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Aquaporin-like superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Processes_IC |
| Detailed category | Transport |
Function annotation of SCOP domain superfamilies
InterPro annotation
| Cross references | IPR000425 SSF81338 Protein matches |
| Abstract | A number of transmembrane (TM) channel proteins can be grouped together
on the basis of sequence similarities [ 8325040, 2014003, 1715617, 7529436].
These include:
- Mammalian major intrinsic protein (MIP). MIP is the major component of lens
fibre gap junctions.
- Mammalian aquaporins [7529436]. These proteins form water-
specific channels that provide the plasma membranes of red cells and kidney prox
imal and collecting tubules with high permeability to water, thereby permitting
water to move in the direction of an osmotic gradient.
- Soybean nodulin-26, a major component of the peribacteroid membrane induced
during nodulation in legume roots after Rhizobium infection.
- Plants tonoplast intrinsic proteins (TIP). There are various isoforms of TIP
: alpha (seed), gamma, Rt (root), and Wsi (water-stress induced). These proteins
may allow the diffusion of water, amino acids and/or peptides from the tonoplas
t interior to the cytoplasm..
- Bacterial glycerol facilitator protein (gene glpF), which facilitates the mo
vement of glycerol across the cytoplasmic membrane.
- Salmonella typhimurium propanediol diffusion fac
ilitator (gene pduF).
- Yeast FPS1, a glycerol uptake/efflux facilitator protein.
- Drosophila neurogenic protein 'big brain' (bib). This protein may mediate in
tercellular communication; it may functions by allowing the transport of certain
molecules(s) and thereby sending a signal for an exodermal cell to become an ep
idermoblast instead of a neuroblast.
- Yeast hypothetical protein YFL054c.
- A hypothetical protein from the pepX region of Lactococ
cus lactis.
MIP family proteins are thought to contain 6 TM domains. Sequence analysis
suggests that the proteins may have arisen through tandem, intragenic
duplication from an ancestral protein that contained 3 TM domains [].
Some of the proteins in this group are responsible for the molecular basis of
the blood group antigens, surface markers on the outside of the red blood
cell membrane. Most of these markers are proteins, but some are carbohydrates a
ttached to lipids or proteins [11845000]. Aquaporin-CHIP (Aquaporin 1) belo
ngs to the Colton blood group system and is associated with Co(a/b) antigen.
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InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 5 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a Aquaporin-like domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 5 hidden Markov models representing the Aquaporin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]
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