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Voltage-gated potassium channels family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Voltage-gated potassium channels [ 81325]
Superfamily:   Voltage-gated potassium channels [ 81324]
Family:   Voltage-gated potassium channels [ 81323] (5)


Family statistics
Genomes (183) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 191 1,150 18
Proteins 191 1,150 18


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)heart disease0.1178InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0.00005656Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.01885Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.4095Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.9716Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.9932Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.286Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.489Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.6605Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.7983Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.8262Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.8792Moderately InformativeInherited
Phenotypic Abnormality (PA)Arrhythmia0.0005505InformativeDirect
Phenotypic Abnormality (PA)Encephalopathy0.01382InformativeInherited
Phenotypic Abnormality (PA)Abnormal blood ion concentration0.02428InformativeInherited
Phenotypic Abnormality (PA)Abnormal nervous system electrophysiology0.07027InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.6536InformativeInherited
Phenotypic Abnormality (PA)Abnormal atrioventricular conduction0.0000000549Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac test0.00000007553Highly InformativeDirect
Phenotypic Abnormality (PA)Heart block0.00000171Highly InformativeDirect
Phenotypic Abnormality (PA)Syncope0.000001747Highly InformativeDirect
Phenotypic Abnormality (PA)Hypokalemia0.000002575Highly InformativeDirect
Phenotypic Abnormality (PA)Epileptic encephalopathy0.00001881Highly InformativeDirect
Phenotypic Abnormality (PA)Metabolic alkalosis0.0001603Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperaldosteronism0.0002853Highly InformativeDirect
Phenotypic Abnormality (PA)Hypomagnesemia0.0002853Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating renin0.0002853Highly InformativeDirect
Phenotypic Abnormality (PA)Ventricular arrhythmia0.0007676Highly InformativeDirect
Phenotypic Abnormality (PA)Tachycardia0.00168Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal urine output0.006804Highly InformativeInherited
Phenotypic Abnormality (PA)Atrial arrhythmia0.4668Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.004658Least InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.003153Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.2237Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic transmission0.2926Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.6625Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system electrophysiology0.000000001687InformativeDirect
Mammalian Phenotype (MP)seizures0.0001088InformativeDirect
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.001482InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.03515InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to pharmacologically induced seizures0.00000237Highly InformativeDirect
Mammalian Phenotype (MP)abnormal distortion product otoacoustic emission0.005904Highly InformativeInherited
Mammalian Phenotype (MP)abnormal olfactory bulb morphology0.03509Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.1554Least InformativeInherited
Worm Phenotype (WP)cell development variant0.8542Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)cell morphology variant1Least InformativeInherited
Worm Phenotype (WP)cell physiology variant1Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant1Least InformativeInherited
Worm Phenotype (WP)movement variant0.001383Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.1724Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.354Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.3843Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.3925Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.4766Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.4766Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.478Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.4796Moderately InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.00003272InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.000614InformativeDirect
Worm Phenotype (WP)head movement variant0.0006291InformativeDirect
Worm Phenotype (WP)body posture variant0.0006642InformativeDirect
Worm Phenotype (WP)body bend variant0.0006913InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.005075InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.01814InformativeInherited
Worm Phenotype (WP)foraging behavior variant0.02872InformativeInherited
Worm Phenotype (WP)egg laying variant0.04245InformativeInherited
Worm Phenotype (WP)defecation variant0.04731InformativeInherited
Worm Phenotype (WP)velocity of movement variant0.05287InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.07946InformativeInherited
Worm Phenotype (WP)drug resistant0.1128InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.1464InformativeInherited
Worm Phenotype (WP)directionality variant0.2359InformativeInherited
Worm Phenotype (WP)small0.3361InformativeInherited
Worm Phenotype (WP)electrophysiology variant0.000001074Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.000001807Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.00002147Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.00005577Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0.0000593Highly InformativeDirect
Worm Phenotype (WP)forward point velocity variant0.0001475Highly InformativeDirect
Worm Phenotype (WP)dumpy0.0001522Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.0001883Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.0004162Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.0005208Highly InformativeDirect
Worm Phenotype (WP)short0.0007624Highly InformativeDirect
Worm Phenotype (WP)serotonin response variant0.0008153Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.003139Highly InformativeInherited
Worm Phenotype (WP)odorant positive chemotaxis variant0.2361Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)neurophysiology defective0.0001062InformativeDirect
Fly Phenotype (FP)behavior defective0.00774InformativeInherited
Fly Phenotype (FP)chemosensitive behavior defective0.0002022Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.1262Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.1842Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.6432Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.4078Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.4906Moderately InformativeInherited
Xenopus ANatomical entity (XAN)peripheral nervous system0.1811InformativeInherited
Xenopus ANatomical entity (XAN)eye0.7567InformativeInherited
Xenopus ANatomical entity (XAN)neuron0.00003842Highly InformativeDirect
Xenopus ANatomical entity (XAN)cell part0.002569Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve0.0111Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0001643Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Voltage-gated potassium channels domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]