Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.3156Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Weight loss0.00009152InformativeDirect
Phenotypic Abnormality (PA)Fever0.0001053InformativeDirect
Phenotypic Abnormality (PA)Abnormal platelet count0.0002089InformativeDirect
Phenotypic Abnormality (PA)Abnormal urine cytology0.0002722InformativeDirect
Phenotypic Abnormality (PA)Fatigue0.0003432InformativeDirect
Phenotypic Abnormality (PA)Stomatitis0.0004162InformativeDirect
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.001292InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the inner ear0.05373InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymph nodes0.06169InformativeInherited
Phenotypic Abnormality (PA)Leukopenia0.00001613Highly InformativeDirect
Phenotypic Abnormality (PA)Vertigo0.0001227Highly InformativeDirect
Phenotypic Abnormality (PA)Neutropenia0.0002139Highly InformativeDirect
Phenotypic Abnormality (PA)Gangrene0.0003099Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.000727Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.01706Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.06074Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.08953Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal T cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.000005078Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.0000108Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.0002373Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0005994Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.001261Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.01442Moderately InformativeInherited
Mammalian Phenotype (MP)adipose tissue phenotype0.01636Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.01966Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body size0.02033Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.02351Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.02693Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.03287Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.1478Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2965Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.4014Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.6907Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.8057Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interleukin level0.00000000104InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.00000009145InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland morphology0.0000002794InformativeDirect
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.000003604InformativeDirect
Mammalian Phenotype (MP)abnormal interferon-gamma secretion0.00001965InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0001615InformativeDirect
Mammalian Phenotype (MP)decreased cell proliferation0.0002319InformativeDirect
Mammalian Phenotype (MP)abnormal skin adnexa physiology0.0002754InformativeDirect
Mammalian Phenotype (MP)abnormal fat pad morphology0.0004153InformativeDirect
Mammalian Phenotype (MP)abnormal ovary morphology0.0005799InformativeDirect
Mammalian Phenotype (MP)altered tumor pathology0.0006115InformativeDirect
Mammalian Phenotype (MP)abnormal antigen presentation0.0006366InformativeDirect
Mammalian Phenotype (MP)abnormal circulating triglyceride level0.0008651InformativeDirect
Mammalian Phenotype (MP)abnormal innate immunity0.001371InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.00676InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.008723InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.03485InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.03892InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.1035InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.1177InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland physiology0.1352InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas physiology0.2412InformativeInherited
Mammalian Phenotype (MP)abnormal erythrocyte morphology0.5067InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interferon-gamma level0.00000006289Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0000000881Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland epithelium physiology0.000000106Highly InformativeDirect
Mammalian Phenotype (MP)increased interferon-gamma secretion0.0000005396Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.0000007286Highly InformativeDirect
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.00000236Highly InformativeDirect
Mammalian Phenotype (MP)increased percent body fat/body weight0.000003604Highly InformativeDirect
Mammalian Phenotype (MP)enlarged liver0.00001199Highly InformativeDirect
Mammalian Phenotype (MP)obese0.00001301Highly InformativeDirect
Mammalian Phenotype (MP)abnormal corpus luteum morphology0.00002355Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating leptin level0.0000284Highly InformativeDirect
Mammalian Phenotype (MP)increased lean body mass0.00004142Highly InformativeDirect
Mammalian Phenotype (MP)increased total body fat amount0.00006526Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating triglyceride level0.00007927Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mean corpuscular hemoglobin0.00008137Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating insulin level0.0002029Highly InformativeDirect
Mammalian Phenotype (MP)decreased lean body mass0.0003357Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive T cell differentiation0.0006497Highly InformativeDirect
Mammalian Phenotype (MP)impaired glucose tolerance0.0007526Highly InformativeDirect
Mammalian Phenotype (MP)abnormal food intake0.001761Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a p53-like transcription factors domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]