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Cytoplasmic domain of inward rectifier potassium channel family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   E set domains [ 81296] (23)
Family:   Cytoplasmic domain of inward rectifier potassium channel [ 81966] (3)


Family statistics
Genomes (243) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,429 4,135 3
Proteins 1,428 4,102 3


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)syndrome0.0007126Moderately InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.172Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1943Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.353Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.01075Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.01982Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.0304Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.05127Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.07818Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.1509Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.2624Moderately InformativeInherited
Phenotypic Abnormality (PA)Arrhythmia0.000364InformativeDirect
Phenotypic Abnormality (PA)Abnormal blood ion concentration0.006728InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.05017InformativeInherited
Phenotypic Abnormality (PA)Tachycardia0.0000002194Highly InformativeDirect
Phenotypic Abnormality (PA)Hypokalemia0.0000003584Highly InformativeDirect
Phenotypic Abnormality (PA)Metabolic alkalosis0.0000004621Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperaldosteronism0.0000008772Highly InformativeDirect
Phenotypic Abnormality (PA)Hypomagnesemia0.0000008772Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating renin0.0000008772Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal atrioventricular conduction0.000001477Highly InformativeDirect
Phenotypic Abnormality (PA)Heart block0.00001053Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac test0.00001235Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal urine output0.00003753Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal urinary electrolyte concentration0.0008897Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.3943Least InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)seizures0.007855InformativeInherited
Mammalian Phenotype (MP)tonic-clonic seizures0.00006152Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Least InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)anatomical cluster0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 164 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a E set domains domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]