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Cytoplasmic domain of inward rectifier potassium channel family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   E set domains [ 81296] (23)
Family:   Cytoplasmic domain of inward rectifier potassium channel [ 81966] (3)


Family statistics
Genomes (243) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,429 4,135 3
Proteins 1,428 4,102 3


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)syndrome0.0007126Moderately InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1719Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.1762Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1997Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.006405Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.0114Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.02033Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.05376Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.1381Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.1525Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.2643Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal blood cation concentration0.00002692InformativeDirect
Phenotypic Abnormality (PA)Arrhythmia0.0003729InformativeDirect
Phenotypic Abnormality (PA)Abnormal renal physiology0.0515InformativeInherited
Phenotypic Abnormality (PA)Hypokalemia0.00000000382Highly InformativeDirect
Phenotypic Abnormality (PA)Tachycardia0.0000002063Highly InformativeDirect
Phenotypic Abnormality (PA)Metabolic alkalosis0.0000004454Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperaldosteronism0.0000008489Highly InformativeDirect
Phenotypic Abnormality (PA)Hypomagnesemia0.0000008489Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating renin0.0000008489Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal atrioventricular conduction0.000001948Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cardiac test0.00001229Highly InformativeDirect
Phenotypic Abnormality (PA)Heart block0.00001244Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal urine output0.0000539Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal urinary electrolyte concentration0.000899Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.3941Least InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)seizures0.007846InformativeInherited
Mammalian Phenotype (MP)tonic-clonic seizures0.00006147Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)progeny variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)anatomical cluster0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 164 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a E set domains domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]