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Rhodopsin-like family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Family A G protein-coupled receptor-like [ 81322]
Superfamily:   Family A G protein-coupled receptor-like [ 81321] (2)
Family:   Rhodopsin-like [ 81320]


Family statistics
Genomes (129) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,106 20,933 1
Proteins 2,097 20,916 1


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.6342Least InformativeInherited
Disease Ontology (DO)disease of mental health0.000003277Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.000181Moderately InformativeDirect
Disease Ontology (DO)benign neoplasm0.003818Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.02022Moderately InformativeInherited
Disease Ontology (DO)asthma0.0000008066InformativeDirect
Disease Ontology (DO)overnutrition0.000008307InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.1109InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.3741InformativeInherited
Disease Ontology (DO)migraine0.000005391Highly InformativeDirect
Disease Ontology (DO)anxiety disorder0.0002661Highly InformativeDirect
Disease Ontology (DO)endocrine organ benign neoplasm0.00477Highly InformativeInherited
Disease Ontology (DO)specific developmental disorder0.083Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.799Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.03525Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.05302Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.44Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.7583Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.9649Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.9799Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of reproductive system physiology0.01872InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.1888InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the inner ear0.4536InformativeInherited
Phenotypic Abnormality (PA)Abnormality of male external genitalia0.4883InformativeInherited
Phenotypic Abnormality (PA)Hearing impairment0.7788InformativeInherited
Phenotypic Abnormality (PA)Color vision defect0.001611Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal ovarian morphology0.01394Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the penis0.2525Highly InformativeInherited
Phenotypic Abnormality (PA)Sensorineural hearing impairment0.4137Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.003424Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.0143Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.07179Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.09409Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.419Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.668Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.9573Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype1Least InformativeInherited
Mammalian Phenotype (MP)adipose tissue phenotype0.00000104Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.000005835Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.00003725Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.04795Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.07664Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.09417Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.1139Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.2005Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body size0.2587Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.6452Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.6494Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.9246Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.954Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.9752Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.9972Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.9986Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.0000001789InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.000003649InformativeDirect
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.00005968InformativeDirect
Mammalian Phenotype (MP)abnormal consumption behavior0.00006303InformativeDirect
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.0006891InformativeDirect
Mammalian Phenotype (MP)abnormal cell migration0.002364InformativeInherited
Mammalian Phenotype (MP)abnormal sensory capabilities/reflexes/nociception0.09253InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.1746InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.24InformativeInherited
Mammalian Phenotype (MP)seizures0.4732InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.5795InformativeInherited
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.5864InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.7132InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.7388InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.8745InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.9176InformativeInherited
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.000002169Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.000008172Highly InformativeDirect
Mammalian Phenotype (MP)abnormal susceptibility to weight gain0.000009988Highly InformativeDirect
Mammalian Phenotype (MP)abnormal physiological response to xenobiotic0.00003364Highly InformativeDirect
Mammalian Phenotype (MP)abnormal catecholamine level0.00005135Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gallbladder physiology0.0002279Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body temperature homeostasis0.0003904Highly InformativeDirect
Mammalian Phenotype (MP)taste/olfaction phenotype0.0004324Highly InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to pharmacologically induced seizures0.0005729Highly InformativeDirect
Mammalian Phenotype (MP)increased white adipose tissue amount0.0006633Highly InformativeDirect
Mammalian Phenotype (MP)abnormal respiratory epithelium morphology0.004271Highly InformativeInherited
Mammalian Phenotype (MP)abnormal associative learning0.06639Highly InformativeInherited
Mammalian Phenotype (MP)abnormal olfactory bulb morphology0.3864Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.4759Highly InformativeInherited
Mammalian Phenotype (MP)abnormal diencephalon morphology0.5298Highly InformativeInherited
Mammalian Phenotype (MP)abnormal neuroendocrine gland morphology0.6713Highly InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.8651Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.1079Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.0001583Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.08152Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.58Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.58Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.5824Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.5845Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.6186Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.736Moderately InformativeInherited
Worm Phenotype (WP)egg laying variant0InformativeDirect
Worm Phenotype (WP)head movement variant0.00000000000001058InformativeDirect
Worm Phenotype (WP)body bend variant0.00000000000007508InformativeDirect
Worm Phenotype (WP)body posture variant0.00000000001324InformativeDirect
Worm Phenotype (WP)tail bend angle variant0.0000000003943InformativeDirect
Worm Phenotype (WP)foraging behavior variant0.00000005828InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.00000008419InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.0000005463InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.000007149InformativeDirect
Worm Phenotype (WP)directionality variant0.001256InformativeInherited
Worm Phenotype (WP)drug resistant0.01242InformativeInherited
Worm Phenotype (WP)drug hypersensitive0.8471InformativeInherited
Worm Phenotype (WP)locomotion reduced0.9187InformativeInherited
Worm Phenotype (WP)coiling frequency0.00000000219Highly InformativeDirect
Worm Phenotype (WP)serotonin response variant0.000000005461Highly InformativeDirect
Worm Phenotype (WP)egg laying response to drug variant0.000002246Highly InformativeDirect
Worm Phenotype (WP)fat0.00004025Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.00006285Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0.003381Highly InformativeInherited
Worm Phenotype (WP)pharyngeal pumping rate variant0.01885Highly InformativeInherited
Worm Phenotype (WP)pharyngeal pumping irregular0.375Highly InformativeInherited
Worm Phenotype (WP)frequency of body bend variant0.8328Highly InformativeInherited
Worm Phenotype (WP)egg laying defective1Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.0000004036InformativeDirect
Fly Phenotype (FP)hypoactive0.00000000124Highly InformativeDirect
Fly Phenotype (FP)courtship behavior defective0.0005489Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system1Least InformativeInherited
Xenopus ANatomical entity (XAN)head1Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.7692Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)dermal system1InformativeInherited
Xenopus ANatomical entity (XAN)eye1InformativeInherited
Xenopus ANatomical entity (XAN)surface structure1InformativeInherited
Xenopus ANatomical entity (XAN)forebrain0.2207Highly InformativeInherited
Xenopus ANatomical entity (XAN)olfactory system0.7211Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage1Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.00001536Moderately InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Family A G protein-coupled receptor-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]