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Clc chloride channel superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Clc chloride channel [ 81341]
Superfamily:   Clc chloride channel [ 81340]
Families:   Clc chloride channel [ 69912]


Superfamily statistics
Genomes (2,139) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 6,141 33,059 14
Proteins 6,044 32,847 14


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1477Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.6044Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.007831Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.1209Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal blood cation concentration0.7258InformativeInherited
Phenotypic Abnormality (PA)Hypokalemia0.000007184Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1064Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6322Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.01484Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.06677Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.09376Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1657Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1855Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.1981Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.002053InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.04764InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.2817InformativeInherited
Mammalian Phenotype (MP)abnormal renal protein reabsorption0.0000001069Highly InformativeDirect
Mammalian Phenotype (MP)retinal degeneration0.00004879Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal photoreceptor morphology0.0002616Highly InformativeDirect
Mammalian Phenotype (MP)kyphosis0.0006234Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)blast cell physiology variant0.0007419Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0007434Least InformativeDirect
Worm Phenotype (WP)electrophysiology variant0InformativeDirect
Worm Phenotype (WP)neuron physiology variant0.0000000000003634Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

InterPro annotation
Cross references IPR014743 SSF81340 Protein matches
Abstract

This entry represents the core domain of the cholide ion channel.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Clc chloride channel domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Clc chloride channel superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]