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F1F0 ATP synthase subunit C superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Transmembrane helix hairpin [ 81334] (5)
Superfamily:   F1F0 ATP synthase subunit C [ 81333]
Families:   F1F0 ATP synthase subunit C [ 81332]


Superfamily statistics
Genomes (3,209) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 7,386 42,610 4
Proteins 5,690 37,043 4


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.002026Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.002936Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.00294Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.004512Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.01456Least InformativeInherited
Worm Phenotype (WP)cell development variant0.01978Least InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)level of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)organism stress response variant0.000005322Moderately InformativeDirect
Worm Phenotype (WP)germ cell differentiation variant0.0002758Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.0004046Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.0004173Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0006677Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.001534Moderately InformativeInherited
Worm Phenotype (WP)germ cell development variant0.002033Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.004324Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.007376Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.05571Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.06851Moderately InformativeInherited
Worm Phenotype (WP)oocyte physiology variant0.000001257InformativeDirect
Worm Phenotype (WP)mitosis variant0.000004825InformativeDirect
Worm Phenotype (WP)vesicle morphology variant0.000008903InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.00001033InformativeDirect
Worm Phenotype (WP)meiotic chromosome organization variant0.00001604InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.00001643InformativeDirect
Worm Phenotype (WP)cell component localization variant0.00001663InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.00001769InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.00002114InformativeDirect
Worm Phenotype (WP)nuclear appearance variant0.00005101InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.00007355InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0.00008177InformativeDirect
Worm Phenotype (WP)germ cell compartment anucleate0.0000001539Highly InformativeDirect
Worm Phenotype (WP)oocyte septum formation variant0.0000004975Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.000001342Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.000001544Highly InformativeDirect
Worm Phenotype (WP)membrane trafficking variant0.00000238Highly InformativeDirect
Worm Phenotype (WP)lysosome-related organelle morphology variant0.000004427Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.000005797Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)morphology0Moderately InformativeDirect
Yeast Phenotype (YP)nutrient utilization0Moderately InformativeDirect
Yeast Phenotype (YP)lifespan0InformativeDirect
Yeast Phenotype (YP)chemical compound accumulation0InformativeDirect
Yeast Phenotype (YP)respiratory metabolism0InformativeDirect
Yeast Phenotype (YP)vegetative growth0InformativeDirect
Yeast Phenotype (YP)subcellular morphology0InformativeDirect
Yeast Phenotype (YP)metal resistance0Highly InformativeDirect
Yeast Phenotype (YP)protein/peptide modification0Highly InformativeDirect
Yeast Phenotype (YP)alkaline pH resistance0Highly InformativeDirect
Yeast Phenotype (YP)respiratory growth0Highly InformativeDirect
Yeast Phenotype (YP)chronological lifespan0Highly InformativeDirect
Yeast Phenotype (YP)desiccation resistance0Highly InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)testis0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)limb0InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0InformativeDirect
Xenopus ANatomical entity (XAN)solid compound organ0InformativeDirect
Xenopus ANatomical entity (XAN)bone tissue0Highly InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)climax stage0Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage 660InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)L mature pollen stage0InformativeDirect
Plant structure DEvelopment stage (PDE)M germinated pollen stage0InformativeDirect

Document: AP annotation of SCOP domains

InterPro annotation
Cross references IPR002379 SSF81333 Protein matches
Abstract

The F-ATPases (or F1F0-ATPases) and V-ATPases (or V1V0-ATPases) are each composed of two linked complexes: the F1 or V1 complex contains the catalytic core that synthesizes/hydrolyses ATP, and the F0 or V0 complex that forms the membrane-spanning pore. The F- and V-ATPases all contain rotary motors, one that drives proton translocation across the membrane and one that drives ATP synthesis/hydrolysis [PubMed11309608, PubMed15629643].

This entry represents subunit C (also called subunit 9, or proteolipid in F-ATPases, or the 16 kDa proteolipid in V-ATPases) found in the F0 or V0 complex of F- and V-ATPases, respectively. In F-ATPases, ten C subunits form an oligomeric ring that makes up the F0 rotor. The flux of protons through the ATPase channel drives the rotation of the C subunit ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the C subunit ring of F0. The sequential protonation and deprotonation of Asp61 of subunit C is coupled to the stepwise movement of the rotor [PubMed14630314].

In V-ATPases, there are three proteolipid subunits (c, c and c) that form part of the proton-conducting pore, each containing a buried glutamic acid residue that is essential for proton transport, and together they form a hexameric ring spanning the membrane [PubMed15951435, PubMed14635779].

More information about this protein can be found at Protein of the Month: ATP Synthases.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a F1F0 ATP synthase subunit C domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the F1F0 ATP synthase subunit C superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]