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PAP/OAS1 substrate-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   PAP/OAS1 substrate-binding domain [ 81632]
Superfamily:   PAP/OAS1 substrate-binding domain [ 81631] (5)
Families:   Poly(A) polymerase, PAP, middle domain [ 81630]
  2'-5'-oligoadenylate synthetase 1, OAS1, second domain [ 101271]
  Archaeal tRNA CCA-adding enzyme substrate-binding domain [ 101274]
  RNA editing terminal uridyl transferase 2, RET2, domain 2 [ 140679]
  AadK C-terminal domain-like [ 158607]


Superfamily statistics
Genomes (902) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 5,944 15,382 11
Proteins 5,647 14,653 11


Functional annotation
General category Information
Detailed category RNA processing

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.003569 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 0.03519 Least Informative Inherited
Biological Process (BP) response to stimulus 0.2496 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.6155 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) immune system process 0.00001409 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.00000000000133 Moderately Informative Direct
Biological Process (BP) defense response 0.00000001212 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000000002609 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0 Moderately Informative Direct
Biological Process (BP) gene expression 0.0000000006185 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.0000000008283 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.0000002835 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 0.00000000000004085 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.2969 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.1969 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.004923 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 0.04749 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.8215 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.002098 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.04796 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1323 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.01252 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.01046 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.8904 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.5114 Moderately Informative Inherited
Biological Process (BP) immune effector process 0.00000000117 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0 Informative Direct
Biological Process (BP) negative regulation of gene expression 0.0000001668 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.00000002142 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000000001008 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.000002239 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0 Informative Direct
Biological Process (BP) cell cycle process 0.09899 Informative Inherited
Biological Process (BP) defense response to other organism 0.02691 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.005927 Informative Inherited
Biological Process (BP) ncRNA processing 0.8996 Informative Inherited
Biological Process (BP) nuclear division 0.0006024 Highly Informative Direct
Biological Process (BP) RNA catabolic process 0.000000000005867 Highly Informative Direct
Biological Process (BP) response to virus 0 Highly Informative Direct
Biological Process (BP) gene silencing 0.00001722 Highly Informative Direct
Biological Process (BP) negative regulation of multi-organism process 0 Highly Informative Direct
Biological Process (BP) regulation of viral process 0 Highly Informative Direct
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.0006691 Highly Informative Direct
Biological Process (BP) nuclear chromosome segregation 0.0004175 Highly Informative Direct
Biological Process (BP) mRNA processing 0.001853 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 1 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.002053 Highly Informative Inherited
Molecular Function (MF) binding 0.0000005116 Least Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0.00025 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.0000006648 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0001822 Moderately Informative Direct
Molecular Function (MF) anion binding 0.2578 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.004063 Moderately Informative Inherited
Molecular Function (MF) RNA binding 0 Informative Direct
Molecular Function (MF) nucleotidyltransferase activity 0 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.000000002422 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0000003431 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.007531 Informative Inherited
Molecular Function (MF) ATP binding 0.000000000015 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00005516 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.5445 Least Informative Inherited
Cellular Component (CC) protein complex 0.09777 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.3119 Least Informative Inherited
Cellular Component (CC) nuclear part 0.000003371 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0001789 Moderately Informative Direct
Cellular Component (CC) nucleoplasm part 0.2074 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)CCA tRNA nucleotidyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0Moderately InformativeDirect
Biological processCell cycle0.1522Moderately InformativeInherited
Biological processInnate immunity0InformativeDirect
Biological processmRNA processing0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processMitosis0.000013InformativeDirect
Biological processAntiviral defense0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentEndoplasmic reticulum0.000003078Moderately InformativeDirect
Cellular componentMitochondrion0.0005826Moderately InformativeDirect
Cellular componentMicrosome0.0000009797Highly InformativeDirect
DomainZinc-finger0.0004648Moderately InformativeDirect
Molecular functionMagnesium0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationRNA-binding0Moderately InformativeDirect
Post-translational modificationAcetylation0.0001985Least InformativeDirect
Post-translational modificationPhosphoprotein0.0002803Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PAP/OAS1 substrate-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the PAP/OAS1 substrate-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]